iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074836

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02034289

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000004663.3	ENSOCUT00000004663.3	ENSOCUP00000004028.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-97	327.0	269	673

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                      +                                   
   Q: 269  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavttsD---------Ktrsykhpavtdtvahqmnecqekdigyvrsrhpsl 348
           7******************************8776666554331.........133444566777777788888888889999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 349  ssglsggasksrkmeliqarepSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL-- 435
           999999888888888887777667777************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L
   Q: 436  -------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCNGKdnasqpcLVTEML 517
           .......7889999999999************************************************888776667777788****** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg + y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++
   Q: 518  AKFTETEVLEG-KVYVCDQCNSKRRrfspkpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRET 604
           **********9.56*******999999999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 605  LKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 673
           88876779***************************9999********************...********98 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MDKCRHIGQL RLSQDHSTLN PQKWHCVDCN TTESIWACLS CPHVACGRYI EEHALRHFEE 60
SSHPVALEVN EMNVFCYLCD DYVLNDNAAG DLKLLRSTLS AIKSQNHHCT TRSRRILRPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGGACAA AAGCTGTGAC TGCATAATAA TGTACTGCTG GCGGTGGGGG AGGGGGACCT 60
GGAAGGCTCC TAGTTCCTAG GAAAGCAGTT TCCTGGAGGT GAAAGTTTAG GCCGGGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100347648

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	87.89	0.00e+00	1246.00
IUUC-Apl-003673	Anas platyrhynchos	73.70	0.00e+00	1000.00
IUUC-Aca-004434	Anolis carolinensis	72.26	0.00e+00	983.00
IUUC-Ame-010986	Astyanax mexicanus	63.14	0.00e+00	838.00
IUUC-Bta-012774	Bos taurus	85.49	0.00e+00	1193.00
IUUC-Cja-019619	Callithrix jacchus	87.31	0.00e+00	1224.00
IUUC-Cfa-020957	Canis familiaris	86.34	0.00e+00	1242.00
IUUC-Csa-023177	Chlorocebus sabaeus	87.89	0.00e+00	1222.00
IUUC-Cho-024877	Choloepus hoffmanni	84.78	0.00e+00	787.00
IUUC-Cin-025587	Ciona intestinalis	47.53	2.00e-109	390.00
IUUC-Csv-025814	Ciona savignyi	46.09	1.00e-152	533.00
IUUC-Dre-027878	Danio rerio	62.27	0.00e+00	821.00
IUUC-Dno-029832	Dasypus novemcinctus	87.73	0.00e+00	1253.00
IUUC-Ete-032627	Echinops telfairi	83.54	0.00e+00	1178.00
IUUC-Eca-033863	Equus caballus	83.24	0.00e+00	1150.00
IUUC-Eeu-035225	Erinaceus europaeus	82.25	0.00e+00	1117.00
IUUC-Fca-036288	Felis catus	87.61	0.00e+00	1243.00
IUUC-Fal-037207	Ficedula albicollis	72.91	0.00e+00	977.00
IUUC-Gmo-039249	Gadus morhua	68.99	2.00e-130	459.00
IUUC-Gga-040457	Gallus gallus	72.78	0.00e+00	977.00
IUUC-Gac-042595	Gasterosteus aculeatus	52.79	0.00e+00	699.00
IUUC-Ggo-044926	Gorilla gorilla	88.01	0.00e+00	1224.00
IUUC-Hsa-046079	Homo sapiens	87.59	0.00e+00	1217.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	86.88	0.00e+00	1219.00
IUUC-Lch-050260	Latimeria chalumnae	66.15	0.00e+00	876.00
IUUC-Loc-051981	Lepisosteus oculatus	75.40	0.00e+00	666.00
IUUC-Laf-054491	Loxodonta africana	85.80	0.00e+00	1154.00
IUUC-Mcc-055694	Macaca mulatta	87.89	0.00e+00	1219.00
IUUC-Mga-059523	Meleagris gallopavo	72.92	0.00e+00	996.00
IUUC-Mmr-060885	Microcebus murinus	89.30	0.00e+00	1257.00
IUUC-Mdo-063018	Monodelphis domestica	76.30	0.00e+00	1046.00
IUUC-Mmu-064012	Mus musculus	77.25	0.00e+00	1056.00
IUUC-Mpu-066207	Mustela putorius furo	86.06	0.00e+00	1246.00
IUUC-Mlu-066929	Myotis lucifugus	84.46	0.00e+00	1127.00
IUUC-Nle-069313	Nomascus leucogenys	77.99	0.00e+00	1035.00
IUUC-Opr-070375	Ochotona princeps	82.96	0.00e+00	1117.00
IUUC-Ont-071637	Oreochromis niloticus	63.35	0.00e+00	826.00
IUUC-Oan-073030	Ornithorhynchus anatinus	75.09	0.00e+00	791.00
IUUC-Ola-086413	Oryzias latipes	54.13	6.00e-162	563.00
IUUC-Oga-088367	Otolemur garnettii	88.31	0.00e+00	1226.00
IUUC-Oar-089953	Ovis aries	86.92	0.00e+00	1236.00
IUUC-Ptr-090980	Pan troglodytes	87.87	0.00e+00	1222.00
IUUC-Pan-092748	Papio anubis	88.31	0.00e+00	1221.00
IUUC-Pfo-096413	Poecilia formosa	52.48	0.00e+00	720.00
IUUC-Pab-098514	Pongo abelii	88.03	0.00e+00	1217.00
IUUC-Pva-102984	Pteropus vampyrus	87.18	0.00e+00	1211.00
IUUC-Rno-106019	Rattus norvegicus	78.46	0.00e+00	1101.00
IUUC-Sha-106965	Sarcophilus harrisii	76.82	0.00e+00	1040.00
IUUC-Ssc-115299	Sus scrofa	86.76	0.00e+00	1247.00
IUUC-Tgu-117160	Taeniopygia guttata	72.99	0.00e+00	974.00
IUUC-Tru-118156	Takifugu rubripes	58.49	0.00e+00	799.00
IUUC-Tni-119733	Tetraodon nigroviridis	60.55	0.00e+00	817.00
IUUC-Tbe-128084	Tupaia belangeri	82.68	0.00e+00	1176.00
IUUC-Ttr-128928	Tursiops truncatus	88.73	0.00e+00	1247.00
IUUC-Vpa-130706	Vicugna pacos	87.75	0.00e+00	1230.00
IUUC-Xtr-132061	Xenopus tropicalis	69.31	0.00e+00	897.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence