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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064061
Ensembl Protein ID ENSMUSP00000075658.4
UniProt Accession Q6Y5D8; Q6Y5D6; Q6Y5D7; Q99MT3; Q99MT4; RHG10_MOUSE
Genbank Protein ID AAK18174.1; AAK18175.1; AAO62072.1; AAO62073.1; AAO62074.1
Protein Name Rho GTPase-activating protein 10; PH and SH3 domain-containing rhoGAP protein; Rho-type GTPase-activating protein 10
Genbank Nucleotide ID AF297029; AF297030; AY179965; AY179966; AY179967
Gene Name Arhgap10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000037148.8 ENSMUST00000076316.5 ENSMUSP00000075658.4
ENSMUSG00000037148.8 ENSMUST00000210922.1 ENSMUSP00000147485.1
ENSMUSG00000037148.8 ENSMUST00000210519.1 ENSMUSP00000147493.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.80e-11 43.1 731 785
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +k ++ y+ ea+++ eL+++ G + + + +++ + gWl+g  +l+gkrGl+P+n+v+ 
   Q: 731  RKARAVYPCEAEHSSELSFEIGAIFEDV-QTSREPGWLEG--TLNGKRGLIPQNYVKL 785
           57789***********************.***********..8*************85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
 GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
Protein Sequence
(Fasta)
MGLQPLEFSD CYLDSPWFRE RIRAHEAELE RTNKFIKELI KDGKNLISAT KSLSAAQRKF 60
AHSLRDFKFE FIGDAETDDE RCIDASLREF SNFLKNLEEQ REIMALSVTE TLIKPLEKFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064061|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCTGCCGGG GGCTGCCGGG ATTGGGGAGC TGCGCCGCGT ACTCTCCAGG GTCGCTGGGC 60
TGGGCTGGAC ATGACCGTGC TGCGCTCGCC GCGCGCTCAG CCCTGCTAGC CGCTCGCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064061|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain
PROSITE

PS50003--PH_DOMAIN
PS50238--RHOGAP
PS50002--SH3
Pfam

PF00169--PH
PF00620--RhoGAP
PF14604--SH3_9
SMART

SM00233--PH
SM00324--RhoGAP
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0007010--P:cytoskeleton organization
GO:0043066--P:negative regulation of apoptotic process
GO:0007165--P:signal transduction
KEGG mmu:78514
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001253 Ailuropoda melanoleuca 90.84 0.00e+00 1435.00
IUUC-Apl-003297 Anas platyrhynchos 76.49 0.00e+00 1187.00
IUUC-Aca-005285 Anolis carolinensis 76.21 0.00e+00 1221.00
IUUC-Bta-012379 Bos taurus 89.19 0.00e+00 1340.00
IUUC-Cja-019182 Callithrix jacchus 90.46 0.00e+00 1423.00
IUUC-Cfa-021141 Canis familiaris 90.59 0.00e+00 1420.00
IUUC-Csa-023847 Chlorocebus sabaeus 91.01 0.00e+00 1311.00
IUUC-Cin-025725 Ciona intestinalis 40.20 9.00e-150 524.00
IUUC-Dre-027525 Danio rerio 59.57 0.00e+00 869.00
IUUC-Dno-029215 Dasypus novemcinctus 84.59 0.00e+00 914.00
IUUC-Dor-030308 Dipodomys ordii 82.56 0.00e+00 1157.00
IUUC-Ete-032666 Echinops telfairi 77.36 0.00e+00 753.00
IUUC-Eca-033545 Equus caballus 91.28 0.00e+00 1313.00
IUUC-Fca-036457 Felis catus 90.97 0.00e+00 1434.00
IUUC-Fal-036703 Ficedula albicollis 79.16 0.00e+00 1242.00
IUUC-Gga-040830 Gallus gallus 78.40 0.00e+00 1238.00
IUUC-Gac-041728 Gasterosteus aculeatus 57.11 0.00e+00 843.00
IUUC-Ggo-044569 Gorilla gorilla 88.69 0.00e+00 1263.00
IUUC-Hsa-045658 Homo sapiens 91.48 0.00e+00 1381.00
IUUC-Loc-051740 Lepisosteus oculatus 63.92 0.00e+00 978.00
IUUC-Laf-053641 Loxodonta africana 90.20 0.00e+00 1363.00
IUUC-Mcc-055152 Macaca mulatta 91.22 0.00e+00 1440.00
IUUC-Mmr-061434 Microcebus murinus 91.69 0.00e+00 1332.00
IUUC-Mdo-062864 Monodelphis domestica 84.48 0.00e+00 1340.00
IUUC-Mlu-067375 Myotis lucifugus 89.51 0.00e+00 1290.00
IUUC-Nle-069319 Nomascus leucogenys 86.88 0.00e+00 713.00
IUUC-Ont-071443 Oreochromis niloticus 58.43 0.00e+00 894.00
IUUC-Oan-072978 Ornithorhynchus anatinus 82.15 0.00e+00 1102.00
IUUC-Ocu-074591 Oryctolagus cuniculus 85.91 0.00e+00 1253.00
IUUC-Ola-087508 Oryzias latipes 63.34 0.00e+00 763.00
IUUC-Oga-088922 Otolemur garnettii 87.27 0.00e+00 635.00
IUUC-Oar-089531 Ovis aries 89.57 0.00e+00 1362.00
IUUC-Ptr-091149 Pan troglodytes 90.33 0.00e+00 1375.00
IUUC-Pan-092591 Papio anubis 91.48 0.00e+00 1438.00
IUUC-Pma-094731 Petromyzon marinus 32.35 2.00e-19 92.40
IUUC-Pfo-097265 Poecilia formosa 58.22 0.00e+00 876.00
IUUC-Pab-097780 Pongo abelii 91.09 0.00e+00 1378.00
IUUC-Rno-104991 Rattus norvegicus 98.47 0.00e+00 1545.00
IUUC-Sha-107629 Sarcophilus harrisii 80.44 0.00e+00 1080.00
IUUC-Ssc-115511 Sus scrofa 75.35 0.00e+00 705.00
IUUC-Tgu-117458 Taeniopygia guttata 78.40 0.00e+00 1227.00
IUUC-Tru-117724 Takifugu rubripes 62.50 0.00e+00 762.00
IUUC-Tbe-128126 Tupaia belangeri 25.56 1.00e-05 45.40
IUUC-Ttr-129045 Tursiops truncatus 87.19 0.00e+00 1223.00
IUUC-Xtr-132112 Xenopus tropicalis 69.97 0.00e+00 1087.00
Created Date 25-Jun-2017

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