iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000016276.3	ENSMMUT00000070597.1	ENSMMUP00000051532.1
ENSMMUG00000016276.3	ENSMMUT00000022863.3	ENSMMUP00000021384.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.70e-06	28.9	14	57
E3 activity/RING/U-box	1.00e-05	26.6	10	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ f+  p++  CgH f++ Cl ++      + ++ +CP C+
   Q: 14   CPLCLQLFDA-PVTAECGHSFCRACLGRV-AGEPAADGTVLCPCCQ 57
           ********99.999***************.5555799999*****7 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl...asggk....tcPvtrqplteedlvPnltlrrliq 66
           +e+ Cp+ l+l+  Pv++++G+++ r+++ +     a         cP +++p++++ l  nl l rl++
   Q: 10   QELSCPLCLQLFDAPVTAECGHSFCRACLGRVAgepA---AdgtvLCPCCQAPTRPQALSTNLQLARLVE 76
           7899***************************765553...144479****************99988765 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT 60
RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACAGTGGA TGGGCCAAGA CAGGTGGCCC TGGCATGTGA TGCGTGCACG GGGACTACTC 60
AGCTCTCACT TTTAGAACGG TTTCCGGAAG TGATGGGAGG GATTGGGCAG GGCAGCTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0042383--C:sarcolemma
GO:0001786--F:phosphatidylserine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007517--P:muscle organ development
GO:0003012--P:muscle system process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0043569--P:negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010832--P:negative regulation of myotube differentiation
GO:0001778--P:plasma membrane repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002377	Ailuropoda melanoleuca	74.59	0.00e+00	640.00
IUUC-Aca-004755	Anolis carolinensis	63.03	2.00e-169	588.00
IUUC-Bta-013476	Bos taurus	76.78	0.00e+00	716.00
IUUC-Cja-018969	Callithrix jacchus	84.98	0.00e+00	748.00
IUUC-Cfa-020155	Canis familiaris	91.65	0.00e+00	848.00
IUUC-Cpo-021646	Cavia porcellus	87.89	0.00e+00	816.00
IUUC-Cre-022560	Chlamydomonas reinhardtii	44.90	1.00e-05	45.40
IUUC-Csa-023855	Chlorocebus sabaeus	97.34	1.00e-180	625.00
IUUC-Dno-029142	Dasypus novemcinctus	90.40	0.00e+00	766.00
IUUC-Dor-030394	Dipodomys ordii	68.80	4.00e-88	318.00
IUUC-Ete-032801	Echinops telfairi	83.85	7.00e-64	237.00
IUUC-Eca-034378	Equus caballus	92.69	0.00e+00	842.00
IUUC-Eeu-034526	Erinaceus europaeus	83.93	0.00e+00	731.00
IUUC-Fca-036440	Felis catus	92.07	0.00e+00	864.00
IUUC-Ggo-045086	Gorilla gorilla	97.69	0.00e+00	695.00
IUUC-Hsa-046533	Homo sapiens	97.49	0.00e+00	872.00
IUUC-Itr-048959	Ictidomys tridecemlineatus	91.65	0.00e+00	855.00
IUUC-Laf-054479	Loxodonta africana	91.65	0.00e+00	850.00
IUUC-Meu-056767	Macropus eugenii	73.73	0.00e+00	684.00
IUUC-Mmr-061616	Microcebus murinus	92.90	0.00e+00	862.00
IUUC-Mdo-062252	Monodelphis domestica	76.09	0.00e+00	714.00
IUUC-Mmu-063094	Mus musculus	89.77	0.00e+00	821.00
IUUC-Mpu-065885	Mustela putorius furo	77.04	0.00e+00	655.00
IUUC-Mlu-068150	Myotis lucifugus	64.36	1.00e-85	309.00
IUUC-Nle-069476	Nomascus leucogenys	97.71	0.00e+00	871.00
IUUC-Opr-070871	Ochotona princeps	90.65	7.00e-139	487.00
IUUC-Oan-072738	Ornithorhynchus anatinus	75.52	0.00e+00	702.00
IUUC-Ocu-074132	Oryctolagus cuniculus	93.42	0.00e+00	645.00
IUUC-Oga-088268	Otolemur garnettii	63.75	1.00e-144	506.00
IUUC-Oar-089555	Ovis aries	69.23	2.00e-164	572.00
IUUC-Ptr-090792	Pan troglodytes	97.49	0.00e+00	872.00
IUUC-Pan-092897	Papio anubis	98.33	0.00e+00	881.00
IUUC-Pab-098716	Pongo abelii	97.49	0.00e+00	872.00
IUUC-Pca-100618	Procavia capensis	82.67	0.00e+00	757.00
IUUC-Pva-102430	Pteropus vampyrus	83.09	0.00e+00	748.00
IUUC-Rno-105665	Rattus norvegicus	89.77	0.00e+00	847.00
IUUC-Sha-106854	Sarcophilus harrisii	65.77	1.00e-174	606.00
IUUC-Sar-113028	Sorex araneus	87.78	9.00e-139	486.00
IUUC-Ssc-116124	Sus scrofa	92.29	0.00e+00	831.00
IUUC-Tbe-127273	Tupaia belangeri	88.79	6.00e-119	421.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence