iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063373

UUCD1 version

UUC-MuM-00063

Ensembl Protein ID

ENSMUSP00000078024.6

UniProt Accession

Q9DBD2; MARH8_MOUSE

Genbank Protein ID

BAB23759.1; BAE32966.1; AAH50908.1; AAH53090.1

Protein Name

E3 ubiquitin-protein ligase MARCH8; Cellular modulator of immune recognition; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING-type E3 ubiquitin transferase MARCH8

Genbank Nucleotide ID

AK005032; AK154976; BC050908; BC053090

Gene Name

March8; Mir

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000025702.15	ENSMUST00000079012.12	ENSMUSP00000078024.6
ENSMUSG00000025702.15	ENSMUST00000123405.7	ENSMUSP00000144936.1
ENSMUSG00000025702.15	ENSMUST00000135901.1	ENSMUSP00000115510.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19117940

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.11	14.1	76	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg.plvlpC.....gHvfhadClqkwpglknssskefrCPlCr 46
           C iC+++ +d+ pl++pC      H+ h+ Clq+w     +ss +  C lC+
   Q: 76   CRICHCEGDDEsPLITPChctgsLHFVHQACLQQW----IKSSDTRCCELCK 123
           ****88885555*****9445444888********....8899999*****6 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS (By similarity).

Protein Sequence
(Fasta)

MSMPLHQISA IPSQDAISAR VYRSKTKDKE QNEKTLGHSM SHPSNISKAG SSPPSTTAPV 60
SAFSRTSVTP SNQDICRICH CEGDDESPLI TPCHCTGSLH FVHQACLQQW IKSSDTRCCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGGCGTCCT CTCGCTGGGT GGTGTAGGCT GCGCGCTGAC CCAGCGGCCC TGCTGCGTCC 60
GGCCCGGGTC ATGCAGGAAG CGGGCCGCGC GTGGAGCTCC GCGCCCACCT GAGCTGCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1064--Adaptive immunity
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0042289--F:MHC class II protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0002495--P:antigen processing and presentation of peptide antigen via MHC class II
GO:0045347--P:negative regulation of MHC class II biosynthetic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination

KEGG

mmu:71779

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013415	Bos taurus	87.59	1.00e-144	505.00
IUUC-Cel-018329	Caenorhabditis elegans	40.26	3.00e-11	63.50
IUUC-Cfa-020901	Canis familiaris	86.21	1.00e-141	495.00
IUUC-Cpo-021679	Cavia porcellus	90.27	5.00e-139	486.00
IUUC-Csa-023704	Chlorocebus sabaeus	85.22	3.00e-140	490.00
IUUC-Dre-027670	Danio rerio	78.97	1.00e-125	442.00
IUUC-Dno-028902	Dasypus novemcinctus	84.14	3.00e-140	490.00
IUUC-Dme-031717	Drosophila melanogaster	56.63	2.00e-60	226.00
IUUC-Eca-033918	Equus caballus	87.61	1.00e-124	438.00
IUUC-Gmo-039585	Gadus morhua	78.28	7.00e-125	439.00
IUUC-Gga-040516	Gallus gallus	86.81	1.00e-144	505.00
IUUC-Gac-041554	Gasterosteus aculeatus	77.93	7.00e-125	439.00
IUUC-Hsa-045936	Homo sapiens	86.60	4.00e-142	497.00
IUUC-Lch-049853	Latimeria chalumnae	80.69	6.00e-133	466.00
IUUC-Loc-052142	Lepisosteus oculatus	76.27	1.00e-123	435.00
IUUC-Laf-054075	Loxodonta africana	89.33	3.00e-120	424.00
IUUC-Mcc-054834	Macaca mulatta	85.57	1.00e-140	492.00
IUUC-Mmr-061603	Microcebus murinus	88.97	9.00e-151	525.00
IUUC-Mdo-062578	Monodelphis domestica	85.57	7.00e-143	499.00
IUUC-Nle-069774	Nomascus leucogenys	85.91	2.00e-140	491.00
IUUC-Ocu-074342	Oryctolagus cuniculus	78.20	4.00e-121	427.00
IUUC-Ola-086344	Oryzias latipes	77.91	1.00e-113	402.00
IUUC-Oga-088670	Otolemur garnettii	88.76	7.00e-132	462.00
IUUC-Ptr-090574	Pan troglodytes	87.29	4.00e-143	500.00
IUUC-Pan-092925	Papio anubis	84.88	1.00e-139	489.00
IUUC-Psi-093085	Pelodiscus sinensis	85.86	1.00e-135	475.00
IUUC-Pma-094229	Petromyzon marinus	63.90	4.00e-73	267.00
IUUC-Pfo-097524	Poecilia formosa	78.57	2.00e-117	415.00
IUUC-Pab-098165	Pongo abelii	86.25	1.00e-141	495.00
IUUC-Rno-105837	Rattus norvegicus	100.00	3.00e-160	556.00
IUUC-Sha-107014	Sarcophilus harrisii	85.78	2.00e-117	415.00
IUUC-Tru-117951	Takifugu rubripes	76.14	6.00e-106	376.00
IUUC-Tni-120496	Tetraodon nigroviridis	76.95	2.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence