iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024170

Ensembl Protein ID

ENSCSAP00000010095.1

UniProt Accession

A0A0D9RNA6; A0A0D9RNA6_CHLSB

Genbank Protein ID

ENSCSAP00000010095

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AQIB01140747

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000013953.1	ENSCSAT00000012045.1	ENSCSAP00000010095.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-12	46.4	792	849

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           +k  v++l+dy+aq +deLt++k  +++ +  e+q++gW++g  +  gk+ l fP+n+ve++
   Q: 792  FKCAVKALFDYKAQREDELTFTKSAIIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEM 849
           56789************************9..9*********..676666655******985 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 60
TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGGGGC CTCAGGGCCG CCCCGCCCCG CCGCGCTCAG GCCCCGCCCC GTGTCCGCCT 60
GCAGGAGCCG CCGCCGGGTC CCGCTCGTCG GCCGTCTCAG CCTCAGCCCC AGCCTCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00388--PI-PLC-X
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00148--PLCXc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001701--P:in utero embryonic development
GO:0016042--P:lipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	97.24	0.00e+00	1888.00
IUUC-Apl-003541	Anas platyrhynchos	69.57	0.00e+00	1279.00
IUUC-Aca-005291	Anolis carolinensis	87.69	0.00e+00	1638.00
IUUC-Ame-011004	Astyanax mexicanus	69.08	0.00e+00	1283.00
IUUC-Bta-012660	Bos taurus	97.80	0.00e+00	1753.00
IUUC-Cja-019206	Callithrix jacchus	98.29	0.00e+00	1889.00
IUUC-Cfa-020257	Canis familiaris	97.92	0.00e+00	1753.00
IUUC-Cpo-022391	Cavia porcellus	89.77	0.00e+00	1708.00
IUUC-Dre-027944	Danio rerio	73.35	0.00e+00	1372.00
IUUC-Dno-029440	Dasypus novemcinctus	97.34	0.00e+00	1654.00
IUUC-Dor-031001	Dipodomys ordii	96.37	0.00e+00	1872.00
IUUC-Eca-033809	Equus caballus	97.92	0.00e+00	1754.00
IUUC-Fca-036510	Felis catus	97.34	0.00e+00	1744.00
IUUC-Fal-037541	Ficedula albicollis	89.58	0.00e+00	1502.00
IUUC-Gmo-038630	Gadus morhua	62.83	0.00e+00	1122.00
IUUC-Gga-040142	Gallus gallus	90.26	0.00e+00	1694.00
IUUC-Ggo-045063	Gorilla gorilla	99.68	0.00e+00	1930.00
IUUC-Hsa-046428	Homo sapiens	99.57	0.00e+00	1928.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	97.45	0.00e+00	1825.00
IUUC-Lch-049766	Latimeria chalumnae	81.16	0.00e+00	1415.00
IUUC-Loc-052285	Lepisosteus oculatus	77.10	0.00e+00	1485.00
IUUC-Laf-053365	Loxodonta africana	97.57	0.00e+00	1752.00
IUUC-Mcc-054871	Macaca mulatta	99.03	0.00e+00	1899.00
IUUC-Meu-056724	Macropus eugenii	88.34	0.00e+00	1548.00
IUUC-Mga-059329	Meleagris gallopavo	88.85	0.00e+00	1574.00
IUUC-Mmr-061110	Microcebus murinus	97.65	0.00e+00	1886.00
IUUC-Mdo-062448	Monodelphis domestica	94.66	0.00e+00	1845.00
IUUC-Mmu-063565	Mus musculus	96.91	0.00e+00	1886.00
IUUC-Mpu-066683	Mustela putorius furo	97.97	0.00e+00	1903.00
IUUC-Mlu-067779	Myotis lucifugus	96.42	0.00e+00	1724.00
IUUC-Nle-069219	Nomascus leucogenys	98.84	0.00e+00	1758.00
IUUC-Opr-070766	Ochotona princeps	91.75	0.00e+00	759.00
IUUC-Ont-072524	Oreochromis niloticus	76.36	0.00e+00	1472.00
IUUC-Oan-073214	Ornithorhynchus anatinus	92.39	8.00e-47	179.00
IUUC-Ocu-074361	Oryctolagus cuniculus	94.14	0.00e+00	1810.00
IUUC-Ola-086820	Oryzias latipes	75.03	0.00e+00	1457.00
IUUC-Oga-088172	Otolemur garnettii	98.19	0.00e+00	1904.00
IUUC-Oar-090306	Ovis aries	95.03	0.00e+00	1691.00
IUUC-Ptr-090682	Pan troglodytes	99.68	0.00e+00	1930.00
IUUC-Pan-092835	Papio anubis	99.82	0.00e+00	1150.00
IUUC-Psi-093344	Pelodiscus sinensis	88.00	0.00e+00	1694.00
IUUC-Pfo-096984	Poecilia formosa	73.99	0.00e+00	1426.00
IUUC-Pab-097871	Pongo abelii	99.67	0.00e+00	1857.00
IUUC-Pca-100772	Procavia capensis	92.32	0.00e+00	1768.00
IUUC-Pva-102790	Pteropus vampyrus	97.97	0.00e+00	1893.00
IUUC-Rno-105974	Rattus norvegicus	96.80	0.00e+00	1884.00
IUUC-Sar-112995	Sorex araneus	94.73	0.00e+00	1768.00
IUUC-Ssc-115360	Sus scrofa	98.18	0.00e+00	1894.00
IUUC-Tgu-116585	Taeniopygia guttata	86.27	0.00e+00	1587.00
IUUC-Tru-117742	Takifugu rubripes	76.89	0.00e+00	1481.00
IUUC-Tsy-119259	Tarsius syrichta	97.73	6.00e-154	538.00
IUUC-Tni-120553	Tetraodon nigroviridis	77.59	0.00e+00	1424.00
IUUC-Tbe-127504	Tupaia belangeri	80.42	0.00e+00	1105.00
IUUC-Ttr-128650	Tursiops truncatus	97.15	0.00e+00	1330.00
IUUC-Xtr-132862	Xenopus tropicalis	78.43	0.00e+00	1480.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence