iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003513

Ensembl Protein ID

ENSAPLP00000009626.1

UniProt Accession

U3IQV3; U3IQV3_ANAPL

Genbank Protein ID

ENSAPLP00000009626

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ADON01023575

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000009867.1	ENSAPLT00000010322.1	ENSAPLP00000009626.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-131	437.5	395	727

Active Site

Position(s)	Description	Evidence
696	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 395  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 482
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 483  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 567
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 568  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKANTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 655
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+++l+ekLl+Aieet gF +
   Q: 656  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYDKLYEKLLTAIEETCGFAV 727
           **********************************************************************76 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

TVLCAKNLVK KDFFRLPDPF AKVVVDGSGQ CHSTDTVKNT LDPKWNQHYD LYIGKSDSIT 60
ISVWNHKKIH KKQGAGFLGC VRLLSNAINR LKDTGYQRLD LCKLGPNDND TVRGQIVVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGTACTGT GTGCAAAAAA CTTGGTGAAA AAGGACTTTT TCCGTAAGTA GCTGTTAAAG 60
TTTTATATGT TTATAGTTGG GATAAATATT ATGCAAGCTC TGTAAATCCC TGTTTGCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	97.68	0.00e+00	1480.00
IUUC-Aca-005358	Anolis carolinensis	97.83	0.00e+00	1493.00
IUUC-Aly-006083	Arabidopsis lyrata	45.36	1.00e-91	332.00
IUUC-Ath-007472	Arabidopsis thaliana	45.36	2.00e-91	332.00
IUUC-Ame-011320	Astyanax mexicanus	89.07	0.00e+00	1387.00
IUUC-Bta-013399	Bos taurus	97.68	0.00e+00	1476.00
IUUC-Cja-019355	Callithrix jacchus	97.55	0.00e+00	1477.00
IUUC-Cpo-022200	Cavia porcellus	97.82	0.00e+00	1482.00
IUUC-Cho-024804	Choloepus hoffmanni	98.38	0.00e+00	640.00
IUUC-Cin-025126	Ciona intestinalis	67.29	0.00e+00	976.00
IUUC-Csv-026339	Ciona savignyi	65.19	0.00e+00	1004.00
IUUC-Dre-027650	Danio rerio	91.46	0.00e+00	1426.00
IUUC-Dno-029534	Dasypus novemcinctus	97.41	0.00e+00	1478.00
IUUC-Ete-032715	Echinops telfairi	92.21	0.00e+00	1389.00
IUUC-Eca-033580	Equus caballus	97.68	0.00e+00	1480.00
IUUC-Eeu-034945	Erinaceus europaeus	95.57	0.00e+00	1373.00
IUUC-Fal-037275	Ficedula albicollis	97.69	0.00e+00	1497.00
IUUC-Gga-041060	Gallus gallus	95.25	0.00e+00	1429.00
IUUC-Gac-041295	Gasterosteus aculeatus	92.42	0.00e+00	1420.00
IUUC-Hsa-046726	Homo sapiens	97.68	0.00e+00	1478.00
IUUC-Lch-050026	Latimeria chalumnae	95.66	0.00e+00	1451.00
IUUC-Loc-051760	Lepisosteus oculatus	89.40	0.00e+00	1403.00
IUUC-Laf-053753	Loxodonta africana	97.55	0.00e+00	1479.00
IUUC-Mcc-054815	Macaca mulatta	97.41	0.00e+00	1475.00
IUUC-Meu-056436	Macropus eugenii	74.86	0.00e+00	1080.00
IUUC-Mpo-057442	Magnaporthe poae	38.75	1.00e-146	513.00
IUUC-Mmr-060806	Microcebus murinus	97.68	0.00e+00	1479.00
IUUC-Mdo-062805	Monodelphis domestica	96.85	0.00e+00	1463.00
IUUC-Mmu-064034	Mus musculus	97.41	0.00e+00	1474.00
IUUC-Mpu-066762	Mustela putorius furo	97.68	0.00e+00	1479.00
IUUC-Mlu-066981	Myotis lucifugus	97.55	0.00e+00	1478.00
IUUC-Nle-069804	Nomascus leucogenys	97.68	0.00e+00	1477.00
IUUC-Opr-070591	Ochotona princeps	91.67	0.00e+00	1379.00
IUUC-Ont-071239	Oreochromis niloticus	93.37	0.00e+00	1431.00
IUUC-Oan-072699	Ornithorhynchus anatinus	94.18	0.00e+00	1469.00
IUUC-Ocu-074913	Oryctolagus cuniculus	97.68	0.00e+00	1480.00
IUUC-Ola-086597	Oryzias latipes	86.14	0.00e+00	1311.00
IUUC-Oga-089116	Otolemur garnettii	94.14	0.00e+00	1417.00
IUUC-Oar-089366	Ovis aries	97.54	0.00e+00	1476.00
IUUC-Ptr-091382	Pan troglodytes	97.68	0.00e+00	1478.00
IUUC-Psi-093298	Pelodiscus sinensis	97.82	0.00e+00	1475.00
IUUC-Pma-094354	Petromyzon marinus	73.74	0.00e+00	1117.00
IUUC-Pfo-096071	Poecilia formosa	90.86	0.00e+00	1419.00
IUUC-Pab-098682	Pongo abelii	97.68	0.00e+00	1479.00
IUUC-Pop-099520	Populus trichocarpa	45.57	2.00e-92	335.00
IUUC-Pca-100516	Procavia capensis	88.95	0.00e+00	630.00
IUUC-Pva-102754	Pteropus vampyrus	96.04	0.00e+00	1442.00
IUUC-Rno-105600	Rattus norvegicus	97.49	0.00e+00	1280.00
IUUC-Sha-107144	Sarcophilus harrisii	96.49	0.00e+00	1352.00
IUUC-Spo-108171	Schizosaccharomyces pombe	41.26	9.00e-164	570.00
IUUC-Sar-113122	Sorex araneus	86.34	0.00e+00	1263.00
IUUC-Tgu-117112	Taeniopygia guttata	97.42	0.00e+00	1483.00
IUUC-Tru-118497	Takifugu rubripes	90.23	0.00e+00	1364.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.92	0.00e+00	1189.00
IUUC-Tme-126897	Tuber melanosporum	39.92	2.00e-153	535.00
IUUC-Tbe-127371	Tupaia belangeri	87.28	0.00e+00	1188.00
IUUC-Ttr-129305	Tursiops truncatus	90.11	0.00e+00	1272.00
IUUC-Vpa-130591	Vicugna pacos	87.16	0.00e+00	1281.00
IUUC-Xtr-132979	Xenopus tropicalis	78.43	0.00e+00	1116.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence