iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-116004

Ensembl Protein ID

ENSSSCP00000024749.1

UniProt Accession

E7CR04; E7CR04_PIG

Genbank Protein ID

ADU03229.1

Protein Name

Suppressor of cytokine signaling 1

Genbank Nucleotide ID

FP476016

Gene Name

SOCS1; socs1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000027855.1	ENSSSCT00000029636.1	ENSSSCP00000024749.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.10e-13	50.2	172	219

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 172  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 219
           6789*************************...***************9986 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MVAHNQVAAD NAISTAAEPR RRPEHSSSSS SSSSSSSSSS SPGVPARPRP CPAAPAPAPG 60
DTHFRTFRSH ADYRRITRAS ALLDACGFYW GPLSVHGAHE RLRAEPVGTF LVRDSRQRNC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCGCACCC CCGGACGCTA TGGCCCACCC CTCCGGCCGA CCCCGCGTGT AGGATGGTAG 60
CACACAACCA GGTGGCAGCC GACAATGCAA TCTCCACGGC AGCAGAGCCC CGACGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

ssc:100307052

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.88	1.00e-79	288.00
IUUC-Apl-003313	Anas platyrhynchos	60.00	9.00e-75	272.00
IUUC-Aca-005109	Anolis carolinensis	68.35	4.00e-63	233.00
IUUC-Ame-011550	Astyanax mexicanus	50.00	7.00e-49	186.00
IUUC-Bta-013411	Bos taurus	89.69	9.00e-94	335.00
IUUC-Cja-019595	Callithrix jacchus	90.00	2.00e-94	337.00
IUUC-Cfa-020563	Canis familiaris	97.52	4.00e-90	323.00
IUUC-Cpo-021374	Cavia porcellus	86.82	8.00e-95	338.00
IUUC-Csa-023333	Chlorocebus sabaeus	87.27	4.00e-94	337.00
IUUC-Dre-028507	Danio rerio	46.79	2.00e-44	171.00
IUUC-Dno-029406	Dasypus novemcinctus	87.27	4.00e-93	333.00
IUUC-Ete-032399	Echinops telfairi	86.36	4.00e-92	330.00
IUUC-Eca-033519	Equus caballus	81.82	4.00e-89	320.00
IUUC-Fal-036726	Ficedula albicollis	58.64	9.00e-74	268.00
IUUC-Gmo-039667	Gadus morhua	50.44	1.00e-26	112.00
IUUC-Gga-040970	Gallus gallus	60.45	1.00e-74	271.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.00	1.00e-35	142.00
IUUC-Ggo-045569	Gorilla gorilla	81.82	3.00e-95	340.00
IUUC-Hsa-046010	Homo sapiens	90.91	2.00e-93	334.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	100.00	3.00e-93	333.00
IUUC-Lch-050219	Latimeria chalumnae	62.26	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	7.00e-55	206.00
IUUC-Laf-054219	Loxodonta africana	96.32	4.00e-72	262.00
IUUC-Mcc-054830	Macaca mulatta	86.82	4.00e-94	336.00
IUUC-Meu-056565	Macropus eugenii	70.00	2.00e-81	294.00
IUUC-Mga-060153	Meleagris gallopavo	59.55	2.00e-72	264.00
IUUC-Mmr-061365	Microcebus murinus	89.09	6.00e-93	332.00
IUUC-Mdo-062824	Monodelphis domestica	69.09	3.00e-79	287.00
IUUC-Mmu-064120	Mus musculus	89.09	5.00e-91	326.00
IUUC-Mpu-066839	Mustela putorius furo	92.27	1.00e-94	338.00
IUUC-Mlu-067829	Myotis lucifugus	97.52	2.00e-90	324.00
IUUC-Nle-069592	Nomascus leucogenys	86.82	2.00e-89	321.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	8.00e-38	149.00
IUUC-Oan-073586	Ornithorhynchus anatinus	54.21	3.00e-26	110.00
IUUC-Ocu-073996	Oryctolagus cuniculus	98.76	2.00e-92	330.00
IUUC-Oba-075150	Oryza barthii	30.59	2.50e-02	31.60
IUUC-Ola-087158	Oryzias latipes	46.25	2.00e-39	154.00
IUUC-Oga-088076	Otolemur garnettii	85.45	4.00e-92	330.00
IUUC-Ptr-091241	Pan troglodytes	90.45	1.00e-94	338.00
IUUC-Pan-091836	Papio anubis	81.82	1.00e-94	338.00
IUUC-Psi-093628	Pelodiscus sinensis	62.27	2.00e-75	274.00
IUUC-Pfo-097501	Poecilia formosa	45.28	8.00e-37	146.00
IUUC-Pab-098170	Pongo abelii	87.27	2.00e-93	334.00
IUUC-Pop-100072	Populus trichocarpa	32.69	9.00e-03	33.90
IUUC-Pva-102796	Pteropus vampyrus	87.27	5.00e-93	333.00
IUUC-Rno-105319	Rattus norvegicus	88.18	5.00e-91	326.00
IUUC-Sha-107201	Sarcophilus harrisii	81.17	2.00e-74	270.00
IUUC-Tgu-116836	Taeniopygia guttata	60.91	5.00e-76	276.00
IUUC-Tru-118090	Takifugu rubripes	43.12	4.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.75	5.00e-32	130.00
IUUC-Vpa-130235	Vicugna pacos	88.64	2.00e-93	334.00
IUUC-Xtr-132610	Xenopus tropicalis	56.82	2.00e-67	247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence