iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074271

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAGW02055489

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000010764.3	ENSOCUT00000010764.3	ENSOCUP00000009267.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-135	450.2	535	867

Active Site

Position(s)	Description	Evidence
836	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 535  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 622
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk gGe+i+Vt+eNkeeY+ l+++
   Q: 623  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKAGGESIRVTEENKEEYIMLLTD 708
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ y ++s+++qwFw+v++e+++e+r ++LqFv
   Q: 709  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDLSDWQKNTVYRH-YAKSSKQVQWFWQVVKEMDNEKRIRLLQFV 796
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 797  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 867
           *********************************************************************96 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MASASASRAA AAPPFEKSQL TLKVVSAKPK VHHRQPRINS YVEVAVDGLP GETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSSVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCACGTGA CCCGGCCCGA GTGCGGGCGG TGGAAGGCGG AAGTGGGAGA GGAGTTGGGC 60
GCCGCTTCTG GGGCCGGGGC AGGTAGCGAG CGCGGGCGCG NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

KEGG

ocu:100344222

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	93.71	0.00e+00	1595.00
IUUC-Apl-003912	Anas platyrhynchos	76.27	0.00e+00	1222.00
IUUC-Aca-004291	Anolis carolinensis	81.30	0.00e+00	1427.00
IUUC-Bta-013231	Bos taurus	91.95	0.00e+00	1570.00
IUUC-Cel-018299	Caenorhabditis elegans	67.53	0.00e+00	832.00
IUUC-Cja-019455	Callithrix jacchus	93.82	0.00e+00	1640.00
IUUC-Cfa-021017	Canis familiaris	93.47	0.00e+00	1590.00
IUUC-Cpo-021988	Cavia porcellus	95.22	0.00e+00	1627.00
IUUC-Csa-023549	Chlorocebus sabaeus	93.93	0.00e+00	1652.00
IUUC-Cin-025212	Ciona intestinalis	71.80	0.00e+00	869.00
IUUC-Csv-026256	Ciona savignyi	70.76	0.00e+00	860.00
IUUC-Dre-028513	Danio rerio	91.42	0.00e+00	1131.00
IUUC-Dno-028976	Dasypus novemcinctus	93.82	0.00e+00	1635.00
IUUC-Dor-030176	Dipodomys ordii	93.72	0.00e+00	1509.00
IUUC-Dme-032041	Drosophila melanogaster	69.15	0.00e+00	859.00
IUUC-Eca-033949	Equus caballus	94.28	0.00e+00	1610.00
IUUC-Eeu-034529	Erinaceus europaeus	87.63	0.00e+00	1338.00
IUUC-Fca-036236	Felis catus	94.98	0.00e+00	1643.00
IUUC-Fal-036948	Ficedula albicollis	77.22	0.00e+00	1325.00
IUUC-Gmo-038842	Gadus morhua	88.36	0.00e+00	1061.00
IUUC-Gga-040617	Gallus gallus	79.71	0.00e+00	1423.00
IUUC-Gac-041338	Gasterosteus aculeatus	69.28	0.00e+00	1229.00
IUUC-Ggo-045278	Gorilla gorilla	94.40	0.00e+00	1656.00
IUUC-Hsa-046148	Homo sapiens	94.40	0.00e+00	1656.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	97.57	0.00e+00	1114.00
IUUC-Lch-050663	Latimeria chalumnae	78.53	0.00e+00	1371.00
IUUC-Loc-052604	Lepisosteus oculatus	75.54	0.00e+00	1307.00
IUUC-Laf-053944	Loxodonta africana	94.98	0.00e+00	1625.00
IUUC-Mcc-055655	Macaca mulatta	94.05	0.00e+00	1654.00
IUUC-Meu-055953	Macropus eugenii	79.74	0.00e+00	1353.00
IUUC-Mga-060190	Meleagris gallopavo	79.71	0.00e+00	1425.00
IUUC-Mmr-060896	Microcebus murinus	94.63	0.00e+00	1610.00
IUUC-Mdo-062536	Monodelphis domestica	90.34	0.00e+00	1572.00
IUUC-Mmu-064017	Mus musculus	93.82	0.00e+00	1615.00
IUUC-Mpu-066608	Mustela putorius furo	90.57	0.00e+00	1550.00
IUUC-Mlu-067623	Myotis lucifugus	92.19	0.00e+00	1554.00
IUUC-Nle-069496	Nomascus leucogenys	92.31	0.00e+00	1607.00
IUUC-Opr-071054	Ochotona princeps	86.20	0.00e+00	1457.00
IUUC-Ont-071279	Oreochromis niloticus	72.26	0.00e+00	1256.00
IUUC-Oan-073512	Ornithorhynchus anatinus	87.12	0.00e+00	1471.00
IUUC-Ola-087237	Oryzias latipes	69.47	0.00e+00	1204.00
IUUC-Oga-088164	Otolemur garnettii	95.10	0.00e+00	1655.00
IUUC-Oar-089698	Ovis aries	92.07	0.00e+00	1578.00
IUUC-Ptr-091306	Pan troglodytes	93.12	0.00e+00	1625.00
IUUC-Pan-092814	Papio anubis	90.10	0.00e+00	1556.00
IUUC-Pma-094279	Petromyzon marinus	70.91	0.00e+00	802.00
IUUC-Pfo-096709	Poecilia formosa	73.64	0.00e+00	1263.00
IUUC-Pab-098494	Pongo abelii	90.35	0.00e+00	1573.00
IUUC-Pca-100596	Procavia capensis	83.22	0.00e+00	1362.00
IUUC-Pva-103154	Pteropus vampyrus	90.34	0.00e+00	1523.00
IUUC-Rno-104954	Rattus norvegicus	93.39	0.00e+00	1409.00
IUUC-Sha-106781	Sarcophilus harrisii	90.92	0.00e+00	1621.00
IUUC-Ssc-116307	Sus scrofa	83.74	0.00e+00	1424.00
IUUC-Tgu-116530	Taeniopygia guttata	75.59	0.00e+00	1179.00
IUUC-Tru-118287	Takifugu rubripes	88.93	0.00e+00	1060.00
IUUC-Tsy-119097	Tarsius syrichta	82.53	0.00e+00	1199.00
IUUC-Tni-120801	Tetraodon nigroviridis	68.13	0.00e+00	1129.00
IUUC-Tbe-127793	Tupaia belangeri	82.38	0.00e+00	1409.00
IUUC-Ttr-128275	Tursiops truncatus	88.33	0.00e+00	1518.00
IUUC-Uma-129332	Ustilago maydis	46.36	1.00e-142	500.00
IUUC-Xtr-132866	Xenopus tropicalis	82.15	0.00e+00	1120.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence