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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046468
UUCD1 version UUC-HoS-00374
Ensembl Protein ID ENSP00000354571.3
UniProt Accession Q9H920; B3KSW8; Q6IA57; Q6P449; Q96DB4; RN121_HUMAN
Genbank Protein ID BAB14423.1; BAG52880.1; CAG33579.1; EAW74810.1; AAH09672.2; AAH63680.1
Protein Name RING finger protein 121
Genbank Nucleotide ID AK023139; AK094508; CR457298; AP002490; BC009672; BC063680
Gene Name RNF121
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137522.17 ENST00000361756.7 ENSP00000354571.3
ENSG00000137522.17 ENST00000393711.7 ENSP00000377314.3
ENSG00000137522.17 ENST00000530655.5 ENSP00000432898.1
ENSG00000137522.17 ENST00000533380.5 ENSP00000433574.1
ENSG00000137522.17 ENST00000393713.7 ENSP00000377316.3
ENSG00000137522.17 ENST00000525243.5 ENSP00000435859.1
ENSG00000137522.17 ENST00000530137.1 ENSP00000431286.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDMentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
UniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20357004
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.30e-07 32.0 226 276
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..........kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C + +          ++ ++ l+C+Hvfh+ C+  w    +   k+++CP+C+
   Q: 226  CAVCGQQIfvdvseegiiEN-TYRLSCNHVFHEFCIRGW----CIVGKKQTCPYCK 276
           9***9888888887777655.777***************....889999******7 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAAVVEVEVG GGAAGERELD EVDMSDLSPE EQWRVEHARM HAKHRGHEAM HAEMVLILIA 60
TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH WWRFLVIWIL FSAVTAFVTF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046468|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGTCTCGCT CCTTGGAGCC CAGACTGAGG GAGCGTCGCG AAAGTTGCCC GTTTTGGAAC 60
GCTCCCATTT GGCTCTCCAA AGGGAAGAAT TGGTTAAATA GTTGCACTGA AAATAATGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046468|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:55298
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002350 Ailuropoda melanoleuca 98.71 3.00e-175 607.00
IUUC-Apl-003882 Anas platyrhynchos 86.82 2.00e-140 491.00
IUUC-Aca-004343 Anolis carolinensis 89.13 1.00e-22 97.10
IUUC-Aly-005550 Arabidopsis lyrata 37.10 2.00e-06 47.40
IUUC-Ame-010680 Astyanax mexicanus 83.73 6.00e-161 560.00
IUUC-Bta-013045 Bos taurus 99.32 2.00e-166 578.00
IUUC-Cel-018296 Caenorhabditis elegans 51.58 2.00e-99 355.00
IUUC-Cja-019866 Callithrix jacchus 99.03 9.00e-176 609.00
IUUC-Cfa-021176 Canis familiaris 97.76 3.00e-174 603.00
IUUC-Cpo-022268 Cavia porcellus 97.73 3.00e-172 597.00
IUUC-Cre-022649 Chlamydomonas reinhardtii 41.06 9.00e-55 206.00
IUUC-Csa-023727 Chlorocebus sabaeus 99.68 3.00e-176 610.00
IUUC-Cho-025016 Choloepus hoffmanni 99.04 8.00e-177 612.00
IUUC-Cin-025281 Ciona intestinalis 64.24 5.00e-125 440.00
IUUC-Csv-026338 Ciona savignyi 63.99 3.00e-113 401.00
IUUC-Dre-027836 Danio rerio 82.08 5.00e-143 500.00
IUUC-Dno-029737 Dasypus novemcinctus 97.76 8.00e-174 602.00
IUUC-Dor-031070 Dipodomys ordii 91.48 9.00e-155 539.00
IUUC-Dme-031867 Drosophila melanogaster 60.00 2.00e-113 402.00
IUUC-Ete-032964 Echinops telfairi 89.71 6.00e-166 576.00
IUUC-Eca-034398 Equus caballus 99.35 1.00e-175 608.00
IUUC-Fca-035807 Felis catus 99.03 5.00e-173 600.00
IUUC-Fal-036721 Ficedula albicollis 95.83 1.00e-158 551.00
IUUC-Gmo-039699 Gadus morhua 87.99 9.00e-150 522.00
IUUC-Gga-040840 Gallus gallus 96.25 3.00e-161 560.00
IUUC-Gac-042639 Gasterosteus aculeatus 83.13 3.00e-150 524.00
IUUC-Ggo-045576 Gorilla gorilla 100.00 3.00e-174 603.00
IUUC-Itr-048638 Ictidomys tridecemlineatus 98.78 7.00e-147 512.00
IUUC-Lch-050207 Latimeria chalumnae 82.14 2.00e-143 501.00
IUUC-Loc-052172 Lepisosteus oculatus 89.25 2.00e-160 558.00
IUUC-Laf-053879 Loxodonta africana 98.40 1.00e-176 612.00
IUUC-Mcc-055492 Macaca mulatta 99.68 3.00e-176 610.00
IUUC-Meu-055976 Macropus eugenii 82.35 4.00e-138 483.00
IUUC-Mga-059989 Meleagris gallopavo 93.97 8.00e-169 585.00
IUUC-Mmr-060894 Microcebus murinus 99.68 3.00e-176 610.00
IUUC-Mdo-061826 Monodelphis domestica 95.41 5.00e-166 577.00
IUUC-Mmu-063717 Mus musculus 98.70 4.00e-174 603.00
IUUC-Mpu-066826 Mustela putorius furo 99.35 6.00e-176 609.00
IUUC-Mlu-068081 Myotis lucifugus 95.11 5.00e-175 606.00
IUUC-Nle-069734 Nomascus leucogenys 99.68 3.00e-176 610.00
IUUC-Opr-070379 Ochotona princeps 95.82 3.00e-168 584.00
IUUC-Ont-071855 Oreochromis niloticus 83.13 2.00e-150 525.00
IUUC-Ocu-074363 Oryctolagus cuniculus 99.04 2.00e-176 611.00
IUUC-Ola-086489 Oryzias latipes 81.63 1.00e-148 518.00
IUUC-Oga-088323 Otolemur garnettii 99.35 6.00e-173 599.00
IUUC-Oar-090243 Ovis aries 98.39 7.00e-176 609.00
IUUC-Ptr-091374 Pan troglodytes 100.00 2.00e-176 611.00
IUUC-Pan-092115 Papio anubis 99.68 3.00e-176 610.00
IUUC-Psi-093658 Pelodiscus sinensis 95.68 7.00e-154 536.00
IUUC-Pfo-097261 Poecilia formosa 82.23 4.00e-149 520.00
IUUC-Pab-098579 Pongo abelii 100.00 2.00e-176 611.00
IUUC-Pca-100119 Procavia capensis 93.89 4.00e-161 560.00
IUUC-Pva-102111 Pteropus vampyrus 99.02 4.00e-173 600.00
IUUC-Rno-105364 Rattus norvegicus 98.39 1.00e-175 608.00
IUUC-Sha-107005 Sarcophilus harrisii 95.50 1.00e-172 598.00
IUUC-Sar-113163 Sorex araneus 99.35 5.00e-176 610.00
IUUC-Ssc-115633 Sus scrofa 95.60 3.00e-173 600.00
IUUC-Tgu-116869 Taeniopygia guttata 97.28 1.00e-163 568.00
IUUC-Tru-118217 Takifugu rubripes 81.55 9.00e-157 546.00
IUUC-Tsy-119308 Tarsius syrichta 99.03 3.00e-175 607.00
IUUC-Tni-119882 Tetraodon nigroviridis 83.18 4.00e-158 550.00
IUUC-Ttr-129087 Tursiops truncatus 99.35 4.00e-174 603.00
IUUC-Vpa-130785 Vicugna pacos 92.93 7.00e-163 566.00
IUUC-Xtr-132801 Xenopus tropicalis 90.83 1.00e-156 545.00
Created Date 25-Jun-2017

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