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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046753
UUCD1 version UUC-HoS-00215
Ensembl Protein ID ENSP00000290650.4
UniProt Accession Q8IWV7; O60708; O75492; Q14D45; Q68DN9; Q8IWY6; Q96JY4; UBR1_HUMAN
Genbank Protein ID AAL32103.1; AAI13506.1; AAI13508.1; AAO14997.1; BAB55380.1; CAH18181.1; AAC39845.1; AAC23677.1
Protein Name E3 ubiquitin-protein ligase UBR1; N-recognin-1; RING-type E3 ubiquitin transferase UBR1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
Genbank Nucleotide ID AY061886; BC113505; BC113507; AF525401; AK027803; CR749326; AF061556; AH006181
Gene Name UBR1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159459.11 ENST00000290650.8 ENSP00000290650.4
ENSG00000159459.11 ENST00000546274.6 ENSP00000477932.1
ENSG00000159459.11 ENST00000569243.5 ENSP00000457573.1
ENSG00000159459.11 ENST00000564540.5 ENSP00000457879.1
ENSG00000159459.11 ENST00000569066.2 ENSP00000456327.1
ENSG00000159459.11 ENST00000569971.5 ENSP00000455759.1
ENSG00000159459.11 ENST00000563239.1 ENSP00000456502.1
ENSG00000159459.11 ENST00000569337.1 ENSP00000454962.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20537150; 20148194
E3 activity/N-recognin/UBR-box UBR 20537150; 20148194
E3 activity/N-recognin/N-domain N-domain 11526102
Classification
Family E-value Score Start End
E3 activity/N-recognin/N-domain 4.30e-40 137.4 226 302
E3 activity/RING/RING 5.40e-08 34.9 1098 1201
E3 activity/N-recognin/UBR-box 1.40e-30 107.2 97 167
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/N-recognin/N-domain
   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 226  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEV 302
           9**************************************************************************97 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledf...............kd..............................gplvlpCgHvfhadClqkw.............pgl 32
           C++C+e+                ++                              g+++++CgHv+ha C+qk+             ++l
   Q: 1098 CILCQEEQevkiennamvlsacvQKstaltqhrgkpielsgealdplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqrihVDL 1187
           88885544433333333333222002333333333333333333333333333337999******************************* PP
   S: 33   knssskefrCPlCr 46
            +++s+e +CPlC+
   Q: 1188 FDLESGEYLCPLCK 1201
           *************7 PP
   

   E3 activity/N-recognin/UBR-box
   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C++++
   Q: 97   QLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHE 167
           68*******************************************************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Protein Sequence
(Fasta)
MADEEAGGTE RMEISAELPQ TPQRLASWWD QQVDFYTAFL HHLAQLVPEI YFAEMDPDLE 60
KQEESVQMSI FTPLEWYLFG EDPDICLEKL KHSGAFQLCG RVFKSGETTY SCRDCAIDPT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046753|E3,RING;E3,UBR-box;E3,N-domain|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAGTGTCG TCCCTGTCTC TCCGACCGGC CACAGGTTTC CGCTTGCCTC TGGCCGGGGG 60
TCGGCAACTG CAGGCGTCAG TTTCCCTCAA GATGGCGGAC GAGGAGGCTG GAGGTACTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046753|E3,RING;E3,UBR-box;E3,N-domain|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02617--ClpS
PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway
KEGG hsa:197131
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001354 Ailuropoda melanoleuca 94.75 0.00e+00 3338.00
IUUC-Apl-004160 Anas platyrhynchos 78.28 0.00e+00 2748.00
IUUC-Aca-004982 Anolis carolinensis 75.43 0.00e+00 2649.00
IUUC-Acl-008055 Aspergillus clavatus 23.20 3.00e-48 188.00
IUUC-Ani-009334 Aspergillus nidulans 22.97 1.00e-49 193.00
IUUC-Ate-010550 Aspergillus terreus 22.64 3.00e-47 185.00
IUUC-Ame-011231 Astyanax mexicanus 57.17 0.00e+00 1889.00
IUUC-Bgr-011999 Blumeria graminis 23.15 1.00e-45 179.00
IUUC-Bta-012347 Bos taurus 94.09 0.00e+00 3311.00
IUUC-Cja-018911 Callithrix jacchus 93.04 0.00e+00 3233.00
IUUC-Cfa-020991 Canis familiaris 95.61 0.00e+00 3370.00
IUUC-Cpo-021448 Cavia porcellus 92.25 0.00e+00 3245.00
IUUC-Cre-022821 Chlamydomonas reinhardtii 28.24 2.40e-01 31.20
IUUC-Csa-024255 Chlorocebus sabaeus 98.25 0.00e+00 2848.00
IUUC-Cho-024550 Choloepus hoffmanni 73.54 0.00e+00 2484.00
IUUC-Dno-029427 Dasypus novemcinctus 93.06 0.00e+00 3184.00
IUUC-Dor-031073 Dipodomys ordii 79.56 0.00e+00 1379.00
IUUC-Ete-032318 Echinops telfairi 76.21 0.00e+00 1271.00
IUUC-Eca-033348 Equus caballus 94.63 0.00e+00 3088.00
IUUC-Eeu-034664 Erinaceus europaeus 85.37 0.00e+00 2986.00
IUUC-Fca-035604 Felis catus 88.99 0.00e+00 3046.00
IUUC-Fal-037333 Ficedula albicollis 78.29 0.00e+00 2709.00
IUUC-Fox-037984 Fusarium oxysporum 26.76 5.00e-40 161.00
IUUC-Gmo-039363 Gadus morhua 56.36 0.00e+00 1660.00
IUUC-Gga-040486 Gallus gallus 77.23 0.00e+00 2662.00
IUUC-Gac-041985 Gasterosteus aculeatus 56.83 0.00e+00 1732.00
IUUC-Ggo-044704 Gorilla gorilla 92.12 0.00e+00 2687.00
IUUC-Itr-048410 Ictidomys tridecemlineatus 95.16 0.00e+00 3336.00
IUUC-Lch-049904 Latimeria chalumnae 61.52 0.00e+00 2114.00
IUUC-Loc-052624 Lepisosteus oculatus 60.91 0.00e+00 2051.00
IUUC-Laf-053857 Loxodonta africana 91.76 0.00e+00 3205.00
IUUC-Mcc-054873 Macaca mulatta 98.34 0.00e+00 3406.00
IUUC-Meu-056858 Macropus eugenii 66.37 0.00e+00 1028.00
IUUC-Mga-059917 Meleagris gallopavo 77.49 0.00e+00 2775.00
IUUC-Mmr-061128 Microcebus murinus 92.47 0.00e+00 3194.00
IUUC-Mdo-062306 Monodelphis domestica 80.84 0.00e+00 2822.00
IUUC-Mmu-063389 Mus musculus 92.15 0.00e+00 3270.00
IUUC-Mpu-065983 Mustela putorius furo 95.27 0.00e+00 3383.00
IUUC-Mlu-068013 Myotis lucifugus 91.68 0.00e+00 3236.00
IUUC-Nle-070031 Nomascus leucogenys 98.80 0.00e+00 3472.00
IUUC-Opr-070551 Ochotona princeps 71.27 0.00e+00 1378.00
IUUC-Ont-072035 Oreochromis niloticus 57.90 0.00e+00 1969.00
IUUC-Ocu-074930 Oryctolagus cuniculus 90.26 0.00e+00 3147.00
IUUC-Oba-075295 Oryza barthii 38.54 6.00e-14 74.70
IUUC-Ogu-078497 Oryza glumaepatula 38.54 5.00e-14 74.70
IUUC-Oin-079343 Oryza indica 38.54 6.00e-14 74.30
IUUC-Oni-083099 Oryza nivara 38.54 6.00e-14 74.70
IUUC-Oru-084471 Oryza rufipogon 38.54 6.00e-14 74.70
IUUC-Osa-086106 Oryza sativa 36.09 1.00e-12 68.90
IUUC-Ola-086683 Oryzias latipes 57.71 0.00e+00 1920.00
IUUC-Oga-088017 Otolemur garnettii 90.35 0.00e+00 3157.00
IUUC-Oar-089557 Ovis aries 93.38 0.00e+00 3299.00
IUUC-Ptr-091366 Pan troglodytes 98.40 0.00e+00 3467.00
IUUC-Pan-092184 Papio anubis 98.23 0.00e+00 3404.00
IUUC-Psi-093720 Pelodiscus sinensis 79.11 0.00e+00 2709.00
IUUC-Ppa-095780 Physcomitrella patens 21.87 1.00e-24 109.00
IUUC-Pfo-097124 Poecilia formosa 57.27 0.00e+00 1939.00
IUUC-Pab-098586 Pongo abelii 98.86 0.00e+00 3471.00
IUUC-Pop-099184 Populus trichocarpa 43.16 5.00e-13 68.90
IUUC-Pca-100673 Procavia capensis 85.07 0.00e+00 1736.00
IUUC-Pva-102724 Pteropus vampyrus 88.71 0.00e+00 3085.00
IUUC-Pte-104174 Pyrenophora teres 23.39 6.00e-49 190.00
IUUC-Pyt-104431 Pyrenophora triticirepentis 23.19 1.00e-47 186.00
IUUC-Rno-105474 Rattus norvegicus 89.17 0.00e+00 2341.00
IUUC-Sha-106993 Sarcophilus harrisii 81.32 0.00e+00 2910.00
IUUC-Sar-113447 Sorex araneus 88.54 0.00e+00 2168.00
IUUC-Ssc-115768 Sus scrofa 90.41 0.00e+00 2959.00
IUUC-Tgu-116949 Taeniopygia guttata 73.40 0.00e+00 2489.00
IUUC-Tru-117782 Takifugu rubripes 56.60 0.00e+00 1929.00
IUUC-Tsy-119177 Tarsius syrichta 84.29 0.00e+00 2263.00
IUUC-Tni-120884 Tetraodon nigroviridis 53.28 0.00e+00 1758.00
IUUC-Tbe-128088 Tupaia belangeri 84.53 0.00e+00 1297.00
IUUC-Ttr-129062 Tursiops truncatus 88.43 0.00e+00 3085.00
IUUC-Vpa-130578 Vicugna pacos 86.59 0.00e+00 2989.00
IUUC-Xtr-132244 Xenopus tropicalis 61.38 0.00e+00 2105.00
Created Date 25-Jun-2017

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