iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020330

Ensembl Protein ID

ENSCAFP00000007113.3

UniProt Accession

E2RBP8; E2RBP8_CANLF

Genbank Protein ID

ENSCAFP00000007113

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03001269

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000004769.3	ENSCAFT00000007679.3	ENSCAFP00000007113.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	9.20e-25	86.7	456	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k++++++d++
   Q: 456  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNAFEDGG 512
           79****************************************************986 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MIPVGPTAMS HQPLSCLTAK GDSSNETTGN GPPNLAHPNL DTFTPEELLQ QMKELLTENH 60
QLKEAMKLNN QAMKGRFEEL SAWTEKQKEE RLYFEVQSKE AKERLMALSH ENEKLKEELE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATACCAG TGGGTAAGTG GGGGCCAGAC TCTGAAAGGC CATGTTTTTC TCATTTGGGA 60
GCTGGAACTC TGTCCTGTAT GGGAAGGGTT TTAAGCAGGA GAGTGACTTC CTGCTGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	89.53	0.00e+00	876.00
IUUC-Apl-003812	Anas platyrhynchos	56.43	1.00e-144	506.00
IUUC-Aca-004625	Anolis carolinensis	54.37	4.00e-140	491.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.10e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	47.40	2.00e-56	213.00
IUUC-Bta-013240	Bos taurus	85.89	0.00e+00	909.00
IUUC-Cel-018324	Caenorhabditis elegans	45.83	1.50e+00	27.30
IUUC-Cja-019911	Callithrix jacchus	83.62	0.00e+00	836.00
IUUC-Cpo-021753	Cavia porcellus	81.42	0.00e+00	831.00
IUUC-Csa-023662	Chlorocebus sabaeus	85.52	0.00e+00	857.00
IUUC-Cho-024574	Choloepus hoffmanni	66.92	5.00e-125	441.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.80	1.30e-01	31.20
IUUC-Dre-027720	Danio rerio	40.46	2.00e-91	329.00
IUUC-Dno-029079	Dasypus novemcinctus	81.53	0.00e+00	781.00
IUUC-Dor-030890	Dipodomys ordii	79.62	0.00e+00	821.00
IUUC-Ete-032568	Echinops telfairi	78.71	0.00e+00	697.00
IUUC-Eca-033528	Equus caballus	86.84	0.00e+00	893.00
IUUC-Eeu-035219	Erinaceus europaeus	75.39	0.00e+00	775.00
IUUC-Fca-035852	Felis catus	89.25	0.00e+00	908.00
IUUC-Fal-036862	Ficedula albicollis	57.22	1.00e-140	493.00
IUUC-Gmo-038735	Gadus morhua	38.99	8.00e-75	274.00
IUUC-Gga-040939	Gallus gallus	55.13	2.00e-143	502.00
IUUC-Gac-041580	Gasterosteus aculeatus	43.01	2.00e-93	336.00
IUUC-Ggo-045034	Gorilla gorilla	76.48	0.00e+00	761.00
IUUC-Hsa-046624	Homo sapiens	84.14	0.00e+00	843.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	75.09	0.00e+00	782.00
IUUC-Lch-049720	Latimeria chalumnae	49.51	1.00e-78	286.00
IUUC-Loc-052185	Lepisosteus oculatus	45.13	7.00e-101	361.00
IUUC-Laf-054079	Loxodonta africana	82.48	0.00e+00	830.00
IUUC-Mcc-055674	Macaca mulatta	86.53	0.00e+00	863.00
IUUC-Meu-056769	Macropus eugenii	82.84	3.00e-71	263.00
IUUC-Mga-060203	Meleagris gallopavo	54.94	4.00e-133	468.00
IUUC-Mmr-061492	Microcebus murinus	84.15	0.00e+00	830.00
IUUC-Mdo-063051	Monodelphis domestica	74.87	0.00e+00	769.00
IUUC-Mmu-063409	Mus musculus	77.78	0.00e+00	837.00
IUUC-Mpu-065907	Mustela putorius furo	85.20	0.00e+00	902.00
IUUC-Mlu-066957	Myotis lucifugus	84.15	0.00e+00	807.00
IUUC-Nle-069973	Nomascus leucogenys	84.83	0.00e+00	850.00
IUUC-Opr-071049	Ochotona princeps	77.89	0.00e+00	725.00
IUUC-Ont-071915	Oreochromis niloticus	44.01	9.00e-91	327.00
IUUC-Oan-072965	Ornithorhynchus anatinus	71.92	0.00e+00	744.00
IUUC-Ocu-074029	Oryctolagus cuniculus	75.42	0.00e+00	664.00
IUUC-Ola-087019	Oryzias latipes	41.78	5.00e-85	308.00
IUUC-Oga-088613	Otolemur garnettii	84.17	0.00e+00	849.00
IUUC-Oar-090386	Ovis aries	85.89	0.00e+00	906.00
IUUC-Ptr-091619	Pan troglodytes	83.97	0.00e+00	840.00
IUUC-Pan-092178	Papio anubis	84.91	0.00e+00	846.00
IUUC-Psi-093214	Pelodiscus sinensis	61.34	9.00e-156	543.00
IUUC-Pfo-096901	Poecilia formosa	40.60	9.00e-85	307.00
IUUC-Pab-097560	Pongo abelii	77.07	0.00e+00	729.00
IUUC-Pca-100853	Procavia capensis	70.78	3.00e-115	409.00
IUUC-Pva-102255	Pteropus vampyrus	85.59	0.00e+00	807.00
IUUC-Rno-105812	Rattus norvegicus	79.86	0.00e+00	842.00
IUUC-Sha-107225	Sarcophilus harrisii	79.89	2.00e-150	525.00
IUUC-Sar-113736	Sorex araneus	69.72	3.00e-125	442.00
IUUC-Ssc-115422	Sus scrofa	86.59	0.00e+00	906.00
IUUC-Tgu-116924	Taeniopygia guttata	57.27	1.00e-143	503.00
IUUC-Tru-117695	Takifugu rubripes	39.66	3.00e-85	309.00
IUUC-Tsy-119090	Tarsius syrichta	79.27	1.00e-139	489.00
IUUC-Tni-120645	Tetraodon nigroviridis	42.15	1.00e-86	313.00
IUUC-Tbe-127970	Tupaia belangeri	70.38	4.00e-138	484.00
IUUC-Ttr-129244	Tursiops truncatus	85.59	0.00e+00	845.00
IUUC-Vpa-130313	Vicugna pacos	84.20	0.00e+00	798.00
IUUC-Xtr-132115	Xenopus tropicalis	45.11	5.00e-91	328.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence