iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053944

UUCD1 version

UUC-LoA-00457

Ensembl Protein ID

ENSLAFP00000011190.4

UniProt Accession

G3TB66; G3TB66_LOXAF

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000013368.4	ENSLAFT00000013372.4	ENSLAFP00000011190.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-135	452.2	537	869

Active Site

Position(s)	Description	Evidence
838	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIIWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s+++qwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQMQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f++ k +++++lP+s+TCfn+L+LP+Y+s+e+l+ekLlyAieet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCVDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQ 869
           *********************************************************************96 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLFNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCTG CCAGCTCCAG CCGGGCAGGA GTGGCCCTGC CTTTTGAGAA GTCTCAGCTT 60
ACTTTGAAAG GTGAGTGGTA CCATGTGCAG TGTTTATCAT TTGAAGTCTC AGCCTAATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

KEGG

lav:100662968

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	96.22	0.00e+00	1645.00
IUUC-Apl-003912	Anas platyrhynchos	76.27	0.00e+00	1230.00
IUUC-Aca-004291	Anolis carolinensis	80.67	0.00e+00	1428.00
IUUC-Bta-013231	Bos taurus	94.94	0.00e+00	1599.00
IUUC-Cja-019455	Callithrix jacchus	95.63	0.00e+00	1683.00
IUUC-Cfa-021017	Canis familiaris	97.13	0.00e+00	1640.00
IUUC-Cpo-021988	Cavia porcellus	94.94	0.00e+00	1656.00
IUUC-Csa-023549	Chlorocebus sabaeus	95.86	0.00e+00	1692.00
IUUC-Dre-028513	Danio rerio	91.94	0.00e+00	1137.00
IUUC-Dno-028976	Dasypus novemcinctus	96.90	0.00e+00	1700.00
IUUC-Dor-030176	Dipodomys ordii	92.32	0.00e+00	1507.00
IUUC-Eca-033949	Equus caballus	96.78	0.00e+00	1660.00
IUUC-Eeu-034529	Erinaceus europaeus	88.86	0.00e+00	1387.00
IUUC-Fca-036236	Felis catus	97.01	0.00e+00	1697.00
IUUC-Fal-036948	Ficedula albicollis	78.44	0.00e+00	1331.00
IUUC-Gmo-038842	Gadus morhua	89.24	0.00e+00	1070.00
IUUC-Gga-040617	Gallus gallus	80.20	0.00e+00	1434.00
IUUC-Gac-041338	Gasterosteus aculeatus	70.26	0.00e+00	1253.00
IUUC-Ggo-045278	Gorilla gorilla	96.09	0.00e+00	1694.00
IUUC-Hsa-046148	Homo sapiens	96.09	0.00e+00	1694.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	97.76	0.00e+00	1118.00
IUUC-Lch-050663	Latimeria chalumnae	78.62	0.00e+00	1390.00
IUUC-Loc-052604	Lepisosteus oculatus	76.17	0.00e+00	1318.00
IUUC-Mcc-055655	Macaca mulatta	95.75	0.00e+00	1692.00
IUUC-Meu-055953	Macropus eugenii	80.28	0.00e+00	1384.00
IUUC-Mga-060190	Meleagris gallopavo	80.70	0.00e+00	1436.00
IUUC-Mmr-060896	Microcebus murinus	95.95	0.00e+00	1638.00
IUUC-Mdo-062536	Monodelphis domestica	91.63	0.00e+00	1614.00
IUUC-Mmu-064017	Mus musculus	94.83	0.00e+00	1648.00
IUUC-Mpu-066608	Mustela putorius furo	93.92	0.00e+00	1590.00
IUUC-Mlu-067623	Myotis lucifugus	92.88	0.00e+00	1603.00
IUUC-Nle-069496	Nomascus leucogenys	93.92	0.00e+00	1643.00
IUUC-Opr-071054	Ochotona princeps	84.10	0.00e+00	1425.00
IUUC-Oan-073512	Ornithorhynchus anatinus	88.30	0.00e+00	1489.00
IUUC-Ocu-074271	Oryctolagus cuniculus	94.98	0.00e+00	1624.00
IUUC-Ola-087237	Oryzias latipes	70.08	0.00e+00	1231.00
IUUC-Oga-088164	Otolemur garnettii	96.55	0.00e+00	1692.00
IUUC-Oar-089698	Ovis aries	95.29	0.00e+00	1611.00
IUUC-Ptr-091306	Pan troglodytes	94.83	0.00e+00	1664.00
IUUC-Pan-092814	Papio anubis	91.97	0.00e+00	1600.00
IUUC-Pfo-096709	Poecilia formosa	72.86	0.00e+00	1284.00
IUUC-Pab-098494	Pongo abelii	90.39	0.00e+00	1596.00
IUUC-Pca-100596	Procavia capensis	85.46	0.00e+00	1401.00
IUUC-Pva-103154	Pteropus vampyrus	90.96	0.00e+00	1567.00
IUUC-Rno-104954	Rattus norvegicus	94.98	0.00e+00	1419.00
IUUC-Sha-106781	Sarcophilus harrisii	91.28	0.00e+00	1649.00
IUUC-Ssc-116307	Sus scrofa	84.85	0.00e+00	1454.00
IUUC-Tgu-116530	Taeniopygia guttata	76.23	0.00e+00	1190.00
IUUC-Tru-118287	Takifugu rubripes	89.63	0.00e+00	1068.00
IUUC-Tsy-119097	Tarsius syrichta	82.71	0.00e+00	1223.00
IUUC-Tni-120801	Tetraodon nigroviridis	76.54	0.00e+00	1083.00
IUUC-Tbe-127793	Tupaia belangeri	83.79	0.00e+00	1436.00
IUUC-Ttr-128275	Tursiops truncatus	91.15	0.00e+00	1552.00
IUUC-Xtr-132866	Xenopus tropicalis	82.18	0.00e+00	1128.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence