iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-086308

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04080878

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000006140.1	ENSORLT00000007723.1	ENSORLP00000007722.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-84	282.3	4448	4782
E3 adaptor/Cullin RING/DCX/DWD	3.80e-06	27.4	3366	3397

Active Site

Position(s)	Description	Evidence
4751	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++elq+  + l+ +++n+ + +  n d++l np     +h+  F+flG+l+++a+++++
   Q: 4448 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELQSGVVDLLIRTPNSCADVGSNTDRFLLNPaahsdDHMVQFRFLGILMAVAIRTKK 4534
           556666***************************************************999999999********************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l++ +l   dleevd  +y++l+ i ++++s i+e+++++++  ++ +  +++      +pgG+ni+ t +N+ 
   Q: 4535 PLDLHLAPWVWKQLCSMPLGGPDLEEVDLLTYRTLQGIVHLENSGITEENFHVMIPLDSFVAHSADGMLvpVVPGGQNISLTFANRT 4621
           *******************************************************999988666666544489************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ ++yrl+e +++qv+a+reG++++ip  llsl+t+++le+l+cG +e++ve+lk+  +y++ +te+++ i wFwe leef++
   Q: 4622 EYVERALDYRLHE-MDSQVAAVREGMSTIIPVPLLSLLTAQQLEQLVCGLPEVSVEMLKRLVRYRD-ITESNQLIGWFWESLEEFTN 4706
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  fL+Fv+g+srlP  + a+++ ++f+i k d+  + lP+++TCf++L+LP+Yss+ il e+L+y i++++++++
   Q: 4707 EERVLFLRFVSGRSRLP-SNPADMS-QKFQIIKvDRPINGLPTAQTCFFLLRLPPYSSQAILAERLRYSIHNCTSIDM 4782
           *****************.699****.556666637777***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH ++v ++ + s+  +l+++s D ++++W++
   Q: 3366 GHYNKVASCFWsSEhSFLATCSQDSVVQLWSI 3397
           56677777758877889*************95 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MVPCQTHVLL KWQEHFNSSW ASEEGLKTAK RHGAAALYDK LLHNKELVTL AQPVQELVGP 60
RLPDFECDAS AAAEKEEYLS SLLRSQRWLA HRMLTETSYT LALHRRLVVL QRIYYAFHSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCCTT GTCAGACCCA TGTGTTGTTG AAGTGGCAGG AGCACTTCAA TAGTTCCTGG 60
GCTTCAGAGG AGGGTTTGAA GACAGCAAAG AGACACGGGG CTGCCGCTCT TTACGATAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006545	Arabidopsis lyrata	34.22	2.00e-47	184.00
IUUC-Ame-011268	Astyanax mexicanus	71.13	0.00e+00	2561.00
IUUC-Gac-042444	Gasterosteus aculeatus	75.57	0.00e+00	6878.00
IUUC-Loc-052805	Lepisosteus oculatus	62.31	0.00e+00	5296.00
IUUC-Pfo-096464	Poecilia formosa	77.09	0.00e+00	6848.00
IUUC-Pop-099121	Populus trichocarpa	33.15	8.00e-51	195.00
IUUC-Tru-118723	Takifugu rubripes	73.88	0.00e+00	6598.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence