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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064008
Ensembl Protein ID ENSMUSP00000019135.7
UniProt Accession Q8BMI3; Q3V1Y0; Q80U71; GGA3_MOUSE
Genbank Protein ID BAC65494.2; BAC27246.1; BAE21019.1; CAM23010.1
Protein Name ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3
Genbank Nucleotide ID AK122212; AK031086; AK132183; AL645470
Gene Name Gga3; Kiaa0154
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020740.13 ENSMUST00000019135.13 ENSMUSP00000019135.7
ENSMUSG00000020740.13 ENSMUST00000106508.9 ENSMUSP00000102117.3
ENSMUSG00000020740.13 ENSMUST00000156173.7 ENSMUSP00000138597.1
ENSMUSG00000020740.13 ENSMUST00000125097.1 ENSMUSP00000118024.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/GAT 3.40e-48 164.0 171 297
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/GAT
   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeepednellqelyetckaar 89
           deeksklL+rLlksk+P+DL+eAn+Lik++vkede++++k++k++++leev++nvkll eml ++s+e ++++d+el++el+++c+++r
   Q: 171  DEEKSKLLARLLKSKNPDDLQEANRLIKSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEYSSDADKELMKELFDRCENKR 259
           79*************************************************************************************** PP
   S: 90   pkllklieeeedndellaellkanDelnqvlnkykqlk 127
           ++l+kl++e+ednd++l+++l+a+D+l++v+n+yk+++
   Q: 260  RTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTII 297
           ***********************************997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).
 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).
Protein Sequence
(Fasta)
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW 60
EAVQALTVLE ACMKNCGRRL HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLFS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064008|UBD,GAT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGGTTCCC TCTGAGGAAG AAGCGAAGAC ACATCCTCGC CCTCGCGGCC TCCGACGCGG 60
TCCGGCGCGC CCGTGGACCG CAGCCCTCGG CGCGCTCAGG CCCCCATGCG GGCCCCGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064008|UBD,GAT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR027422--GGA3
IPR002014--VHS_dom
PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS
Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS
SMART

SM00809--Alpha_adaptinC2
SM00288--VHS
Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0005802--C:trans-Golgi network
GO:0030306--F:ADP-ribosylation factor binding
GO:0006886--P:intracellular protein transport
GO:0045732--P:positive regulation of protein catabolic process
GO:0016192--P:vesicle-mediated transport
KEGG mmu:260302
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002322 Ailuropoda melanoleuca 83.36 0.00e+00 925.00
IUUC-Apl-003683 Anas platyrhynchos 69.57 0.00e+00 805.00
IUUC-Aca-004859 Anolis carolinensis 83.69 1.00e-137 483.00
IUUC-Ame-010868 Astyanax mexicanus 73.87 2.00e-130 459.00
IUUC-Bta-013431 Bos taurus 73.05 0.00e+00 630.00
IUUC-Cel-018437 Caenorhabditis elegans 27.78 9.00e-34 138.00
IUUC-Cja-019158 Callithrix jacchus 84.84 0.00e+00 986.00
IUUC-Cfa-020509 Canis familiaris 82.49 0.00e+00 966.00
IUUC-Cpo-021520 Cavia porcellus 84.45 0.00e+00 989.00
IUUC-Csa-023292 Chlorocebus sabaeus 84.84 0.00e+00 991.00
IUUC-Cho-025040 Choloepus hoffmanni 86.50 4.00e-74 271.00
IUUC-Cin-025211 Ciona intestinalis 55.22 2.00e-91 330.00
IUUC-Csv-026066 Ciona savignyi 55.70 1.00e-99 357.00
IUUC-Dre-028244 Danio rerio 70.27 4.00e-131 462.00
IUUC-Dno-029654 Dasypus novemcinctus 92.24 6.00e-170 591.00
IUUC-Ete-033003 Echinops telfairi 76.80 5.00e-125 441.00
IUUC-Eca-034436 Equus caballus 83.31 0.00e+00 996.00
IUUC-Eeu-034519 Erinaceus europaeus 88.86 3.00e-172 598.00
IUUC-Fca-035372 Felis catus 81.64 0.00e+00 918.00
IUUC-Fal-037437 Ficedula albicollis 69.11 0.00e+00 800.00
IUUC-Gmo-038952 Gadus morhua 72.97 3.00e-139 488.00
IUUC-Gga-041130 Gallus gallus 70.86 0.00e+00 839.00
IUUC-Gac-041460 Gasterosteus aculeatus 71.56 9.00e-137 481.00
IUUC-Ggo-044495 Gorilla gorilla 82.68 0.00e+00 991.00
IUUC-Hsa-046184 Homo sapiens 85.11 0.00e+00 1002.00
IUUC-Itr-048345 Ictidomys tridecemlineatus 86.65 0.00e+00 1009.00
IUUC-Lch-049582 Latimeria chalumnae 66.09 0.00e+00 779.00
IUUC-Loc-051903 Lepisosteus oculatus 76.79 1.00e-135 477.00
IUUC-Laf-054207 Loxodonta africana 82.55 0.00e+00 929.00
IUUC-Mcc-055642 Macaca mulatta 81.83 0.00e+00 993.00
IUUC-Meu-056386 Macropus eugenii 68.61 1.00e-109 390.00
IUUC-Mga-060101 Meleagris gallopavo 70.45 0.00e+00 808.00
IUUC-Mmr-060937 Microcebus murinus 85.66 0.00e+00 995.00
IUUC-Mdo-062835 Monodelphis domestica 72.83 0.00e+00 725.00
IUUC-Mpu-066397 Mustela putorius furo 82.54 0.00e+00 914.00
IUUC-Mlu-067731 Myotis lucifugus 85.50 0.00e+00 1058.00
IUUC-Nle-069975 Nomascus leucogenys 79.30 4.00e-137 481.00
IUUC-Opr-070313 Ochotona princeps 78.50 0.00e+00 836.00
IUUC-Ont-072399 Oreochromis niloticus 72.75 2.00e-139 489.00
IUUC-Ocu-074749 Oryctolagus cuniculus 78.68 0.00e+00 954.00
IUUC-Ola-086409 Oryzias latipes 64.84 3.00e-130 459.00
IUUC-Oga-088203 Otolemur garnettii 83.03 0.00e+00 872.00
IUUC-Oar-089423 Ovis aries 80.80 0.00e+00 981.00
IUUC-Ptr-090623 Pan troglodytes 83.09 0.00e+00 878.00
IUUC-Pan-092274 Papio anubis 84.97 0.00e+00 987.00
IUUC-Psi-093397 Pelodiscus sinensis 68.61 0.00e+00 798.00
IUUC-Pma-094269 Petromyzon marinus 73.11 2.00e-109 388.00
IUUC-Pfo-096335 Poecilia formosa 70.15 2.00e-132 466.00
IUUC-Pab-097977 Pongo abelii 78.75 0.00e+00 913.00
IUUC-Pca-100991 Procavia capensis 75.07 0.00e+00 783.00
IUUC-Pva-102285 Pteropus vampyrus 83.33 0.00e+00 1021.00
IUUC-Rno-105106 Rattus norvegicus 94.09 0.00e+00 1132.00
IUUC-Sha-106548 Sarcophilus harrisii 73.96 0.00e+00 841.00
IUUC-Sja-107801 Schizosaccharomyces japonicus 24.64 9.00e-15 75.10
IUUC-Ssc-116343 Sus scrofa 81.06 0.00e+00 922.00
IUUC-Tgu-117119 Taeniopygia guttata 71.02 0.00e+00 828.00
IUUC-Tru-118049 Takifugu rubripes 74.75 2.00e-134 473.00
IUUC-Tsy-119623 Tarsius syrichta 78.55 0.00e+00 902.00
IUUC-Tni-120803 Tetraodon nigroviridis 51.04 0.00e+00 671.00
IUUC-Ttr-129167 Tursiops truncatus 77.13 0.00e+00 919.00
IUUC-Xtr-132922 Xenopus tropicalis 56.88 0.00e+00 749.00
Created Date 25-Jun-2017

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