iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088177

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03125056

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000003101.2	ENSOGAT00000003107.2	ENSOGAP00000002779.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-121	406.5	1240	1572

Active Site

Position(s)	Description	Evidence
1540	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1240 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1325
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1326 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1408
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1409 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1495
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1496 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
           **************************************************************************985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MALQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIGES MKWTCKSRNV KGCQQPGGRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTAGCT CAGCCCGGGA GCATCTGCTT TTTGTGCGGC GTCGAAATCC CCAGATGCGG 60
TACACACTGA GCCCGGAGAA CCTCCAGAGC CTGGCCGCCC AGAGCTCCAT GCCGGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	93.46	0.00e+00	2866.00
IUUC-Apl-003935	Anas platyrhynchos	84.21	0.00e+00	2650.00
IUUC-Aca-004558	Anolis carolinensis	81.47	0.00e+00	2574.00
IUUC-Ame-010893	Astyanax mexicanus	88.47	0.00e+00	1307.00
IUUC-Bta-013093	Bos taurus	96.47	0.00e+00	1583.00
IUUC-Cja-019651	Callithrix jacchus	93.12	0.00e+00	2760.00
IUUC-Cfa-021232	Canis familiaris	99.24	0.00e+00	1630.00
IUUC-Cpo-021770	Cavia porcellus	88.34	0.00e+00	2741.00
IUUC-Csa-023970	Chlorocebus sabaeus	94.29	0.00e+00	2858.00
IUUC-Cho-024512	Choloepus hoffmanni	86.23	0.00e+00	2534.00
IUUC-Csv-026127	Ciona savignyi	66.67	4.00e-155	541.00
IUUC-Dre-028275	Danio rerio	85.65	0.00e+00	1487.00
IUUC-Dno-029963	Dasypus novemcinctus	92.00	0.00e+00	2683.00
IUUC-Dor-030282	Dipodomys ordii	86.98	0.00e+00	1898.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	659.00
IUUC-Ete-033132	Echinops telfairi	83.18	0.00e+00	1264.00
IUUC-Eca-033978	Equus caballus	93.46	0.00e+00	2843.00
IUUC-Eeu-035278	Erinaceus europaeus	61.85	0.00e+00	1129.00
IUUC-Fca-036157	Felis catus	93.40	0.00e+00	2848.00
IUUC-Fal-037110	Ficedula albicollis	81.90	0.00e+00	2337.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1018.00
IUUC-Gga-040821	Gallus gallus	84.18	0.00e+00	2644.00
IUUC-Gac-042181	Gasterosteus aculeatus	83.94	0.00e+00	1435.00
IUUC-Ggo-044862	Gorilla gorilla	94.25	0.00e+00	2741.00
IUUC-Hsa-046219	Homo sapiens	94.54	0.00e+00	2898.00
IUUC-Lch-050526	Latimeria chalumnae	76.61	0.00e+00	2377.00
IUUC-Loc-052648	Lepisosteus oculatus	87.76	0.00e+00	1531.00
IUUC-Laf-054005	Loxodonta africana	93.34	0.00e+00	2882.00
IUUC-Mcc-055314	Macaca mulatta	94.35	0.00e+00	2849.00
IUUC-Meu-056356	Macropus eugenii	66.38	0.00e+00	1051.00
IUUC-Mga-060074	Meleagris gallopavo	83.85	0.00e+00	2537.00
IUUC-Mmr-061526	Microcebus murinus	94.92	0.00e+00	2857.00
IUUC-Mdo-063017	Monodelphis domestica	89.48	0.00e+00	2740.00
IUUC-Mmu-064165	Mus musculus	92.54	0.00e+00	2819.00
IUUC-Mpu-065835	Mustela putorius furo	82.06	0.00e+00	1556.00
IUUC-Mlu-067709	Myotis lucifugus	87.96	0.00e+00	2682.00
IUUC-Nle-069308	Nomascus leucogenys	93.91	0.00e+00	2858.00
IUUC-Opr-070330	Ochotona princeps	80.33	0.00e+00	2320.00
IUUC-Ont-071345	Oreochromis niloticus	87.44	0.00e+00	1451.00
IUUC-Ocu-074775	Oryctolagus cuniculus	94.58	0.00e+00	2624.00
IUUC-Ola-087225	Oryzias latipes	62.99	0.00e+00	1789.00
IUUC-Oar-089452	Ovis aries	94.10	0.00e+00	2864.00
IUUC-Ptr-090806	Pan troglodytes	94.35	0.00e+00	2884.00
IUUC-Pan-091838	Papio anubis	94.25	0.00e+00	2736.00
IUUC-Psi-094090	Pelodiscus sinensis	83.83	0.00e+00	2617.00
IUUC-Pfo-096520	Poecilia formosa	64.54	0.00e+00	1904.00
IUUC-Pab-098405	Pongo abelii	94.29	0.00e+00	2866.00
IUUC-Pca-100441	Procavia capensis	87.11	0.00e+00	2203.00
IUUC-Pva-102324	Pteropus vampyrus	98.87	0.00e+00	1626.00
IUUC-Rno-105943	Rattus norvegicus	91.97	0.00e+00	2892.00
IUUC-Sha-106985	Sarcophilus harrisii	87.64	0.00e+00	2337.00
IUUC-Sar-113505	Sorex araneus	95.45	0.00e+00	1542.00
IUUC-Ssc-115439	Sus scrofa	91.59	0.00e+00	1862.00
IUUC-Tgu-117078	Taeniopygia guttata	91.74	0.00e+00	1771.00
IUUC-Tru-118671	Takifugu rubripes	83.96	0.00e+00	1450.00
IUUC-Tni-120619	Tetraodon nigroviridis	84.62	0.00e+00	1431.00
IUUC-Tbe-127975	Tupaia belangeri	90.92	0.00e+00	2362.00
IUUC-Ttr-128469	Tursiops truncatus	87.94	0.00e+00	2576.00
IUUC-Vpa-130498	Vicugna pacos	83.07	0.00e+00	2353.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence