iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046677

UUCD1 version

UUC-HoS-00454

Ensembl Protein ID

ENSP00000263666.4

UniProt Accession

Q9UPQ7; A7MCZ6; Q8N2N7; Q96CC2; Q9NSQ2; PZRN3_HUMAN

Genbank Protein ID

BAA83047.1; AAH14432.1; AAI52418.1; BAC11068.1; CAB75679.1

Protein Name

E3 ubiquitin-protein ligase PDZRN3; Ligand of Numb protein X 3; PDZ domain-containing RING finger protein 3; RING-type E3 ubiquitin transferase PDZRN3; Semaphorin cytoplasmic domain-associated protein 3

Genbank Nucleotide ID

AB029018; BC014432; BC152417; AK074573; AL157498

Gene Name

PDZRN3; KIAA1095; LNX3; SEMCAP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000121440.14	ENST00000494559.5	ENSP00000419095.1
ENSG00000121440.14	ENST00000263666.8	ENSP00000263666.4
ENSG00000121440.14	ENST00000479530.5	ENSP00000418624.1
ENSG00000121440.14	ENST00000492909.1	ENSP00000419250.1
ENSG00000121440.14	ENST00000308537.4	ENSP00000308831.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17576800

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	7.80e-06	28.0	18	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCP.lC 45
           Ca+C+  ++d pl++pCgHvf+a C+  w        +e +CP  C
   Q: 18   CALCHKVLED-PLTTPCGHVFCAGCVLPW------VVQEGSCPaRC 56
           **********.******************......88888888445 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.

Protein Sequence
(Fasta)

MGFELDRFDG DVDPDLKCAL CHKVLEDPLT TPCGHVFCAG CVLPWVVQEG SCPARCRGRL 60
SAKELNHVLP LKRLILKLDI KCAYATRGCG RVVKLQQLPE HLERCDFAPA RCRHAGCGQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCGGGGAG AGCCAGCGAG CGCGCGGGCG GCGTAGCCGG CCTGTCTGGG CCGCCTCGTG 60
GGGAGGGAGG GGGCGCCCGG CCGCCCGGCG GCGACCCCGG GGCCTGGCCG CCACCATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001478--PDZ
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50106--PDZ
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00595--PDZ

SMART

SM00228--PDZ
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007528--P:neuromuscular junction development
GO:0016567--P:protein ubiquitination

KEGG

hsa:23024

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001910	Ailuropoda melanoleuca	91.76	0.00e+00	1546.00
IUUC-Apl-003623	Anas platyrhynchos	85.52	0.00e+00	1328.00
IUUC-Ame-011171	Astyanax mexicanus	48.85	0.00e+00	716.00
IUUC-Bta-012364	Bos taurus	92.06	0.00e+00	1869.00
IUUC-Cja-019726	Callithrix jacchus	98.31	0.00e+00	1580.00
IUUC-Cpo-021680	Cavia porcellus	93.64	0.00e+00	1903.00
IUUC-Csa-023684	Chlorocebus sabaeus	98.87	0.00e+00	2051.00
IUUC-Cho-024555	Choloepus hoffmanni	76.70	2.00e-108	387.00
IUUC-Dre-027462	Danio rerio	71.64	0.00e+00	1427.00
IUUC-Dno-029974	Dasypus novemcinctus	97.59	4.00e-47	180.00
IUUC-Dor-031125	Dipodomys ordii	89.60	0.00e+00	1737.00
IUUC-Ete-032745	Echinops telfairi	82.55	0.00e+00	885.00
IUUC-Eca-034276	Equus caballus	94.63	0.00e+00	1514.00
IUUC-Fal-037334	Ficedula albicollis	79.31	0.00e+00	1561.00
IUUC-Gmo-038706	Gadus morhua	70.06	0.00e+00	1363.00
IUUC-Gga-040586	Gallus gallus	82.87	0.00e+00	1610.00
IUUC-Gac-041605	Gasterosteus aculeatus	68.57	0.00e+00	1355.00
IUUC-Ggo-044706	Gorilla gorilla	99.72	0.00e+00	2070.00
IUUC-Itr-048660	Ictidomys tridecemlineatus	89.12	0.00e+00	1796.00
IUUC-Lch-049637	Latimeria chalumnae	68.08	1.00e-127	448.00
IUUC-Loc-052305	Lepisosteus oculatus	75.66	0.00e+00	1527.00
IUUC-Mcc-055573	Macaca mulatta	99.06	0.00e+00	2059.00
IUUC-Meu-056805	Macropus eugenii	82.36	0.00e+00	1653.00
IUUC-Mdo-062581	Monodelphis domestica	85.74	0.00e+00	1737.00
IUUC-Mmu-063597	Mus musculus	94.47	0.00e+00	1928.00
IUUC-Mpu-065685	Mustela putorius furo	94.59	0.00e+00	1440.00
IUUC-Mlu-067150	Myotis lucifugus	73.62	0.00e+00	1015.00
IUUC-Nle-068997	Nomascus leucogenys	99.81	0.00e+00	2040.00
IUUC-Ont-071534	Oreochromis niloticus	70.22	0.00e+00	1357.00
IUUC-Ola-086381	Oryzias latipes	68.50	0.00e+00	1368.00
IUUC-Oga-089068	Otolemur garnettii	95.50	0.00e+00	1924.00
IUUC-Oar-089252	Ovis aries	97.78	2.00e-79	288.00
IUUC-Pan-092366	Papio anubis	99.06	0.00e+00	2058.00
IUUC-Pfo-096576	Poecilia formosa	67.64	1.00e-122	432.00
IUUC-Pab-098239	Pongo abelii	99.34	0.00e+00	2063.00
IUUC-Pca-100484	Procavia capensis	90.40	0.00e+00	895.00
IUUC-Rno-105931	Rattus norvegicus	93.91	0.00e+00	1944.00
IUUC-Tgu-116615	Taeniopygia guttata	79.48	3.00e-108	384.00
IUUC-Tru-118175	Takifugu rubripes	71.27	0.00e+00	1395.00
IUUC-Tsy-119569	Tarsius syrichta	88.31	0.00e+00	1464.00
IUUC-Tbe-127819	Tupaia belangeri	89.64	0.00e+00	1434.00
IUUC-Ttr-128328	Tursiops truncatus	92.79	0.00e+00	1492.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence