iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000120868.13	ENST00000551964.5	ENSP00000448165.1
ENSG00000120868.13	ENST00000359972.6	ENSP00000353059.2
ENSG00000120868.13	ENST00000547743.1	ENSP00000450175.1
ENSG00000120868.13	ENST00000552268.5	ENSP00000448826.1
ENSG00000120868.13	ENST00000550527.5	ENSP00000448449.1
ENSG00000120868.13	ENST00000547045.5	ENSP00000449791.1
ENSG00000120868.13	ENST00000549007.1	ENSP00000448161.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-59	196.5	741	775
UBD/Beta-Prp	1.20e-86	292.3	614	774

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD ++ 
   Q: 741  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDATSA 775
           8***********777****************8776 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsl 100
           h++ ++  +fs+d++ +a+ ++d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vht+ +h+++v ++
   Q: 614  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCC 705
           55556667777777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 101  sfspsg..dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlkt 168
           +f  s+    l++Gs+d  +++wdl++++c + t  gh+ +vn+ +++pd++ll+s+s+D+t++lWd  +
   Q: 706  HFTNSShhLLLATGSSDCFLKLWDLNQKECRN-TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 774
           77774422455677777777777777777777.7777777777777777777777777777777777643 PP

Organism

Homo sapiens

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 60
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCTACGC GCGCGGGCAT GAGCCGTGGC AGGAGTGCGC GGCGGCAGCG GTGGCCGCCC 60
CTTGGGGCTT GGGGTGTGTT TATTTGCATA AGCGGGCGCG CGCCGTCCGG GCTGGGTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0005634--C:nucleus
GO:0034774--C:secretory granule lumen
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000166--F:nucleotide binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568--P:aging
GO:0006915--P:apoptotic process
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0030154--P:cell differentiation
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0030900--P:forebrain development
GO:0034349--P:glial cell apoptotic process
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007399--P:nervous system development
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:0043312--P:neutrophil degranulation
GO:0043065--P:positive regulation of apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0051260--P:protein homooligomerization
GO:1902510--P:regulation of apoptotic DNA fragmentation
GO:0042981--P:regulation of apoptotic process
GO:0072432--P:response to G1 DNA damage checkpoint signaling
GO:0001666--P:response to hypoxia
GO:0007584--P:response to nutrient

KEGG

hsa:317

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	91.13	0.00e+00	2311.00
IUUC-Apl-004201	Anas platyrhynchos	70.90	0.00e+00	1831.00
IUUC-Aca-004638	Anolis carolinensis	68.95	0.00e+00	1813.00
IUUC-Ani-009285	Aspergillus nidulans	25.75	8.00e-67	249.00
IUUC-Ame-011062	Astyanax mexicanus	54.91	0.00e+00	1376.00
IUUC-Bta-012865	Bos taurus	90.47	0.00e+00	2331.00
IUUC-Cja-018815	Callithrix jacchus	84.74	0.00e+00	2132.00
IUUC-Cfa-020222	Canis familiaris	86.69	0.00e+00	2176.00
IUUC-Cpo-021524	Cavia porcellus	88.23	0.00e+00	2273.00
IUUC-Csa-023861	Chlorocebus sabaeus	97.28	0.00e+00	2494.00
IUUC-Cho-024484	Choloepus hoffmanni	79.34	0.00e+00	1209.00
IUUC-Dre-028006	Danio rerio	53.35	0.00e+00	1268.00
IUUC-Dno-029591	Dasypus novemcinctus	90.31	0.00e+00	2332.00
IUUC-Dor-030237	Dipodomys ordii	75.67	0.00e+00	1086.00
IUUC-Ete-032620	Echinops telfairi	85.16	0.00e+00	1090.00
IUUC-Eca-033569	Equus caballus	90.39	0.00e+00	2312.00
IUUC-Eeu-035354	Erinaceus europaeus	64.17	7.00e-176	611.00
IUUC-Fca-036337	Felis catus	91.20	0.00e+00	2345.00
IUUC-Fal-037077	Ficedula albicollis	70.94	0.00e+00	1826.00
IUUC-Gmo-039687	Gadus morhua	51.01	0.00e+00	938.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.78	3.00e-41	164.00
IUUC-Gga-040299	Gallus gallus	69.70	0.00e+00	1843.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.08	0.00e+00	1281.00
IUUC-Ggo-045563	Gorilla gorilla	99.44	0.00e+00	2554.00
IUUC-Lch-050200	Latimeria chalumnae	65.25	0.00e+00	1637.00
IUUC-Loc-052090	Lepisosteus oculatus	59.40	0.00e+00	1514.00
IUUC-Laf-053861	Loxodonta africana	90.87	0.00e+00	2331.00
IUUC-Mcc-055543	Macaca mulatta	97.68	0.00e+00	2503.00
IUUC-Meu-056688	Macropus eugenii	80.35	0.00e+00	2047.00
IUUC-Mga-059243	Meleagris gallopavo	70.39	0.00e+00	1855.00
IUUC-Mmr-061134	Microcebus murinus	86.54	0.00e+00	2023.00
IUUC-Mdo-062913	Monodelphis domestica	79.07	0.00e+00	2056.00
IUUC-Mmu-063811	Mus musculus	87.35	0.00e+00	2275.00
IUUC-Mpu-066780	Mustela putorius furo	91.04	0.00e+00	2310.00
IUUC-Mlu-067276	Myotis lucifugus	90.08	0.00e+00	2315.00
IUUC-Nle-069129	Nomascus leucogenys	98.08	0.00e+00	2508.00
IUUC-Opr-071007	Ochotona princeps	67.14	0.00e+00	1122.00
IUUC-Ont-071348	Oreochromis niloticus	55.41	0.00e+00	1412.00
IUUC-Oan-072717	Ornithorhynchus anatinus	81.22	0.00e+00	2113.00
IUUC-Ocu-074286	Oryctolagus cuniculus	90.98	0.00e+00	1992.00
IUUC-Ola-086895	Oryzias latipes	50.58	0.00e+00	1196.00
IUUC-Oga-088678	Otolemur garnettii	91.11	0.00e+00	2344.00
IUUC-Oar-089359	Ovis aries	90.15	0.00e+00	2328.00
IUUC-Ptr-091062	Pan troglodytes	99.44	0.00e+00	2554.00
IUUC-Pan-092528	Papio anubis	98.76	0.00e+00	1459.00
IUUC-Psi-093430	Pelodiscus sinensis	73.76	0.00e+00	1918.00
IUUC-Pma-094690	Petromyzon marinus	38.74	1.00e-151	530.00
IUUC-Pfo-097204	Poecilia formosa	54.80	0.00e+00	1385.00
IUUC-Pab-097690	Pongo abelii	99.04	0.00e+00	2540.00
IUUC-Pca-100778	Procavia capensis	70.93	0.00e+00	1183.00
IUUC-Pva-102870	Pteropus vampyrus	88.24	0.00e+00	2101.00
IUUC-Rno-104889	Rattus norvegicus	87.35	0.00e+00	2240.00
IUUC-Sha-107465	Sarcophilus harrisii	79.04	0.00e+00	2088.00
IUUC-Sar-113268	Sorex araneus	91.17	0.00e+00	676.00
IUUC-Ssc-115654	Sus scrofa	89.75	0.00e+00	2316.00
IUUC-Tgu-117302	Taeniopygia guttata	70.94	0.00e+00	1837.00
IUUC-Tru-118363	Takifugu rubripes	54.69	0.00e+00	1388.00
IUUC-Tsy-119007	Tarsius syrichta	88.14	0.00e+00	2242.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.12	0.00e+00	1337.00
IUUC-Tbe-127413	Tupaia belangeri	77.45	0.00e+00	1409.00
IUUC-Ttr-129213	Tursiops truncatus	84.70	0.00e+00	2133.00
IUUC-Vpa-130146	Vicugna pacos	85.16	0.00e+00	1619.00
IUUC-Xtr-132559	Xenopus tropicalis	61.34	0.00e+00	1548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence