iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089953

Ensembl Protein ID

ENSOARP00000017249.1

UniProt Accession

W5Q3G0; W5Q3G0_SHEEP

Genbank Protein ID

ENSOARP00000017249

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01080214

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000016063.1	ENSOART00000017493.1	ENSOARP00000017249.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-97	325.8	270	674

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+           ++        +                                    
   Q: 270  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnrwlavtaSD--------Ktrssykhppvtdtvyqmnecqekepysvrfrhpsls 350
           7******************************8888777665522........1233334457788888888888888899999999999 PP
   S: 43   .....................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkke 110
                                +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy qqDaqEfl+ lld+++ el   
   Q: 351  sglsggapqsrkmeliqprepSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYGQQDAQEFLCELLDKIQHEL--- 436
           99999999888888888877777777************************************************************... PP
   S: 111  knkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLe 192
                 e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ ++  +        ++++L+
   Q: 437  ------ETTGTRLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCIGKdsasqpcLVTEMLA 519
           ......7788888999999************************************************655554445555555******* PP
   S: 193  sftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ 
   Q: 520  KFTETEALEGKI-YVCDQCNSKRRrfsskpvllteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRESL 606
           *********965.*******999999999****99***********************998.7778********************998 PP
   S: 271  kqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+ +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 607  KSLRpeCFLYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 674
           8876779***************************9999********************...********98 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MLTMDKCQHI GQLRLAQDHS ILNPQKWHCV DCNTTESIWA CLSCSHVACG RSIEEHALGH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKNQNY HCTTRSGKVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGGGGGGC GCGTGGAGGA GGAGGGGGCG GCAGCGGCGG CGGCAGGTCC GGCGAATTTA 60
GAATTGGCGC CTCTGGAAAG TTAAGGTGGG TCGAGCGATG CCCAGGCCGG TGCCGACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101117743

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	92.84	0.00e+00	1332.00
IUUC-Apl-003673	Anas platyrhynchos	75.74	0.00e+00	1066.00
IUUC-Aca-004434	Anolis carolinensis	72.38	0.00e+00	1042.00
IUUC-Ame-010986	Astyanax mexicanus	64.29	0.00e+00	878.00
IUUC-Bta-012774	Bos taurus	97.46	0.00e+00	1373.00
IUUC-Cja-019619	Callithrix jacchus	89.48	0.00e+00	1276.00
IUUC-Cfa-020957	Canis familiaris	91.57	0.00e+00	1336.00
IUUC-Csa-023177	Chlorocebus sabaeus	89.62	0.00e+00	1274.00
IUUC-Cho-024877	Choloepus hoffmanni	88.89	0.00e+00	838.00
IUUC-Cin-025587	Ciona intestinalis	48.97	3.00e-108	386.00
IUUC-Csv-025814	Ciona savignyi	46.22	4.00e-157	548.00
IUUC-Dre-027878	Danio rerio	64.16	0.00e+00	846.00
IUUC-Dno-029832	Dasypus novemcinctus	91.01	0.00e+00	1313.00
IUUC-Ete-032627	Echinops telfairi	86.41	0.00e+00	1234.00
IUUC-Eca-033863	Equus caballus	87.27	0.00e+00	1237.00
IUUC-Eeu-035225	Erinaceus europaeus	84.97	0.00e+00	1213.00
IUUC-Fca-036288	Felis catus	92.42	0.00e+00	1330.00
IUUC-Fal-037207	Ficedula albicollis	74.68	0.00e+00	1029.00
IUUC-Gga-040457	Gallus gallus	74.79	0.00e+00	1026.00
IUUC-Gac-042595	Gasterosteus aculeatus	54.22	0.00e+00	707.00
IUUC-Ggo-044926	Gorilla gorilla	89.06	0.00e+00	1266.00
IUUC-Hsa-046079	Homo sapiens	88.50	0.00e+00	1263.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	90.17	0.00e+00	1283.00
IUUC-Lch-050260	Latimeria chalumnae	67.79	0.00e+00	941.00
IUUC-Loc-051981	Lepisosteus oculatus	77.26	0.00e+00	677.00
IUUC-Laf-054491	Loxodonta africana	88.12	0.00e+00	1215.00
IUUC-Mcc-055694	Macaca mulatta	90.04	0.00e+00	1275.00
IUUC-Mga-059523	Meleagris gallopavo	74.75	0.00e+00	1041.00
IUUC-Mmr-060885	Microcebus murinus	91.88	0.00e+00	1308.00
IUUC-Mdo-063018	Monodelphis domestica	79.04	0.00e+00	1119.00
IUUC-Mmu-064012	Mus musculus	78.23	0.00e+00	1088.00
IUUC-Mpu-066207	Mustela putorius furo	91.29	0.00e+00	1336.00
IUUC-Mlu-066929	Myotis lucifugus	87.97	0.00e+00	1200.00
IUUC-Nle-069313	Nomascus leucogenys	79.06	0.00e+00	1092.00
IUUC-Opr-070375	Ochotona princeps	79.69	0.00e+00	1108.00
IUUC-Ont-071637	Oreochromis niloticus	63.38	0.00e+00	855.00
IUUC-Oan-073030	Ornithorhynchus anatinus	77.72	0.00e+00	857.00
IUUC-Ocu-074836	Oryctolagus cuniculus	86.92	0.00e+00	1216.00
IUUC-Oga-088367	Otolemur garnettii	91.88	0.00e+00	1284.00
IUUC-Ptr-090980	Pan troglodytes	88.64	0.00e+00	1264.00
IUUC-Pan-092748	Papio anubis	90.31	0.00e+00	1283.00
IUUC-Psi-094078	Pelodiscus sinensis	75.91	0.00e+00	849.00
IUUC-Pma-094155	Petromyzon marinus	71.22	6.00e-81	293.00
IUUC-Pfo-096413	Poecilia formosa	54.25	0.00e+00	722.00
IUUC-Pab-098514	Pongo abelii	88.92	0.00e+00	1268.00
IUUC-Pva-102984	Pteropus vampyrus	89.73	0.00e+00	1283.00
IUUC-Rno-106019	Rattus norvegicus	79.75	0.00e+00	1133.00
IUUC-Sha-106965	Sarcophilus harrisii	77.86	0.00e+00	1117.00
IUUC-Ssc-115299	Sus scrofa	92.84	0.00e+00	1348.00
IUUC-Tgu-117160	Taeniopygia guttata	74.05	0.00e+00	1023.00
IUUC-Tru-118156	Takifugu rubripes	61.47	0.00e+00	832.00
IUUC-Tsy-118814	Tarsius syrichta	60.09	0.00e+00	787.00
IUUC-Tni-119733	Tetraodon nigroviridis	62.54	0.00e+00	854.00
IUUC-Tbe-128084	Tupaia belangeri	84.43	0.00e+00	1210.00
IUUC-Ttr-128928	Tursiops truncatus	94.51	0.00e+00	1365.00
IUUC-Vpa-130706	Vicugna pacos	93.12	0.00e+00	1338.00
IUUC-Xtr-132061	Xenopus tropicalis	69.98	0.00e+00	944.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence