iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098682

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01131789

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000008549.2	ENSPPYT00000009987.2	ENSPPYP00000009604.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-129	431.6	544	876

Active Site

Position(s)	Description	Evidence
845	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 544  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 631
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipV++eNk+eYv+l+v+
   Q: 632  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVN 716
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 717  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 804
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 805  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 876
           **********************************************************************76 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

AQSPAPAPPS TARLSRPAPS ATGPRRDERR ERPRRPRGGG GGAGGGGAGG RGCRFVVRGP 60
RKEKWEEGGA RRPAPSAAHG DDSRHIRDPP AVAAAAPAAR APAPAAVVTP PRLAVAPVPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCAGAGTC CTGCTCCGGC GCCGCCGAGC ACCGCCCGCC TCAGCCGACC AGCCCCGTCG 60
GCTACTGGGC CTCGCCGAGA CGAGAGGAGG GAAAGGCCTC GGCGGCCGCG AGGAGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	99.05	0.00e+00	1497.00
IUUC-Apl-003513	Anas platyrhynchos	97.68	0.00e+00	1479.00
IUUC-Aca-005358	Anolis carolinensis	97.21	0.00e+00	1502.00
IUUC-Ame-011320	Astyanax mexicanus	87.86	0.00e+00	1388.00
IUUC-Bta-013399	Bos taurus	99.45	0.00e+00	1490.00
IUUC-Cja-019355	Callithrix jacchus	98.40	0.00e+00	1503.00
IUUC-Cpo-022200	Cavia porcellus	99.45	0.00e+00	1502.00
IUUC-Cin-025126	Ciona intestinalis	65.79	0.00e+00	971.00
IUUC-Csv-026339	Ciona savignyi	64.91	0.00e+00	1005.00
IUUC-Dre-027650	Danio rerio	90.46	0.00e+00	1431.00
IUUC-Dno-029534	Dasypus novemcinctus	99.47	0.00e+00	1529.00
IUUC-Dme-031740	Drosophila melanogaster	71.91	3.00e-172	598.00
IUUC-Ete-032715	Echinops telfairi	94.66	0.00e+00	1409.00
IUUC-Eca-033580	Equus caballus	99.73	0.00e+00	1506.00
IUUC-Eeu-034945	Erinaceus europaeus	97.56	0.00e+00	1390.00
IUUC-Fal-037275	Ficedula albicollis	96.90	0.00e+00	1469.00
IUUC-Gga-041060	Gallus gallus	94.29	0.00e+00	1432.00
IUUC-Gac-041295	Gasterosteus aculeatus	91.67	0.00e+00	1399.00
IUUC-Hsa-046726	Homo sapiens	100.00	0.00e+00	1539.00
IUUC-Lch-050026	Latimeria chalumnae	95.49	0.00e+00	1466.00
IUUC-Loc-051760	Lepisosteus oculatus	88.52	0.00e+00	1374.00
IUUC-Laf-053753	Loxodonta africana	99.59	0.00e+00	1504.00
IUUC-Mcc-054815	Macaca mulatta	99.73	0.00e+00	1536.00
IUUC-Meu-056436	Macropus eugenii	75.40	0.00e+00	1107.00
IUUC-Mpo-057442	Magnaporthe poae	38.18	8.00e-146	511.00
IUUC-Mmr-060806	Microcebus murinus	99.45	0.00e+00	1499.00
IUUC-Mdo-062805	Monodelphis domestica	97.46	0.00e+00	1493.00
IUUC-Mmu-064034	Mus musculus	99.20	0.00e+00	1524.00
IUUC-Mpu-066762	Mustela putorius furo	99.05	0.00e+00	1496.00
IUUC-Mlu-066981	Myotis lucifugus	99.59	0.00e+00	1503.00
IUUC-Nle-069804	Nomascus leucogenys	100.00	0.00e+00	1527.00
IUUC-Opr-070591	Ochotona princeps	93.97	0.00e+00	1397.00
IUUC-Ont-071239	Oreochromis niloticus	91.99	0.00e+00	1409.00
IUUC-Oan-072699	Ornithorhynchus anatinus	95.71	0.00e+00	1497.00
IUUC-Ocu-074913	Oryctolagus cuniculus	99.47	0.00e+00	1537.00
IUUC-Ola-086597	Oryzias latipes	85.62	0.00e+00	1284.00
IUUC-Oga-089116	Otolemur garnettii	95.90	0.00e+00	1434.00
IUUC-Oar-089366	Ovis aries	99.18	0.00e+00	1492.00
IUUC-Ptr-091382	Pan troglodytes	100.00	0.00e+00	1539.00
IUUC-Psi-093298	Pelodiscus sinensis	97.96	0.00e+00	1457.00
IUUC-Pma-094354	Petromyzon marinus	73.51	0.00e+00	1125.00
IUUC-Pfo-096071	Poecilia formosa	90.40	0.00e+00	1421.00
IUUC-Pca-100516	Procavia capensis	75.77	0.00e+00	1193.00
IUUC-Pva-102754	Pteropus vampyrus	98.49	0.00e+00	1461.00
IUUC-Rno-105600	Rattus norvegicus	99.06	0.00e+00	1291.00
IUUC-Sha-107144	Sarcophilus harrisii	97.36	0.00e+00	1355.00
IUUC-Sar-113122	Sorex araneus	88.36	0.00e+00	1282.00
IUUC-Tgu-117112	Taeniopygia guttata	97.08	0.00e+00	1497.00
IUUC-Tru-118497	Takifugu rubripes	88.99	0.00e+00	1366.00
IUUC-Tsy-118819	Tarsius syrichta	99.03	0.00e+00	1038.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.77	0.00e+00	1179.00
IUUC-Tme-126897	Tuber melanosporum	39.30	4.00e-153	535.00
IUUC-Tbe-127371	Tupaia belangeri	89.28	0.00e+00	1219.00
IUUC-Ttr-129305	Tursiops truncatus	91.68	0.00e+00	1288.00
IUUC-Vpa-130591	Vicugna pacos	89.32	0.00e+00	1301.00
IUUC-Xtr-132979	Xenopus tropicalis	77.06	0.00e+00	1104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence