iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021674

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02009844

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000005897.3	ENSCPOT00000005960.2	ENSCPOP00000005319.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-16	59.4	1882	1912
E3 activity/HECT	2.80e-93	312.9	2962	3297

Active Site

Position(s)	Description	Evidence
3266	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 1882 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 1912
           55416677.*9778****************97 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 2962 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 3048
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 3049 PLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 3135
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e  ++qv+a+reG+++++p  llsl+t ++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 3136 EYVERAIEYRLHEMDRQQVAAVREGMSWIVPVPLLSLLTSKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWRTLEEFSN 3221
           ****************************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 3222 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 3297
           *****************6.899999.679999956666***********************************99987 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

GLMHSQLESL SDSWVHLKHS RDWLYNSSYS FESDFDLTKS LGVHTLIENV GSFVSGDVGN 60
TPGFKEPEDS MSTSPQASII AMEQQQLRAE LRLEALHQIL VLLSGMEEKG SLSLAGSRLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCTTATGC ATAGTCAGTT GGAATCCCTG AGTGACTCTT GGGTCCACCT GAAACATAGC 60
AGAGACTGGT TATACAACTC CTCTTACTCT TTTGAGTCTG ATTTTGATCT CACCAAGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	96.68	0.00e+00	5955.00
IUUC-Atr-003065	Amborella trichopoda	32.99	6.00e-48	186.00
IUUC-Apl-003461	Anas platyrhynchos	91.88	0.00e+00	5694.00
IUUC-Aca-004452	Anolis carolinensis	83.51	0.00e+00	4913.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	3.00e-48	187.00
IUUC-Ame-011268	Astyanax mexicanus	60.70	0.00e+00	2226.00
IUUC-Bta-013213	Bos taurus	96.47	0.00e+00	5918.00
IUUC-Bdi-014791	Brachypodium distachyon	35.28	5.00e-53	201.00
IUUC-Bol-015203	Brassica oleracea	35.07	6.00e-50	192.00
IUUC-Bra-017584	Brassica rapa	34.46	1.00e-49	192.00
IUUC-Cja-019298	Callithrix jacchus	96.53	0.00e+00	5947.00
IUUC-Cfa-021213	Canis familiaris	96.87	0.00e+00	6008.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.76	2.00e-50	193.00
IUUC-Csa-023341	Chlorocebus sabaeus	96.29	0.00e+00	5922.00
IUUC-Cho-024567	Choloepus hoffmanni	94.24	0.00e+00	1768.00
IUUC-Dre-028289	Danio rerio	77.64	0.00e+00	4811.00
IUUC-Dno-029988	Dasypus novemcinctus	95.51	0.00e+00	5908.00
IUUC-Dor-030636	Dipodomys ordii	94.44	0.00e+00	2137.00
IUUC-Ete-032598	Echinops telfairi	84.95	0.00e+00	1366.00
IUUC-Eca-033754	Equus caballus	96.66	0.00e+00	5957.00
IUUC-Eeu-034702	Erinaceus europaeus	90.85	0.00e+00	1487.00
IUUC-Fca-035900	Felis catus	96.87	0.00e+00	5980.00
IUUC-Fal-037034	Ficedula albicollis	88.38	0.00e+00	4584.00
IUUC-Gmo-039260	Gadus morhua	75.03	0.00e+00	1258.00
IUUC-Gga-040321	Gallus gallus	92.03	0.00e+00	5752.00
IUUC-Gac-042444	Gasterosteus aculeatus	57.33	0.00e+00	2222.00
IUUC-Ggo-045134	Gorilla gorilla	96.51	0.00e+00	3431.00
IUUC-Hsa-046516	Homo sapiens	96.29	0.00e+00	5916.00
IUUC-Hvu-047529	Hordeum vulgare	35.38	2.00e-48	187.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	97.37	0.00e+00	2551.00
IUUC-Lch-049903	Latimeria chalumnae	85.93	0.00e+00	5340.00
IUUC-Lpe-051165	Leersia perrieri	34.08	4.00e-51	195.00
IUUC-Loc-052149	Lepisosteus oculatus	82.75	0.00e+00	5018.00
IUUC-Laf-053426	Loxodonta africana	96.20	0.00e+00	5938.00
IUUC-Mcc-055826	Macaca mulatta	96.62	0.00e+00	5968.00
IUUC-Meu-056521	Macropus eugenii	89.07	0.00e+00	2101.00
IUUC-Mga-059964	Meleagris gallopavo	82.68	0.00e+00	845.00
IUUC-Mmr-061512	Microcebus murinus	96.87	0.00e+00	5939.00
IUUC-Mdo-062177	Monodelphis domestica	92.84	0.00e+00	5670.00
IUUC-Mmu-064373	Mus musculus	96.29	0.00e+00	5917.00
IUUC-Mpu-066148	Mustela putorius furo	96.05	0.00e+00	5901.00
IUUC-Mlu-067680	Myotis lucifugus	95.72	0.00e+00	5900.00
IUUC-Nle-069633	Nomascus leucogenys	96.23	0.00e+00	5860.00
IUUC-Opr-070609	Ochotona princeps	95.70	0.00e+00	1445.00
IUUC-Ont-071249	Oreochromis niloticus	79.88	0.00e+00	5032.00
IUUC-Oan-073157	Ornithorhynchus anatinus	92.09	0.00e+00	5616.00
IUUC-Ocu-074841	Oryctolagus cuniculus	95.93	0.00e+00	5982.00
IUUC-Oba-075262	Oryza barthii	34.16	2.00e-49	190.00
IUUC-Obr-076115	Oryza brachyantha	34.61	3.00e-49	189.00
IUUC-Ogl-077586	Oryza glaberrima	34.16	1.00e-49	190.00
IUUC-Ogu-078796	Oryza glumaepatula	33.92	6.00e-49	188.00
IUUC-Oin-079298	Oryza indica	33.92	7.00e-49	187.00
IUUC-Olo-080768	Oryza longistaminata	35.36	5.00e-54	204.00
IUUC-Ome-081908	Oryza meridionalis	33.42	3.00e-48	186.00
IUUC-Oni-082049	Oryza nivara	33.92	6.00e-49	188.00
IUUC-Opu-083608	Oryza punctata	33.67	3.00e-50	192.00
IUUC-Oru-084712	Oryza rufipogon	33.92	6.00e-49	188.00
IUUC-Osa-086078	Oryza sativa	33.92	6.00e-49	188.00
IUUC-Ola-086889	Oryzias latipes	78.89	0.00e+00	4998.00
IUUC-Oga-088459	Otolemur garnettii	97.02	0.00e+00	5922.00
IUUC-Oar-089888	Ovis aries	96.44	0.00e+00	5886.00
IUUC-Ptr-091114	Pan troglodytes	96.62	0.00e+00	5940.00
IUUC-Pan-092442	Papio anubis	96.44	0.00e+00	5943.00
IUUC-Psi-093833	Pelodiscus sinensis	91.97	0.00e+00	5469.00
IUUC-Pma-094275	Petromyzon marinus	47.70	2.00e-85	311.00
IUUC-Ppa-095790	Physcomitrella patens	36.17	1.00e-54	206.00
IUUC-Pfo-097262	Poecilia formosa	79.28	0.00e+00	4917.00
IUUC-Pab-097760	Pongo abelii	96.70	0.00e+00	4940.00
IUUC-Pop-099121	Populus trichocarpa	36.63	8.00e-52	199.00
IUUC-Pca-100465	Procavia capensis	96.01	0.00e+00	4580.00
IUUC-Ppe-101345	Prunus persica	34.02	6.00e-52	199.00
IUUC-Pva-102950	Pteropus vampyrus	96.82	0.00e+00	3089.00
IUUC-Rno-104892	Rattus norvegicus	96.02	0.00e+00	5847.00
IUUC-Sha-106633	Sarcophilus harrisii	92.69	0.00e+00	5569.00
IUUC-Smo-108827	Selaginella moellendorffii	35.14	3.00e-51	197.00
IUUC-Sit-110415	Setaria italica	34.96	1.00e-53	203.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	4.00e-53	202.00
IUUC-Stu-112166	Solanum tuberosum	31.97	5.00e-49	189.00
IUUC-Sar-113251	Sorex araneus	87.52	0.00e+00	2232.00
IUUC-Ssc-116391	Sus scrofa	96.17	0.00e+00	5938.00
IUUC-Tgu-116554	Taeniopygia guttata	91.19	0.00e+00	5717.00
IUUC-Tru-118695	Takifugu rubripes	79.28	0.00e+00	5031.00
IUUC-Tsy-119647	Tarsius syrichta	91.36	0.00e+00	4520.00
IUUC-Tni-120707	Tetraodon nigroviridis	79.08	0.00e+00	4965.00
IUUC-Tca-121094	Theobroma cacao	35.07	4.00e-51	196.00
IUUC-Tae-124157	Triticum aestivum	31.82	6.00e-45	176.00
IUUC-Tur-126300	Triticum urartu	35.38	6.00e-49	189.00
IUUC-Tbe-127346	Tupaia belangeri	89.73	0.00e+00	2590.00
IUUC-Ttr-128542	Tursiops truncatus	93.34	0.00e+00	4794.00
IUUC-Vpa-130611	Vicugna pacos	95.51	0.00e+00	2777.00
IUUC-Xtr-131933	Xenopus tropicalis	84.30	0.00e+00	5121.00
IUUC-Xma-134216	Xiphophorus maculatus	75.96	0.00e+00	4710.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence