iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-23	83.3	459	511

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +v ++++yea++ ++L++ +Gdv+lv+   + +e+Wl+g  e +gk G+fP+ Fve
   Q: 459  TQVVAIFSYEAAQPEDLEFVEGDVILVL--SHVNEEWLEG--ECKGKVGIFPKAFVE 511
           5799************************..999*******..9************98 PP

Organism

Mus musculus

Functional Description
(View)

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Protein Sequence
(Fasta)

MSLAEAIRLW NEGVLAADKK DWKGALEAFS EVQDPHSRIC FNIGCVNTIL ENLQAAEQAF 60
TKSINRDKHS AVAYFQRGML YYRMEKYDLA IKDLKEALTQ LRGNQLIDYK ILGLQFKLFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTCCCA CACAGCTATA ATAAACTCTC TCCTCCACCA TATCTGGGAA CAGTCATGTT 60
CCTTTTCCTT TCTTATTTCT TTTCTTTCTT TTTCTTTTTT TTTTTTCCCA TTCAGAGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0802--TPR repeat

Interpro

IPR000270--PB1_dom
IPR001452--SH3_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat

PROSITE

PS51745--PB1
PS50002--SH3
PS50005--TPR
PS50293--TPR_REGION

Pfam

PF00564--PB1
PF00018--SH3_1
PF00515--TPR_1
PF13181--TPR_8

PRINTS

PR00452--SH3DOMAIN

SMART

SM00666--PB1
SM00326--SH3
SM00028--TPR

Gene Ontology

GO:0001669--C:acrosomal vesicle
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0008022--F:protein C-terminus binding
GO:0048365--F:Rac GTPase binding
GO:0006742--P:NADP catabolic process
GO:0055114--P:oxidation-reduction process
GO:0042554--P:superoxide anion generation
GO:0006801--P:superoxide metabolic process

KEGG

mmu:17970

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001888	Ailuropoda melanoleuca	83.11	0.00e+00	793.00
IUUC-Apl-003924	Anas platyrhynchos	59.96	4.00e-175	607.00
IUUC-Aca-005068	Anolis carolinensis	59.30	7.00e-170	590.00
IUUC-Ame-011744	Astyanax mexicanus	44.23	4.00e-118	418.00
IUUC-Bta-012540	Bos taurus	83.30	0.00e+00	822.00
IUUC-Cja-018958	Callithrix jacchus	73.27	0.00e+00	732.00
IUUC-Cfa-020476	Canis familiaris	80.49	0.00e+00	745.00
IUUC-Cpo-021978	Cavia porcellus	84.96	0.00e+00	754.00
IUUC-Csa-023697	Chlorocebus sabaeus	84.98	0.00e+00	808.00
IUUC-Dre-028554	Danio rerio	44.66	5.00e-119	421.00
IUUC-Dno-029212	Dasypus novemcinctus	85.55	0.00e+00	792.00
IUUC-Dor-030205	Dipodomys ordii	75.97	0.00e+00	650.00
IUUC-Ete-032956	Echinops telfairi	82.96	5.00e-105	374.00
IUUC-Eca-033281	Equus caballus	82.32	0.00e+00	781.00
IUUC-Fca-036178	Felis catus	81.56	0.00e+00	787.00
IUUC-Fal-037379	Ficedula albicollis	59.96	5.00e-167	580.00
IUUC-Gmo-039472	Gadus morhua	43.27	5.00e-112	397.00
IUUC-Gga-040921	Gallus gallus	59.39	6.00e-172	597.00
IUUC-Gac-042198	Gasterosteus aculeatus	44.62	2.00e-111	395.00
IUUC-Ggo-045435	Gorilla gorilla	77.02	0.00e+00	793.00
IUUC-Hsa-046273	Homo sapiens	84.60	0.00e+00	805.00
IUUC-Itr-048611	Ictidomys tridecemlineatus	84.60	0.00e+00	791.00
IUUC-Lch-049997	Latimeria chalumnae	47.41	5.00e-133	468.00
IUUC-Loc-052742	Lepisosteus oculatus	50.38	6.00e-137	481.00
IUUC-Laf-053863	Loxodonta africana	85.16	0.00e+00	786.00
IUUC-Mcc-054727	Macaca mulatta	84.79	0.00e+00	805.00
IUUC-Meu-056768	Macropus eugenii	62.88	4.00e-177	614.00
IUUC-Mga-059583	Meleagris gallopavo	58.91	7.00e-171	593.00
IUUC-Mvi-060542	Microbotryum violaceum	45.10	5.00e-11	61.20
IUUC-Mmr-060852	Microcebus murinus	81.17	0.00e+00	780.00
IUUC-Mdo-062806	Monodelphis domestica	76.86	0.00e+00	775.00
IUUC-Mpu-066159	Mustela putorius furo	82.13	0.00e+00	757.00
IUUC-Mlu-067637	Myotis lucifugus	73.66	0.00e+00	753.00
IUUC-Nle-068999	Nomascus leucogenys	84.98	0.00e+00	802.00
IUUC-Opr-070374	Ochotona princeps	73.84	1.00e-111	397.00
IUUC-Ont-072616	Oreochromis niloticus	41.65	3.00e-113	402.00
IUUC-Oan-072977	Ornithorhynchus anatinus	60.87	7.00e-91	328.00
IUUC-Ocu-073762	Oryctolagus cuniculus	76.10	0.00e+00	714.00
IUUC-Ola-086389	Oryzias latipes	44.38	6.00e-119	421.00
IUUC-Oga-088801	Otolemur garnettii	84.03	0.00e+00	823.00
IUUC-Oar-090317	Ovis aries	83.11	0.00e+00	810.00
IUUC-Ptr-091639	Pan troglodytes	84.98	0.00e+00	805.00
IUUC-Pan-092699	Papio anubis	84.60	0.00e+00	803.00
IUUC-Psi-093682	Pelodiscus sinensis	64.39	0.00e+00	640.00
IUUC-Pfo-097064	Poecilia formosa	42.88	1.00e-115	409.00
IUUC-Pab-098199	Pongo abelii	84.79	0.00e+00	805.00
IUUC-Pca-100910	Procavia capensis	59.78	1.00e-169	589.00
IUUC-Pva-102487	Pteropus vampyrus	74.96	0.00e+00	776.00
IUUC-Sha-106930	Sarcophilus harrisii	76.01	0.00e+00	768.00
IUUC-Sja-107963	Schizosaccharomyces japonicus	40.98	3.00e-07	51.60
IUUC-Ssc-115647	Sus scrofa	83.17	0.00e+00	797.00
IUUC-Tgu-116783	Taeniopygia guttata	59.73	3.00e-167	581.00
IUUC-Tru-118473	Takifugu rubripes	42.88	5.00e-110	391.00
IUUC-Tsy-119120	Tarsius syrichta	55.46	6.00e-61	228.00
IUUC-Tni-119900	Tetraodon nigroviridis	43.39	3.00e-115	409.00
IUUC-Tbe-127725	Tupaia belangeri	67.50	1.00e-142	499.00
IUUC-Ttr-128426	Tursiops truncatus	71.33	0.00e+00	719.00
IUUC-Xtr-132656	Xenopus tropicalis	52.07	2.00e-145	508.00
IUUC-Xma-134150	Xiphophorus maculatus	43.54	1.00e-116	413.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence