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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046555
Ensembl Protein ID ENSP00000349967.4
UniProt Accession O00421; B4DKQ8; O75307; Q4VBB0; Q6IPX0; Q7KYQ9; Q96KP5; Q9UPG0; CCRL2_HUMAN
Genbank Protein ID AAC39595.1; AAB82106.1; AAC34601.1; AAC34602.1; CAC82985.1; BAG59270.1; AAQ76789.1; AAB57794.1; AAH25717.1; AAH71682.1; AAH96075.1; AAH96076.1; AAH99623.1
Protein Name C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor
Genbank Nucleotide ID U97123; AF014958; AF015524; AF015525; AJ344142; AK296673; AY337001; U95626; BC025717; BC071682; BC096075; BC096076; BC099623
Gene Name CCRL2; CCR11; CCR6; CKRX; CRAM; HCR
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000121797.9 ENST00000357392.4 ENSP00000349967.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 21.93 5.30e-01 30.00 IUUC-Spo-108231
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
Protein Sequence
(Fasta)
MIYTRFLKGS LKMANYTLAP EDEYDVLIEG ELESDEAEQC DKYDAQALSA QLVPSLCSAV 60
FVIGVLDNLL VVLILVKYKG LKRVENIYLL NLAVSNLCFL LTLPFWAHAG GDPMCKILIG 120
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Protein Fasta Sequence



>IUUC-Hsa-046555|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
CTCAGAAGGC CAGAAGACGG CTGTCAAAGG TCACAGGGAA ATCAAAGGCG GGGTACAGGG 60
CCAGAGGGAG GAGGAAACAA CTTCCCGGTT GCTTTCAGAC GCTTCAGAGA TCCTCTGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046555|E3,F-box|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR000355--Chemokine_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM

PROSITE

PS50262--G_PROTEIN_RECEP_F1_2

Pfam

PF00001--7tm_1

PRINTS

PR00657--CCCHEMOKINER
PR00237--GPCRRHODOPSN

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0048020--F:CCR chemokine receptor binding
GO:0004950--F:chemokine receptor activity
GO:0042379--F:chemokine receptor binding
GO:0006935--P:chemotaxis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006954--P:inflammatory response

KEGG hsa:9034
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ggo-045592 Gorilla gorilla 98.03 0.00e+00 688.00
IUUC-Pfo-096201 Poecilia formosa 28.37 2.00e-05 43.90
Created Date 25-Jun-2017

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