iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046483

Ensembl Protein ID

ENSP00000309714.5

UniProt Accession

A1X283; B6F0V2; Q9P2Q1; SPD2B_HUMAN

Genbank Protein ID

BAG81977.1; AAZ99795.1; BAA92533.1

Protein Name

SH3 and PX domain-containing protein 2B; Adapter protein HOFI; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains

Genbank Nucleotide ID

AB430862; DQ109556; AC008671

Gene Name

SH3PXD2B; FAD49; KIAA1295; TKS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000174705.12	ENST00000636523.1	ENSP00000490082.1
ENSG00000174705.12	ENST00000519643.5	ENSP00000430890.1
ENSG00000174705.12	ENST00000518522.5	ENSP00000428076.1
ENSG00000174705.12	ENST00000311601.5	ENSP00000309714.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.20e-24	84.8	223	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +ek  v+y+y+a ++de++l++G vv+vi  +++ egW+k     +gk+G  P+ + +k
   Q: 223  EEKYTVIYPYTARDQDEMNLERGAVVEVI--QKNLEGWWKI--RYQGKEGWAPASYLKK 277
           67889************************..8899****88..9**********99886 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).

Protein Sequence
(Fasta)

MPPRRSIVEV KVLDVQKRRV PNKHYVYIIR VTWSSGSTEA IYRRYSKFFD LQMQMLDKFP 60
MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE YCKALIQLPP YISQCDEVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCGCGCC GAGCGAAGGG CGGCGGCGGT GGCGGCGGCG GCTCGTGCTC GGCCCCGGCT 60
GCGATTGCGC TCAGCTCCAG GTTCCCTGCC CGCGGCGGCG CGCCCCCAGC GCTCCCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR001683--Phox
IPR011511--SH3_2
IPR001452--SH3_domain
IPR030512--SH3PXD2B

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF00787--PX
PF00018--SH3_1
PF07653--SH3_2

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0002102--C:podosome
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0070273--F:phosphatidylinositol-4-phosphate binding
GO:0010314--F:phosphatidylinositol-5-phosphate binding
GO:0042169--F:SH2 domain binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0060612--P:adipose tissue development
GO:0060348--P:bone development
GO:1904888--P:cranial skeletal system development
GO:0022617--P:extracellular matrix disassembly
GO:0001654--P:eye development
GO:0007507--P:heart development
GO:0002051--P:osteoblast fate commitment
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:1904179--P:positive regulation of adipose tissue development
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0040018--P:positive regulation of multicellular organism growth
GO:0051496--P:positive regulation of stress fiber assembly
GO:0072657--P:protein localization to membrane
GO:0060378--P:regulation of brood size
GO:0001501--P:skeletal system development
GO:0048705--P:skeletal system morphogenesis
GO:0006801--P:superoxide metabolic process

KEGG

hsa:285590

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001572	Ailuropoda melanoleuca	89.39	0.00e+00	1540.00
IUUC-Apl-003349	Anas platyrhynchos	66.63	0.00e+00	1058.00
IUUC-Aca-004769	Anolis carolinensis	66.38	0.00e+00	1073.00
IUUC-Ame-011734	Astyanax mexicanus	50.00	3.00e-135	476.00
IUUC-Bta-012847	Bos taurus	86.79	0.00e+00	1462.00
IUUC-Bci-013600	Botrytis cinerea	33.59	9.00e-15	75.50
IUUC-Cja-019338	Callithrix jacchus	92.76	0.00e+00	1593.00
IUUC-Cfa-020751	Canis familiaris	88.55	0.00e+00	1506.00
IUUC-Cpo-021623	Cavia porcellus	87.25	0.00e+00	1456.00
IUUC-Csa-023399	Chlorocebus sabaeus	97.48	0.00e+00	1647.00
IUUC-Cho-024720	Choloepus hoffmanni	85.83	1.00e-108	387.00
IUUC-Cin-025592	Ciona intestinalis	38.44	7.00e-89	321.00
IUUC-Csv-026038	Ciona savignyi	38.23	1.00e-84	307.00
IUUC-Cgl-026496	Colletotrichum gloeosporioides	32.81	4.00e-14	73.60
IUUC-Cne-026892	Cryptococcus neoformans	26.40	2.00e-09	58.20
IUUC-Dno-029443	Dasypus novemcinctus	84.99	0.00e+00	1237.00
IUUC-Dor-030546	Dipodomys ordii	79.68	0.00e+00	1339.00
IUUC-Ete-032485	Echinops telfairi	74.60	0.00e+00	1156.00
IUUC-Eca-033780	Equus caballus	87.91	0.00e+00	1410.00
IUUC-Fca-036365	Felis catus	86.84	0.00e+00	1434.00
IUUC-Fal-036632	Ficedula albicollis	69.51	0.00e+00	846.00
IUUC-Fox-037760	Fusarium oxysporum	32.69	1.00e-13	71.60
IUUC-Fso-038453	Fusarium solani	33.65	1.00e-13	71.20
IUUC-Gmo-039101	Gadus morhua	69.29	3.00e-143	503.00
IUUC-Ggr-039899	Gaeumannomyces graminis	32.28	7.00e-15	75.90
IUUC-Gac-041676	Gasterosteus aculeatus	58.25	0.00e+00	666.00
IUUC-Ggo-045275	Gorilla gorilla	97.80	0.00e+00	1630.00
IUUC-Itr-048237	Ictidomys tridecemlineatus	83.69	0.00e+00	1311.00
IUUC-Kpa-049363	Komagataella pastoris	31.09	5.00e-15	76.30
IUUC-Lch-049474	Latimeria chalumnae	59.01	0.00e+00	915.00
IUUC-Loc-052659	Lepisosteus oculatus	59.03	0.00e+00	795.00
IUUC-Laf-054220	Loxodonta africana	87.81	0.00e+00	1449.00
IUUC-Mcc-055001	Macaca mulatta	95.85	0.00e+00	1610.00
IUUC-Meu-056086	Macropus eugenii	72.37	0.00e+00	1155.00
IUUC-Mor-057190	Magnaporthe oryzae	33.65	1.00e-13	72.00
IUUC-Mpo-057398	Magnaporthe poae	33.65	6.00e-14	72.40
IUUC-Mga-059772	Meleagris gallopavo	81.46	0.00e+00	795.00
IUUC-Mmr-061321	Microcebus murinus	85.55	0.00e+00	1352.00
IUUC-Mdo-061943	Monodelphis domestica	75.95	0.00e+00	1283.00
IUUC-Mmu-063247	Mus musculus	84.81	0.00e+00	1485.00
IUUC-Mpu-065848	Mustela putorius furo	86.17	0.00e+00	1548.00
IUUC-Mlu-067413	Myotis lucifugus	83.93	0.00e+00	1326.00
IUUC-Nle-069834	Nomascus leucogenys	97.22	0.00e+00	1141.00
IUUC-Opr-070355	Ochotona princeps	78.54	0.00e+00	1176.00
IUUC-Ont-072669	Oreochromis niloticus	61.43	0.00e+00	715.00
IUUC-Oan-073473	Ornithorhynchus anatinus	75.00	0.00e+00	823.00
IUUC-Ocu-073822	Oryctolagus cuniculus	82.62	0.00e+00	1372.00
IUUC-Oga-088006	Otolemur garnettii	89.25	0.00e+00	1514.00
IUUC-Oar-090176	Ovis aries	84.48	0.00e+00	1410.00
IUUC-Ptr-090730	Pan troglodytes	97.48	0.00e+00	1620.00
IUUC-Pan-092549	Papio anubis	96.58	0.00e+00	1316.00
IUUC-Pfo-096582	Poecilia formosa	56.86	0.00e+00	662.00
IUUC-Pab-097634	Pongo abelii	98.90	0.00e+00	1657.00
IUUC-Pca-101110	Procavia capensis	80.27	0.00e+00	1169.00
IUUC-Pva-103256	Pteropus vampyrus	83.39	0.00e+00	890.00
IUUC-Rno-106109	Rattus norvegicus	84.96	0.00e+00	1220.00
IUUC-Sce-106380	Saccharomyces cerevisiae	31.86	7.00e-11	62.40
IUUC-Spo-108303	Schizosaccharomyces pombe	28.44	2.00e-10	60.80
IUUC-Ssl-108480	Sclerotinia sclerotiorum	31.90	1.00e-12	68.20
IUUC-Sre-114971	Sporisorium reilianum	34.04	2.00e-10	61.20
IUUC-Ssc-115251	Sus scrofa	86.39	0.00e+00	1369.00
IUUC-Tgu-116480	Taeniopygia guttata	65.78	0.00e+00	940.00
IUUC-Tru-117751	Takifugu rubripes	66.53	1.00e-173	603.00
IUUC-Tni-120253	Tetraodon nigroviridis	55.25	2.00e-174	606.00
IUUC-Tre-121970	Trichoderma reesei	35.24	2.00e-14	73.90
IUUC-Tvi-122571	Trichoderma virens	34.29	8.00e-14	72.40
IUUC-Tme-127033	Tuber melanosporum	33.03	3.00e-13	70.50
IUUC-Tbe-127871	Tupaia belangeri	80.13	0.00e+00	1018.00
IUUC-Ttr-128955	Tursiops truncatus	88.93	0.00e+00	1517.00
IUUC-Uma-129402	Ustilago maydis	34.04	2.00e-10	61.20
IUUC-Vda-129885	Verticillium dahliae	32.81	5.00e-14	72.80
IUUC-Xtr-132258	Xenopus tropicalis	58.82	0.00e+00	901.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence