iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-047945

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01009982

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000013110.2	ENSSTOT00000013112.2	ENSSTOP00000011753.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-135	452.1	202	534

Active Site

Position(s)	Description	Evidence
503	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 202  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 289
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 290  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELFFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 375
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 376  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDLSDWQKNTVYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 463
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 464  TGTCRLPVGGFVELIgingPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 534
           *********************************************************************96 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

WEKRTDPRGR FYYVDHNTRT TTWQRPTAEY VRNYEQWQSQ RNQLQGAMQH FSQRFLYQSS 60
NPSVDHDPLG PLPPGWEKRQ DNGRVYYVNH NTRTTQWEDP RTQGMIQEPA LPPGWEMKYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGAAAAAC GCACAGACCC CCGAGGGCGG TTTTACTATG TGGACCACAA CACTCGGACC 60
ACCACCTGGC AGCGACCGAC AGCTGAGTAT GTGCGGAACT ACGAACAGTG GCAGTCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	97.77	0.00e+00	1113.00
IUUC-Apl-003912	Anas platyrhynchos	90.61	0.00e+00	1027.00
IUUC-Aca-004291	Anolis carolinensis	96.27	0.00e+00	1095.00
IUUC-Bta-013231	Bos taurus	98.13	0.00e+00	1115.00
IUUC-Cja-019455	Callithrix jacchus	98.32	0.00e+00	1122.00
IUUC-Cfa-021017	Canis familiaris	98.32	0.00e+00	1118.00
IUUC-Cpo-021988	Cavia porcellus	98.32	0.00e+00	1121.00
IUUC-Csa-023549	Chlorocebus sabaeus	97.57	0.00e+00	1115.00
IUUC-Dre-028513	Danio rerio	91.42	0.00e+00	1045.00
IUUC-Dno-028976	Dasypus novemcinctus	98.50	0.00e+00	1123.00
IUUC-Dor-030176	Dipodomys ordii	98.32	0.00e+00	1110.00
IUUC-Eca-033949	Equus caballus	97.76	0.00e+00	1116.00
IUUC-Eeu-034529	Erinaceus europaeus	97.76	0.00e+00	931.00
IUUC-Fca-036236	Felis catus	98.32	0.00e+00	1120.00
IUUC-Fal-036948	Ficedula albicollis	95.52	0.00e+00	1077.00
IUUC-Gmo-038842	Gadus morhua	88.83	0.00e+00	990.00
IUUC-Gga-040617	Gallus gallus	95.52	0.00e+00	1085.00
IUUC-Ggo-045278	Gorilla gorilla	98.13	0.00e+00	1117.00
IUUC-Hsa-046148	Homo sapiens	98.13	0.00e+00	1118.00
IUUC-Lch-050663	Latimeria chalumnae	93.66	0.00e+00	1067.00
IUUC-Laf-053944	Loxodonta africana	97.76	0.00e+00	1117.00
IUUC-Mcc-055655	Macaca mulatta	97.57	0.00e+00	1115.00
IUUC-Meu-055953	Macropus eugenii	83.40	0.00e+00	925.00
IUUC-Mga-060190	Meleagris gallopavo	95.34	0.00e+00	1085.00
IUUC-Mmr-060896	Microcebus murinus	98.32	0.00e+00	1120.00
IUUC-Mdo-062536	Monodelphis domestica	96.83	0.00e+00	1103.00
IUUC-Mmu-064017	Mus musculus	97.94	0.00e+00	1117.00
IUUC-Mpu-066608	Mustela putorius furo	94.96	0.00e+00	1075.00
IUUC-Mlu-067623	Myotis lucifugus	94.40	0.00e+00	1067.00
IUUC-Nle-069496	Nomascus leucogenys	95.14	0.00e+00	1076.00
IUUC-Opr-071054	Ochotona princeps	97.38	0.00e+00	1100.00
IUUC-Ont-071279	Oreochromis niloticus	90.86	0.00e+00	1003.00
IUUC-Oan-073512	Ornithorhynchus anatinus	96.46	0.00e+00	1097.00
IUUC-Ocu-074271	Oryctolagus cuniculus	97.57	0.00e+00	1112.00
IUUC-Ola-087237	Oryzias latipes	88.08	0.00e+00	957.00
IUUC-Oga-088164	Otolemur garnettii	98.32	0.00e+00	1118.00
IUUC-Oar-089698	Ovis aries	98.13	0.00e+00	1114.00
IUUC-Ptr-091306	Pan troglodytes	95.89	0.00e+00	1086.00
IUUC-Pan-092814	Papio anubis	96.07	0.00e+00	1091.00
IUUC-Pfo-096709	Poecilia formosa	90.30	0.00e+00	998.00
IUUC-Pab-098494	Pongo abelii	97.94	0.00e+00	1115.00
IUUC-Pca-100596	Procavia capensis	97.48	0.00e+00	983.00
IUUC-Pva-103154	Pteropus vampyrus	97.63	0.00e+00	1051.00
IUUC-Rno-104954	Rattus norvegicus	97.20	0.00e+00	1106.00
IUUC-Sha-106781	Sarcophilus harrisii	96.64	0.00e+00	1100.00
IUUC-Ssc-116307	Sus scrofa	92.18	0.00e+00	1038.00
IUUC-Tgu-116530	Taeniopygia guttata	89.35	0.00e+00	990.00
IUUC-Tbe-127793	Tupaia belangeri	87.22	0.00e+00	952.00
IUUC-Ttr-128275	Tursiops truncatus	97.57	0.00e+00	1111.00
IUUC-Xtr-132866	Xenopus tropicalis	90.69	0.00e+00	1038.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence