iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066135

Ensembl Protein ID

ENSMPUP00000012096.1

UniProt Accession

M3YL89; M3YL89_MUSPF

Genbank Protein ID

ENSMPUP00000012096

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01042371

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000012192.1	ENSMPUT00000012295.1	ENSMPUP00000012096.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.60e-18	64.7	779	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 779  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--EANGRIGWFPSTYVEE 830
           67**********************************..9*************86 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAGVAGVPAE LGPSPSSPPG SLICHCHACP LRLSAISRVP RWRLSPCPDR CEISVGLGAS 60
QGQFLCLKNI RTFLKVCHDK FGLRNSELFD PFDLFDVRDF GKVISAVSRL SLHHVAQNKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCTGGTGT GGATGGGACC AGAGACACAC GTGGGTACAG ATTGAAGGTT CGCTGGTCTG 60
TTTGCGGCCC GGAGGACGCT GTGCGCATGG CTGGTGTCGC GGGCGTCCCC GCAGAGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000127	Aegilops tauschii	37.10	2.40e-02	34.30
IUUC-Aml-001437	Ailuropoda melanoleuca	90.60	0.00e+00	1408.00
IUUC-Apl-003262	Anas platyrhynchos	85.41	0.00e+00	1372.00
IUUC-Aca-004628	Anolis carolinensis	66.49	0.00e+00	914.00
IUUC-Ath-007352	Arabidopsis thaliana	39.22	3.00e-03	37.40
IUUC-Ame-011608	Astyanax mexicanus	79.85	0.00e+00	1284.00
IUUC-Bta-013147	Bos taurus	90.13	0.00e+00	1268.00
IUUC-Cel-018578	Caenorhabditis elegans	28.07	3.00e-86	313.00
IUUC-Cja-018877	Callithrix jacchus	86.68	0.00e+00	1325.00
IUUC-Cfa-020315	Canis familiaris	97.10	0.00e+00	1279.00
IUUC-Cpo-021543	Cavia porcellus	88.86	0.00e+00	1269.00
IUUC-Csa-024204	Chlorocebus sabaeus	86.86	0.00e+00	1391.00
IUUC-Dre-028308	Danio rerio	76.18	0.00e+00	1250.00
IUUC-Dno-029584	Dasypus novemcinctus	90.50	0.00e+00	1149.00
IUUC-Dor-031014	Dipodomys ordii	81.54	0.00e+00	1209.00
IUUC-Eca-033448	Equus caballus	86.08	0.00e+00	1377.00
IUUC-Eeu-035182	Erinaceus europaeus	83.29	0.00e+00	665.00
IUUC-Fca-035460	Felis catus	93.39	0.00e+00	1345.00
IUUC-Fal-036684	Ficedula albicollis	83.55	0.00e+00	1357.00
IUUC-Gmo-038816	Gadus morhua	78.84	0.00e+00	1114.00
IUUC-Gga-040999	Gallus gallus	88.72	0.00e+00	1392.00
IUUC-Gac-041353	Gasterosteus aculeatus	79.70	0.00e+00	1163.00
IUUC-Ggo-044558	Gorilla gorilla	88.64	0.00e+00	1395.00
IUUC-Hsa-046208	Homo sapiens	88.77	0.00e+00	1398.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	87.59	0.00e+00	1171.00
IUUC-Loc-052827	Lepisosteus oculatus	76.52	0.00e+00	1259.00
IUUC-Laf-054009	Loxodonta africana	86.16	0.00e+00	1352.00
IUUC-Mcc-055054	Macaca mulatta	88.77	0.00e+00	1397.00
IUUC-Meu-056269	Macropus eugenii	76.34	0.00e+00	695.00
IUUC-Mla-059044	Melampsora laricipopulina	24.14	1.00e-19	92.00
IUUC-Mga-060106	Meleagris gallopavo	85.29	0.00e+00	1366.00
IUUC-Mmr-061118	Microcebus murinus	86.55	0.00e+00	1384.00
IUUC-Mdo-062380	Monodelphis domestica	90.15	0.00e+00	1291.00
IUUC-Mmu-063135	Mus musculus	89.86	0.00e+00	1429.00
IUUC-Nle-069465	Nomascus leucogenys	82.38	0.00e+00	1263.00
IUUC-Ont-071945	Oreochromis niloticus	77.87	0.00e+00	1232.00
IUUC-Oan-073384	Ornithorhynchus anatinus	82.99	0.00e+00	1147.00
IUUC-Ola-087499	Oryzias latipes	79.86	0.00e+00	1094.00
IUUC-Oga-088444	Otolemur garnettii	94.11	0.00e+00	1313.00
IUUC-Oar-089576	Ovis aries	86.93	0.00e+00	1211.00
IUUC-Ptr-090507	Pan troglodytes	89.86	0.00e+00	1405.00
IUUC-Pan-092325	Papio anubis	93.08	0.00e+00	1426.00
IUUC-Psi-094021	Pelodiscus sinensis	88.58	0.00e+00	1377.00
IUUC-Pma-094372	Petromyzon marinus	50.79	0.00e+00	673.00
IUUC-Pfo-096732	Poecilia formosa	76.43	0.00e+00	1223.00
IUUC-Pab-098426	Pongo abelii	80.05	0.00e+00	1159.00
IUUC-Pca-100295	Procavia capensis	87.86	0.00e+00	1410.00
IUUC-Rno-105332	Rattus norvegicus	89.74	0.00e+00	1360.00
IUUC-Sha-106529	Sarcophilus harrisii	86.08	0.00e+00	1204.00
IUUC-Sit-110173	Setaria italica	34.09	2.80e-01	30.40
IUUC-Ssc-116176	Sus scrofa	89.69	0.00e+00	1400.00
IUUC-Tgu-116917	Taeniopygia guttata	86.14	0.00e+00	1364.00
IUUC-Tru-118398	Takifugu rubripes	75.28	0.00e+00	941.00
IUUC-Tni-120819	Tetraodon nigroviridis	76.76	0.00e+00	1158.00
IUUC-Tae-123754	Triticum aestivum	35.48	1.10e-01	32.30
IUUC-Xtr-132747	Xenopus tropicalis	79.01	0.00e+00	1236.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence