iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068917

Ensembl Protein ID

EAA32973

UniProt Accession

P33288; Q7RVG1; RAD18_NEUCR

Genbank Protein ID

BAA02015.1; EAA32973.2

Protein Name

Postreplication repair E3 ubiquitin-protein ligase rad18; RING-type E3 ubiquitin transferase rad18; UV radiation sensitivity protein 2

Genbank Nucleotide ID

D11458; CM002239

Gene Name

uvs-2; rad18; NCU05210

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU05210	EAA32973	EAA32973

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.10e-07	28.7	28	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceen 72
           v ++f+C + ++    P+ +++++t+   +I+++l+ + k cP++r++ +e++l  n +lr+ ++a+ +++
   Q: 28   VEQAFRCHVCKDFYDSPMLTSCNHTFCSLCIRRCLSVDSK-CPLCRATDQESKLRGNWALREAVEAFKNSR 97
           5689***********************************9.*************************98776 PP

Organism

Neurospora crassa

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.

Protein Sequence
(Fasta)

MDVFGDEAFN VPDSTDWLGT PLACLMPVEQ AFRCHVCKDF YDSPMLTSCN HTFCSLCIRR 60
CLSVDSKCPL CRATDQESKL RGNWALREAV EAFKNSRKVL LEFARTPPTI QAILPDQAGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAATGGAA TTCTCCTCCT CGACAAAGTC GCGACCAGTC TCGTCCGACT TGCAGACATC 60
GCGTCTCACA TCTTCCGTCT CTTCTACAAT ACTACTTCCA GGCTTCCAGG TAGAACGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003684--F:damaged DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006301--P:postreplication repair
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV

KEGG

ncr:NCU05210

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	26.20	1.00e-24	106.00
IUUC-Apl-003657	Anas platyrhynchos	34.11	1.00e-17	82.40
IUUC-Aca-005369	Anolis carolinensis	30.30	3.00e-16	75.90
IUUC-Aly-006466	Arabidopsis lyrata	41.82	7.00e-07	47.00
IUUC-Ath-006986	Arabidopsis thaliana	32.81	6.00e-10	58.20
IUUC-Ago-007876	Ashbya gossypii	28.82	3.00e-30	124.00
IUUC-Acl-008246	Aspergillus clavatus	43.24	6.00e-71	259.00
IUUC-Afl-008666	Aspergillus flavus	42.53	5.00e-77	279.00
IUUC-Afu-009052	Aspergillus fumigatus	42.97	2.00e-74	271.00
IUUC-Ani-009488	Aspergillus nidulans	42.97	8.00e-77	278.00
IUUC-Ang-009681	Aspergillus niger	44.47	5.00e-81	292.00
IUUC-Aor-010037	Aspergillus oryzae	44.50	8.00e-81	292.00
IUUC-Ate-010516	Aspergillus terreus	53.49	2.00e-39	153.00
IUUC-Ame-010630	Astyanax mexicanus	25.44	1.00e-29	122.00
IUUC-Bgr-012178	Blumeria graminis	39.68	3.00e-70	256.00
IUUC-Bta-012976	Bos taurus	38.10	3.00e-14	71.20
IUUC-Bci-013680	Botrytis cinerea	40.84	1.00e-74	271.00
IUUC-Bdi-014168	Brachypodium distachyon	40.62	4.00e-08	51.60
IUUC-Bol-016476	Brassica oleracea	31.25	1.00e-09	57.00
IUUC-Bra-017176	Brassica rapa	29.52	2.00e-11	62.80
IUUC-Cel-018356	Caenorhabditis elegans	34.67	2.00e-10	56.60
IUUC-Cja-019453	Callithrix jacchus	26.95	6.00e-26	110.00
IUUC-Cfa-020856	Canis familiaris	24.63	2.00e-25	108.00
IUUC-Cpo-021950	Cavia porcellus	26.65	7.00e-29	120.00
IUUC-Csa-023997	Chlorocebus sabaeus	36.90	3.00e-14	71.20
IUUC-Cho-024771	Choloepus hoffmanni	38.46	2.00e-13	68.60
IUUC-Cin-025364	Ciona intestinalis	31.08	2.00e-10	57.80
IUUC-Cgl-026668	Colletotrichum gloeosporioides	51.05	3.00e-87	313.00
IUUC-Cme-027202	Cyanidioschyzon merolae	32.98	2.00e-13	68.20
IUUC-Dre-028479	Danio rerio	27.02	4.00e-24	103.00
IUUC-Dno-028943	Dasypus novemcinctus	35.71	1.00e-13	69.30
IUUC-Dor-031046	Dipodomys ordii	31.11	3.00e-11	61.20
IUUC-Dse-031235	Dothistroma septosporum	34.30	1.00e-33	135.00
IUUC-Ete-032503	Echinops telfairi	24.51	1.00e-15	75.50
IUUC-Eca-033725	Equus caballus	24.95	4.00e-25	107.00
IUUC-Eeu-034573	Erinaceus europaeus	37.66	3.00e-12	64.70
IUUC-Fca-036495	Felis catus	24.11	1.00e-25	108.00
IUUC-Fal-036791	Ficedula albicollis	27.16	2.00e-20	91.70
IUUC-Fox-037868	Fusarium oxysporum	43.87	3.00e-74	270.00
IUUC-Fso-038144	Fusarium solani	51.09	1.00e-86	311.00
IUUC-Gmo-039152	Gadus morhua	26.16	3.00e-24	104.00
IUUC-Ggr-039737	Gaeumannomyces graminis	54.41	2.00e-54	204.00
IUUC-Gga-040788	Gallus gallus	35.16	5.00e-14	70.90
IUUC-Gac-041993	Gasterosteus aculeatus	28.48	2.00e-28	118.00
IUUC-Ggo-044889	Gorilla gorilla	36.90	2.00e-14	71.60
IUUC-Hsa-045957	Homo sapiens	36.90	2.00e-14	71.60
IUUC-Itr-048998	Ictidomys tridecemlineatus	36.90	5.00e-14	70.50
IUUC-Kpa-049300	Komagataella pastoris	24.06	6.00e-20	89.70
IUUC-Lch-050172	Latimeria chalumnae	42.25	4.00e-13	66.60
IUUC-Loc-052609	Lepisosteus oculatus	27.99	2.00e-23	101.00
IUUC-Lma-053037	Leptosphaeria maculans	35.97	8.00e-56	209.00
IUUC-Laf-053889	Loxodonta africana	24.48	3.00e-22	97.80
IUUC-Mcc-055853	Macaca mulatta	35.71	2.00e-13	68.90
IUUC-Meu-056866	Macropus eugenii	28.47	2.00e-17	82.00
IUUC-Mor-057071	Magnaporthe oryzae	49.68	2.00e-101	360.00
IUUC-Mpo-057628	Magnaporthe poae	53.59	1.00e-54	205.00
IUUC-Mla-058953	Melampsora laricipopulina	21.67	6.00e-18	84.00
IUUC-Mga-059687	Meleagris gallopavo	28.34	9.00e-23	99.40
IUUC-Mvi-060412	Microbotryum violaceum	24.36	5.00e-21	94.00
IUUC-Mmr-061563	Microcebus murinus	24.87	7.00e-11	60.10
IUUC-Mdo-062655	Monodelphis domestica	36.90	6.00e-14	70.50
IUUC-Mmu-063647	Mus musculus	35.71	3.00e-13	68.20
IUUC-Mpu-065778	Mustela putorius furo	24.61	5.00e-25	107.00
IUUC-Mlu-068205	Myotis lucifugus	34.94	1.00e-12	66.20
IUUC-Nfi-068501	Neosartorya fischeri	43.78	1.00e-75	274.00
IUUC-Nle-068990	Nomascus leucogenys	36.90	2.00e-14	71.60
IUUC-Opr-071146	Ochotona princeps	37.89	5.00e-15	73.90
IUUC-Ont-071835	Oreochromis niloticus	28.48	9.00e-28	115.00
IUUC-Oan-072827	Ornithorhynchus anatinus	32.48	5.00e-15	72.40
IUUC-Ocu-073986	Oryctolagus cuniculus	28.62	2.00e-25	108.00
IUUC-Ome-081927	Oryza meridionalis	38.81	9.00e-10	55.50
IUUC-Ola-086997	Oryzias latipes	39.56	7.00e-15	72.80
IUUC-Olu-087771	Ostreococcus lucimarinus	28.71	2.00e-20	91.70
IUUC-Oga-088092	Otolemur garnettii	24.88	2.00e-27	115.00
IUUC-Oar-089651	Ovis aries	38.10	2.00e-14	72.40
IUUC-Ptr-091103	Pan troglodytes	36.90	2.00e-14	71.60
IUUC-Pan-092478	Papio anubis	34.94	5.00e-13	67.40
IUUC-Psi-093356	Pelodiscus sinensis	35.56	4.00e-14	70.90
IUUC-Pfo-096663	Poecilia formosa	29.77	8.00e-14	69.70
IUUC-Pab-098515	Pongo abelii	36.90	3.00e-14	71.60
IUUC-Pca-100588	Procavia capensis	32.22	4.00e-10	57.40
IUUC-Pva-102377	Pteropus vampyrus	24.32	3.00e-22	97.80
IUUC-Pgr-103556	Puccinia graminis	27.95	2.00e-19	89.00
IUUC-Pte-104362	Pyrenophora teres	35.68	2.00e-56	211.00
IUUC-Pyt-104823	Pyrenophora triticirepentis	37.38	4.00e-29	120.00
IUUC-Rno-105866	Rattus norvegicus	35.71	4.00e-13	67.80
IUUC-Sce-106454	Saccharomyces cerevisiae	38.95	4.00e-18	84.30
IUUC-Sha-107515	Sarcophilus harrisii	37.80	1.00e-14	72.40
IUUC-Sja-107689	Schizosaccharomyces japonicus	48.89	3.00e-22	97.80
IUUC-Spo-108248	Schizosaccharomyces pombe	27.86	2.00e-40	157.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	40.94	1.00e-71	262.00
IUUC-Smo-109268	Selaginella moellendorffii	39.39	2.00e-07	50.10
IUUC-Stu-112154	Solanum tuberosum	29.69	1.00e-07	50.40
IUUC-Sar-113220	Sorex araneus	39.13	4.00e-07	47.40
IUUC-Sre-115123	Sporisorium reilianum	32.45	1.00e-14	72.40
IUUC-Ssc-115992	Sus scrofa	24.52	2.00e-10	58.20
IUUC-Tgu-117286	Taeniopygia guttata	32.82	1.00e-11	62.40
IUUC-Tru-117959	Takifugu rubripes	26.09	1.00e-21	95.90
IUUC-Tsy-119286	Tarsius syrichta	39.29	2.00e-09	55.10
IUUC-Tni-120570	Tetraodon nigroviridis	27.94	1.00e-23	102.00
IUUC-Tre-121893	Trichoderma reesei	44.04	4.00e-83	300.00
IUUC-Tvi-122405	Trichoderma virens	48.93	1.00e-83	301.00
IUUC-Tbe-127758	Tupaia belangeri	35.90	1.00e-12	65.90
IUUC-Ttr-128841	Tursiops truncatus	25.86	2.00e-24	105.00
IUUC-Uma-129563	Ustilago maydis	35.92	3.00e-12	64.70
IUUC-Vda-130021	Verticillium dahliae	54.81	1.00e-37	147.00
IUUC-Vpa-130169	Vicugna pacos	38.27	5.00e-14	70.50
IUUC-Xtr-132308	Xenopus tropicalis	27.13	6.00e-27	112.00
IUUC-Xma-133868	Xiphophorus maculatus	28.66	3.00e-26	110.00
IUUC-Yli-134474	Yarrowia lipolytica	27.73	9.00e-33	132.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence