iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013416

Ensembl Protein ID

ENSBTAP00000018787.5

UniProt Accession

A5PKK9; FAP20_BOVIN

Genbank Protein ID

AAI42526.1

Protein Name

Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa

Genbank Nucleotide ID

BC142525

Gene Name

FAAP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000014136.5	ENSBTAT00000018787.5	ENSBTAP00000018787.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	46.95	7.00e-22	101.00	IUUC-Hsa-046575

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity).

Protein Sequence
(Fasta)

MEATRRSRLS LSRRRPPLGV RPRSNTAGSL PDGGECAKLW TELLRTASAD LNVDGELPPL 60
PAFPDQEPRR SPERPPPETF TVGTETFFWT PFPAPSPGRG GNSGGSDLVL SAVRGRTGSP 120

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Nucleotide Sequence
(Fasta)

GGCGCGCCGG CCGCTCATTT CCGCCGGACG TGGGGCGTCT GGGTGGATGG AGGCTACGCG 60
GAGGTCGCGG CTGAGTCTGA GCCGCCGGAG GCCGCCCTTG GGGGTCCGGT GAGGTTGGGG 120

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Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031491--FANCA_interact
IPR031490--UBZ_FAAP20

Pfam

PF15751--FANCA_interact
PF15750--UBZ_FAAP20

Gene Ontology

GO:0005694--C:chromosome
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0036297--P:interstrand cross-link repair
GO:0019985--P:translesion synthesis

KEGG

bta:508039

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000521	Aegilops tauschii	52.38	1.20e+00	26.20
IUUC-Aml-002409	Ailuropoda melanoleuca	47.92	5.00e-06	42.00
IUUC-Cja-019117	Callithrix jacchus	49.08	3.00e-24	105.00
IUUC-Cpo-021546	Cavia porcellus	48.48	2.00e-13	67.00
IUUC-Csa-024066	Chlorocebus sabaeus	48.19	1.00e-27	115.00
IUUC-Dno-029273	Dasypus novemcinctus	55.56	5.00e-14	69.30
IUUC-Ete-033066	Echinops telfairi	37.65	5.00e-21	93.60
IUUC-Eca-033947	Equus caballus	52.00	8.00e-22	96.70
IUUC-Eeu-034567	Erinaceus europaeus	48.37	3.00e-26	110.00
IUUC-Gac-041654	Gasterosteus aculeatus	40.26	1.00e-10	58.50
IUUC-Ggo-045315	Gorilla gorilla	49.38	1.00e-26	113.00
IUUC-Hsa-046575	Homo sapiens	49.39	3.00e-28	117.00
IUUC-Itr-048140	Ictidomys tridecemlineatus	47.75	1.00e-20	92.40
IUUC-Laf-054078	Loxodonta africana	46.96	1.00e-17	82.80
IUUC-Mmr-060675	Microcebus murinus	49.70	2.00e-32	130.00
IUUC-Mmu-063902	Mus musculus	44.03	1.00e-20	92.40
IUUC-Nle-069135	Nomascus leucogenys	50.00	8.00e-29	119.00
IUUC-Oga-088370	Otolemur garnettii	55.97	2.00e-35	141.00
IUUC-Oar-090037	Ovis aries	91.76	2.00e-39	156.00
IUUC-Ptr-091600	Pan troglodytes	48.99	2.00e-23	101.00
IUUC-Pan-091731	Papio anubis	47.51	1.00e-27	115.00
IUUC-Pfo-096538	Poecilia formosa	55.26	3.00e-08	50.80
IUUC-Pab-098384	Pongo abelii	50.64	4.00e-27	115.00
IUUC-Pca-100684	Procavia capensis	42.31	4.00e-22	97.80
IUUC-Rno-105623	Rattus norvegicus	45.57	5.00e-23	100.00
IUUC-Sha-107222	Sarcophilus harrisii	44.44	3.00e-10	57.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence