iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003262

Ensembl Protein ID

ENSAPLP00000007227.1

UniProt Accession

U3IJ05; U3IJ05_ANAPL

Genbank Protein ID

ENSAPLP00000007227

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01031189

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000007510.1	ENSAPLT00000007885.1	ENSAPLP00000007227.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-18	66.0	806	857

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 806  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRVGWFPSTYVEE 857
           67**********************************..9*************86 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MEEWRQCGRW LIDCKVLPPN HRVFDLAQAL RDGVLLCQLL HNLSPGSIDL KDINFRPQMS 60
QFLCLKNIRT FLKVCHDKFG LRNSDLFDPF DLFDVRDFGK VISAVSRLSF HSIAQTKGIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAGT GGAGGCAGTG CGGCCGCTGG CTCATCGACT GCAAAGTTTT GCCCCCCAAC 60
CACCGGGTGN NNNNNNNNNN NNNNNGTCTT CGACCTGGCG CAGGCGCTGC GGGACGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	88.73	0.00e+00	1418.00
IUUC-Aca-004628	Anolis carolinensis	68.16	0.00e+00	952.00
IUUC-Ath-007352	Arabidopsis thaliana	34.29	2.00e-03	37.40
IUUC-Ame-011608	Astyanax mexicanus	79.75	0.00e+00	1414.00
IUUC-Bta-013147	Bos taurus	89.43	0.00e+00	1265.00
IUUC-Cja-018877	Callithrix jacchus	88.13	0.00e+00	1355.00
IUUC-Cfa-020315	Canis familiaris	86.13	0.00e+00	1191.00
IUUC-Cpo-021543	Cavia porcellus	88.72	0.00e+00	1283.00
IUUC-Csa-024204	Chlorocebus sabaeus	87.83	0.00e+00	1520.00
IUUC-Cin-025115	Ciona intestinalis	36.06	3.00e-141	495.00
IUUC-Csv-025995	Ciona savignyi	36.44	1.00e-147	516.00
IUUC-Dre-028308	Danio rerio	81.99	0.00e+00	1437.00
IUUC-Dno-029584	Dasypus novemcinctus	83.16	0.00e+00	1105.00
IUUC-Dor-031014	Dipodomys ordii	78.54	0.00e+00	1175.00
IUUC-Eca-033448	Equus caballus	86.79	0.00e+00	1488.00
IUUC-Eeu-035182	Erinaceus europaeus	80.30	0.00e+00	649.00
IUUC-Fca-035460	Felis catus	88.01	0.00e+00	1271.00
IUUC-Fal-036684	Ficedula albicollis	94.51	0.00e+00	1607.00
IUUC-Gmo-038816	Gadus morhua	76.46	0.00e+00	1117.00
IUUC-Gga-040999	Gallus gallus	94.47	0.00e+00	1601.00
IUUC-Gac-041353	Gasterosteus aculeatus	77.73	0.00e+00	1171.00
IUUC-Ggo-044558	Gorilla gorilla	89.64	0.00e+00	1527.00
IUUC-Hsa-046208	Homo sapiens	89.75	0.00e+00	1530.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	86.40	0.00e+00	1160.00
IUUC-Loc-052827	Lepisosteus oculatus	80.45	0.00e+00	1450.00
IUUC-Laf-054009	Loxodonta africana	86.41	0.00e+00	1472.00
IUUC-Mcc-055054	Macaca mulatta	89.64	0.00e+00	1528.00
IUUC-Mla-059044	Melampsora laricipopulina	23.75	1.00e-18	88.60
IUUC-Mga-060106	Meleagris gallopavo	97.93	0.00e+00	1632.00
IUUC-Mmr-061118	Microcebus murinus	88.82	0.00e+00	1519.00
IUUC-Mdo-062380	Monodelphis domestica	87.63	0.00e+00	1278.00
IUUC-Mmu-063135	Mus musculus	91.01	0.00e+00	1567.00
IUUC-Mpu-066135	Mustela putorius furo	85.54	0.00e+00	1385.00
IUUC-Nle-069465	Nomascus leucogenys	83.28	0.00e+00	1398.00
IUUC-Ont-071945	Oreochromis niloticus	81.64	0.00e+00	1414.00
IUUC-Oan-073384	Ornithorhynchus anatinus	87.97	0.00e+00	1205.00
IUUC-Ola-087499	Oryzias latipes	76.50	0.00e+00	1085.00
IUUC-Oga-088444	Otolemur garnettii	86.52	0.00e+00	1248.00
IUUC-Oar-089576	Ovis aries	84.87	0.00e+00	1176.00
IUUC-Ptr-090507	Pan troglodytes	90.78	0.00e+00	1536.00
IUUC-Pan-092325	Papio anubis	88.13	0.00e+00	1498.00
IUUC-Psi-094021	Pelodiscus sinensis	91.23	0.00e+00	1535.00
IUUC-Pma-094372	Petromyzon marinus	54.21	0.00e+00	713.00
IUUC-Pfo-096732	Poecilia formosa	81.43	0.00e+00	1424.00
IUUC-Pab-098426	Pongo abelii	74.32	0.00e+00	1106.00
IUUC-Pca-100295	Procavia capensis	89.31	0.00e+00	1435.00
IUUC-Rno-105332	Rattus norvegicus	89.98	0.00e+00	1498.00
IUUC-Sha-106529	Sarcophilus harrisii	92.04	0.00e+00	1245.00
IUUC-Ssc-116176	Sus scrofa	88.97	0.00e+00	1388.00
IUUC-Tgu-116917	Taeniopygia guttata	97.00	0.00e+00	1489.00
IUUC-Tru-118398	Takifugu rubripes	80.38	0.00e+00	1016.00
IUUC-Tni-120819	Tetraodon nigroviridis	80.73	0.00e+00	1232.00
IUUC-Xtr-132747	Xenopus tropicalis	79.40	0.00e+00	1359.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence