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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106366
Ensembl Protein ID YIL008W
UniProt Accession P40554; D6VVS2; URM1_YEAST
Genbank Protein ID CAA86243.1; AAS56621.1; DAA08538.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID Z38113; AY558295; BK006942
Gene Name URM1; YIL008W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YIL008W YIL008W YIL008W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 14551258; 14555475
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Indirectly involved in regulation of budding and haploid invasive growth.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Indirectly involved in regulation of budding and haploid invasive growth.
Protein Sequence
(Fasta)
MVNVKVEFLG GLDAIFGKQR VHKIKMDKED PVTVGDLIDH IVSTMINNPN DVSIFIEDDS 60
IRPGIITLIN DTDWELEGEK DYILEDGDII SFTSTLHGG 99
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Protein Fasta Sequence


>IUUC-Sce-106366|ULD,UBQ_Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGTAAACG TGAAAGTGGA GTTTCTAGGT GGACTTGATG CTATTTTTGG AAAACAAAGA 60
GTACATAAAA TTAAGATGGA CAAAGAAGAT CCTGTCACAG TGGGCGATTT GATTGACCAC 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106366|ULD,UBQ_Other|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0031386--F:protein tag
GO:0007114--P:cell budding
GO:0034599--P:cellular response to oxidative stress
GO:0001403--P:invasive growth in response to glucose limitation
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002143--P:tRNA wobble position uridine thiolation
GO:0002098--P:tRNA wobble uridine modification
KEGG sce:YIL008W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 41.41 8.00e-18 79.70
IUUC-Atr-003089 Amborella trichopoda 37.62 5.00e-16 73.90
IUUC-Apl-003382 Anas platyrhynchos 38.71 8.00e-16 72.80
IUUC-Aca-004981 Anolis carolinensis 40.40 3.00e-17 77.80
IUUC-Aly-005517 Arabidopsis lyrata 38.71 3.00e-16 73.90
IUUC-Ath-006718 Arabidopsis thaliana 39.76 8.00e-15 69.70
IUUC-Ago-007917 Ashbya gossypii 71.00 2.00e-38 148.00
IUUC-Acl-008054 Aspergillus clavatus 61.70 1.00e-13 65.10
IUUC-Afl-008704 Aspergillus flavus 37.63 1.00e-14 68.60
IUUC-Aor-009890 Aspergillus oryzae 39.62 3.00e-18 81.60
IUUC-Bta-012448 Bos taurus 41.41 8.00e-18 79.70
IUUC-Bci-013865 Botrytis cinerea 47.06 2.00e-22 95.10
IUUC-Bdi-014980 Brachypodium distachyon 43.02 4.00e-13 64.30
IUUC-Bol-016055 Brassica oleracea 39.29 3.00e-14 67.80
IUUC-Bra-016845 Brassica rapa 39.29 3.00e-14 67.80
IUUC-Cel-018485 Caenorhabditis elegans 33.00 6.00e-11 57.00
IUUC-Cja-019587 Callithrix jacchus 42.42 4.00e-18 80.50
IUUC-Cfa-020653 Canis familiaris 42.42 6.00e-18 80.10
IUUC-Cpo-021622 Cavia porcellus 42.42 4.00e-18 80.50
IUUC-Cre-023015 Chlamydomonas reinhardtii 40.59 6.00e-19 83.60
IUUC-Csa-023756 Chlorocebus sabaeus 36.84 4.00e-10 55.10
IUUC-Cho-025084 Choloepus hoffmanni 25.84 2.00e-01 27.70
IUUC-Csv-025947 Ciona savignyi 25.58 9.90e-02 27.30
IUUC-Cgl-026518 Colletotrichum gloeosporioides 40.20 3.00e-18 81.30
IUUC-Cne-026953 Cryptococcus neoformans 42.72 1.00e-15 73.20
IUUC-Cme-027314 Cyanidioschyzon merolae 42.00 2.00e-16 74.70
IUUC-Dre-027884 Danio rerio 39.39 1.00e-16 75.50
IUUC-Dno-029262 Dasypus novemcinctus 35.96 5.00e-11 58.50
IUUC-Dor-030601 Dipodomys ordii 54.35 4.00e-07 43.90
IUUC-Dme-031893 Drosophila melanogaster 36.73 1.00e-16 76.30
IUUC-Ete-032773 Echinops telfairi 42.27 2.00e-16 74.70
IUUC-Eca-034187 Equus caballus 43.43 3.00e-18 81.30
IUUC-Eeu-034808 Erinaceus europaeus 43.43 1.00e-18 82.00
IUUC-Fca-036107 Felis catus 42.42 1.00e-17 79.30
IUUC-Fal-036607 Ficedula albicollis 37.63 3.00e-15 70.90
IUUC-Fox-037698 Fusarium oxysporum 44.12 3.00e-21 91.70
IUUC-Gmo-039492 Gadus morhua 35.35 2.00e-14 68.60
IUUC-Ggr-039965 Gaeumannomyces graminis 41.18 1.00e-19 86.70
IUUC-Gga-041268 Gallus gallus 39.39 2.00e-17 78.20
IUUC-Gac-042111 Gasterosteus aculeatus 39.39 1.00e-16 75.90
IUUC-Gma-043240 Glycine max 35.71 5.00e-14 67.00
IUUC-Ggo-045176 Gorilla gorilla 36.84 5.00e-08 48.10
IUUC-Hsa-046077 Homo sapiens 42.42 1.00e-15 72.80
IUUC-Itr-048111 Ictidomys tridecemlineatus 63.04 2.00e-13 64.70
IUUC-Kpa-049157 Komagataella pastoris 56.57 6.00e-28 113.00
IUUC-Lch-049889 Latimeria chalumnae 38.38 3.00e-16 74.70
IUUC-Lpe-050783 Leersia perrieri 39.02 1.00e-12 62.80
IUUC-Loc-052400 Lepisosteus oculatus 37.37 1.00e-15 72.40
IUUC-Lma-053259 Leptosphaeria maculans 40.20 8.00e-20 86.70
IUUC-Laf-053596 Loxodonta africana 41.58 2.00e-17 78.20
IUUC-Mcc-054845 Macaca mulatta 40.22 3.00e-15 70.90
IUUC-Meu-055968 Macropus eugenii 44.44 3.00e-19 84.30
IUUC-Mor-057126 Magnaporthe oryzae 44.12 9.00e-21 90.10
IUUC-Mpo-057311 Magnaporthe poae 43.69 5.00e-20 88.20
IUUC-Mtr-058266 Medicago truncatula 38.67 5.00e-14 67.00
IUUC-Mla-058847 Melampsora laricipopulina 37.86 2.00e-14 68.90
IUUC-Mga-059468 Meleagris gallopavo 38.71 9.00e-16 72.40
IUUC-Mvi-060235 Microbotryum violaceum 53.97 3.00e-15 72.00
IUUC-Mdo-061948 Monodelphis domestica 45.45 2.00e-19 84.70
IUUC-Mmu-063946 Mus musculus 44.44 1.00e-18 82.40
IUUC-Mac-064812 Musa acuminata 46.48 5.00e-13 63.50
IUUC-Mpu-066763 Mustela putorius furo 44.44 6.00e-19 83.20
IUUC-Mlu-066970 Myotis lucifugus 36.84 2.00e-10 55.10
IUUC-Ncr-068824 Neurospora crassa 42.72 2.00e-21 91.70
IUUC-Nle-069849 Nomascus leucogenys 36.84 3.00e-10 55.50
IUUC-Opr-070227 Ochotona princeps 42.42 4.00e-18 80.50
IUUC-Ont-072530 Oreochromis niloticus 38.38 2.00e-16 75.50
IUUC-Oan-073191 Ornithorhynchus anatinus 42.86 2.00e-15 71.20
IUUC-Ocu-074460 Oryctolagus cuniculus 42.42 8.00e-18 79.70
IUUC-Oba-075499 Oryza barthii 40.96 7.00e-13 64.30
IUUC-Obr-076896 Oryza brachyantha 39.76 5.00e-12 62.40
IUUC-Ogl-077834 Oryza glaberrima 40.96 3.00e-13 64.30
IUUC-Ogu-078622 Oryza glumaepatula 40.96 3.00e-13 64.30
IUUC-Oin-079358 Oryza indica 40.96 1.00e-12 63.90
IUUC-Olo-081035 Oryza longistaminata 38.38 4.00e-14 68.60
IUUC-Oni-082425 Oryza nivara 40.96 3.00e-13 64.30
IUUC-Opu-083461 Oryza punctata 40.24 5.00e-12 61.60
IUUC-Oru-084875 Oryza rufipogon 51.06 3.00e-10 53.90
IUUC-Oga-089128 Otolemur garnettii 43.43 2.00e-18 81.30
IUUC-Oar-089896 Ovis aries 41.41 8.00e-18 79.70
IUUC-Ptr-091618 Pan troglodytes 36.84 5.00e-08 48.10
IUUC-Pan-092238 Papio anubis 36.84 4.00e-10 55.10
IUUC-Psi-093879 Pelodiscus sinensis 38.38 3.00e-16 74.30
IUUC-Pma-094484 Petromyzon marinus 45.68 6.00e-15 70.10
IUUC-Ppa-095801 Physcomitrella patens 38.10 1.00e-12 62.40
IUUC-Pfo-097192 Poecilia formosa 40.40 9.00e-16 72.80
IUUC-Pab-098203 Pongo abelii 42.42 2.00e-15 71.60
IUUC-Pop-099614 Populus trichocarpa 44.29 4.00e-14 67.40
IUUC-Pca-100507 Procavia capensis 35.53 2.00e-10 54.30
IUUC-Ppe-101174 Prunus persica 35.64 4.00e-17 77.00
IUUC-Pva-102735 Pteropus vampyrus 42.42 3.00e-15 70.90
IUUC-Pgr-103510 Puccinia graminis 36.54 2.00e-13 65.50
IUUC-Ptt-103918 Puccinia triticina 37.50 1.00e-14 69.70
IUUC-Pte-104173 Pyrenophora teres 39.22 2.00e-19 85.10
IUUC-Pyt-104806 Pyrenophora triticirepentis 39.22 2.00e-19 85.10
IUUC-Rno-105820 Rattus norvegicus 43.43 4.00e-18 80.90
IUUC-Sja-107727 Schizosaccharomyces japonicus 43.30 2.00e-18 82.00
IUUC-Spo-108074 Schizosaccharomyces pombe 44.79 6.00e-16 73.60
IUUC-Smo-108944 Selaginella moellendorffii 37.78 6.00e-15 69.70
IUUC-Sit-110277 Setaria italica 42.17 4.00e-14 67.40
IUUC-Sly-111505 Solanum lycopersicum 38.55 1.00e-13 65.90
IUUC-Stu-112076 Solanum tuberosum 38.55 1.00e-13 65.90
IUUC-Sar-113350 Sorex araneus 35.29 5.10e-01 27.70
IUUC-Sbi-114274 Sorghum bicolor 42.25 8.00e-13 63.20
IUUC-Sre-114953 Sporisorium reilianum 44.23 3.00e-19 84.30
IUUC-Ssc-115418 Sus scrofa 44.44 4.00e-18 80.50
IUUC-Tgu-117311 Taeniopygia guttata 37.63 2.00e-15 71.20
IUUC-Tru-118598 Takifugu rubripes 37.36 3.00e-14 67.40
IUUC-Tni-120109 Tetraodon nigroviridis 37.00 6.00e-13 63.50
IUUC-Tca-120942 Theobroma cacao 37.35 4.00e-13 63.90
IUUC-Tre-122099 Trichoderma reesei 44.68 6.00e-14 66.60
IUUC-Tvi-122285 Trichoderma virens 45.10 3.00e-16 74.70
IUUC-Tae-125193 Triticum aestivum 45.78 1.00e-15 72.00
IUUC-Tur-126677 Triticum urartu 41.05 7.00e-13 63.50
IUUC-Tme-127120 Tuber melanosporum 46.08 5.00e-24 100.00
IUUC-Tbe-128050 Tupaia belangeri 36.36 1.00e-11 59.30
IUUC-Ttr-129019 Tursiops truncatus 40.82 5.00e-17 77.00
IUUC-Uma-129483 Ustilago maydis 42.31 4.00e-18 80.90
IUUC-Vda-129690 Verticillium dahliae 36.61 2.00e-14 68.60
IUUC-Vvi-131174 Vitis vinifera 39.76 4.00e-15 70.50
IUUC-Xma-133862 Xiphophorus maculatus 40.40 9.00e-16 72.80
IUUC-Yli-134398 Yarrowia lipolytica 43.56 2.00e-19 85.10
IUUC-Zma-134964 Zea mays 40.48 3.00e-13 64.30
Created Date 25-Jun-2017

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