iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143258.15	ENST00000289865.12	ENSP00000289865.8
ENSG00000143258.15	ENST00000368001.1	ENSP00000356980.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20622874; 19910467

Classification

Family	E-value	Score	Start	End
DUB/USP	1.10e-90	306.0	212	556

Active Site

Position(s)	Description	Evidence
221	Nucleophile
518	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqq 90
           +Gl+NlgNtC++N+vLQcLs++++lr+++l+  ++++++     ++ +el++++++++ +lw  ++ +av+p+++ ++++k+ ++fsgy+qq
   Q: 212  VGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRrDFRQEVPG---GGRAQELTEAFADVIGALWhPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
           6******************************667777776...5789***************888899************************ PP
   S: 91   DaqEflaflldqleeelkk..................eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvss 164
           DaqEfl+ l+++l+ e+++                  ++     ee e ++ ++ +  +++  ++++s i+dlF gqlks +kc++c+ +s+
   Q: 301  DAQEFLKLLMERLHLEINRrgrrappilangpvpsppRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
           *****************9999999999999988877766666677777777777777*********************************** PP
   S: 165  reepfldlslpvpgkeet.kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
           ++e f+dlslp+p+k     k sl+dc++ ftkeeele+en+  c++c++k++++kkl+++++P++L+lhL+Rf  s +++s +k +  v+f
   Q: 393  TFEVFCDLSLPIPKKGFAgGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF--SASRGSIKKSSVGVDF 482
           *************887541456****************************************************..55668999******** PP
   S: 256  ple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           pl+ L+l  f +++      +  Y+L+a ++HsGs++ GHY+a+++  + +W  ++Ds+V++v+e++v +   s++YvlfY+
   Q: 483  PLQrLSLGDFASDKAG----SPVYQLYALCNHSGSVHYGHYTALCRC-QTGWHVYNDSRVSPVSENQVAS---SEGYVLFYQ 556
           **99*******99543....78*************************.777*******************...********8 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).

Protein Sequence
(Fasta)

MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD 60
ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCGGGTGT GGATGCGCAG GCGCTTTGAG AGACGGTGAA GCCGGTGGCC GGTGGCCGGG 60
CGGGACCAAC AAAGATGGCG GCGGCCCCTG CGGCGGGAGC GATCTGGGCA ACGGCTGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0008234--F:cysteine-type peptidase activity
GO:0046872--F:metal ion binding
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0003713--F:transcription coactivator activity
GO:0016578--P:histone deubiquitination
GO:0031175--P:neuron projection development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0016579--P:protein deubiquitination
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:27005

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001858	Ailuropoda melanoleuca	96.46	0.00e+00	1006.00
IUUC-Aca-004612	Anolis carolinensis	59.50	9.00e-174	603.00
IUUC-Ame-011548	Astyanax mexicanus	52.26	1.00e-103	370.00
IUUC-Bta-012626	Bos taurus	97.35	0.00e+00	989.00
IUUC-Cja-018853	Callithrix jacchus	98.94	0.00e+00	1044.00
IUUC-Cfa-021167	Canis familiaris	96.99	0.00e+00	998.00
IUUC-Cpo-021305	Cavia porcellus	95.76	0.00e+00	956.00
IUUC-Csa-023454	Chlorocebus sabaeus	99.82	0.00e+00	1054.00
IUUC-Cho-024836	Choloepus hoffmanni	95.85	6.00e-108	384.00
IUUC-Dre-028454	Danio rerio	53.67	1.00e-107	383.00
IUUC-Dno-029955	Dasypus novemcinctus	91.41	0.00e+00	642.00
IUUC-Dor-031053	Dipodomys ordii	96.64	0.00e+00	1052.00
IUUC-Ete-032416	Echinops telfairi	95.88	3.00e-144	505.00
IUUC-Eca-033817	Equus caballus	96.11	0.00e+00	1014.00
IUUC-Fca-036400	Felis catus	96.30	0.00e+00	991.00
IUUC-Gmo-038926	Gadus morhua	54.80	3.00e-104	372.00
IUUC-Gac-041331	Gasterosteus aculeatus	53.31	5.00e-107	380.00
IUUC-Ggo-045174	Gorilla gorilla	99.82	0.00e+00	1054.00
IUUC-Itr-048329	Ictidomys tridecemlineatus	96.65	0.00e+00	1014.00
IUUC-Lch-050539	Latimeria chalumnae	62.00	5.00e-105	375.00
IUUC-Loc-051808	Lepisosteus oculatus	55.80	2.00e-115	409.00
IUUC-Laf-053730	Loxodonta africana	94.89	0.00e+00	1021.00
IUUC-Mcc-055541	Macaca mulatta	99.82	0.00e+00	1054.00
IUUC-Meu-056279	Macropus eugenii	90.11	0.00e+00	966.00
IUUC-Mmr-060913	Microcebus murinus	97.52	0.00e+00	959.00
IUUC-Mdo-061807	Monodelphis domestica	90.11	0.00e+00	894.00
IUUC-Mmu-063599	Mus musculus	95.78	0.00e+00	963.00
IUUC-Mpu-066329	Mustela putorius furo	97.35	0.00e+00	999.00
IUUC-Mlu-067359	Myotis lucifugus	93.13	0.00e+00	890.00
IUUC-Nle-068975	Nomascus leucogenys	97.52	0.00e+00	1022.00
IUUC-Opr-071096	Ochotona princeps	93.63	0.00e+00	960.00
IUUC-Ocu-074228	Oryctolagus cuniculus	97.01	0.00e+00	994.00
IUUC-Ola-086684	Oryzias latipes	50.71	6.00e-102	364.00
IUUC-Oga-088007	Otolemur garnettii	79.15	0.00e+00	768.00
IUUC-Oar-090226	Ovis aries	96.79	0.00e+00	771.00
IUUC-Ptr-091522	Pan troglodytes	99.82	0.00e+00	1054.00
IUUC-Pan-091954	Papio anubis	99.47	0.00e+00	1046.00
IUUC-Psi-093216	Pelodiscus sinensis	60.96	0.00e+00	674.00
IUUC-Pfo-096257	Poecilia formosa	50.42	4.00e-102	364.00
IUUC-Pab-098691	Pongo abelii	99.65	0.00e+00	1053.00
IUUC-Pca-101133	Procavia capensis	88.85	0.00e+00	952.00
IUUC-Pva-102681	Pteropus vampyrus	93.45	0.00e+00	938.00
IUUC-Rno-105132	Rattus norvegicus	96.64	0.00e+00	990.00
IUUC-Sha-107145	Sarcophilus harrisii	89.76	0.00e+00	881.00
IUUC-Ssc-115586	Sus scrofa	97.52	0.00e+00	980.00
IUUC-Tgu-117491	Taeniopygia guttata	81.89	1.00e-113	402.00
IUUC-Tni-120746	Tetraodon nigroviridis	51.64	5.00e-96	344.00
IUUC-Tbe-127465	Tupaia belangeri	98.60	1.00e-126	446.00
IUUC-Ttr-128274	Tursiops truncatus	94.87	0.00e+00	958.00
IUUC-Xtr-131989	Xenopus tropicalis	48.80	1.00e-127	449.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence