iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cin-025513

Ensembl Protein ID

ENSCINP00000007054.3

UniProt Accession

F6WYA1; F6WYA1_CIOIN

Protein Name

Tyrosine-protein kinase

Gene Name

LOC100176191

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000003438.3	ENSCINT00000007054.3	ENSCINP00000007054.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.60e-11	42.6	11	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++  +d++  n+++L +kkGd++ vi + + d +W +++ + +g +G++P n++++
   Q: 11   TCEGVFDFNTGNKGDLPFKKGDTLVVI-QRTRDPNWYRAQ-NSKGESGMVPLNYITQ 65
           78999**********************.***********7.**************97 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

LLFQTIPNGT TCEGVFDFNT GNKGDLPFKK GDTLVVIQRT RDPNWYRAQN SKGESGMVPL 60
NYITQHKEVK LTAMPWFHGK ITRSDAEDLL TPRKDGLFLV RESTNYPGDY TMCVSFAGEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTGTTTC AGACAATACC AAATGGGACG ACATGTGAAG GAGTATTTGA TTTCAACACC 60
GGCAATAAAG GAGACCTCCC GTTTAAGAAA GGAGATACAC TTGTAGTTAT TCAAGTAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004391	Anolis carolinensis	54.36	3.00e-145	506.00
IUUC-Bol-015857	Brassica oleracea	31.25	2.00e-21	95.50
IUUC-Cre-022669	Chlamydomonas reinhardtii	27.78	2.00e-16	78.60
IUUC-Csv-025899	Ciona savignyi	79.12	0.00e+00	779.00
IUUC-Fal-037215	Ficedula albicollis	55.48	1.00e-148	518.00
IUUC-Gmo-039103	Gadus morhua	54.26	5.00e-144	502.00
IUUC-Gga-040506	Gallus gallus	55.70	2.00e-148	517.00
IUUC-Loc-052586	Lepisosteus oculatus	54.65	7.00e-146	508.00
IUUC-Meu-056387	Macropus eugenii	54.85	3.00e-146	510.00
IUUC-Mga-060040	Meleagris gallopavo	53.91	2.00e-142	497.00
IUUC-Mdo-061871	Monodelphis domestica	54.85	3.00e-146	510.00
IUUC-Ont-072457	Oreochromis niloticus	54.94	4.00e-145	506.00
IUUC-Ola-087105	Oryzias latipes	53.93	3.00e-145	506.00
IUUC-Oga-087928	Otolemur garnettii	54.85	8.00e-145	505.00
IUUC-Pfo-096126	Poecilia formosa	54.94	1.00e-145	508.00
IUUC-Sha-106987	Sarcophilus harrisii	54.85	2.00e-146	510.00
IUUC-Tru-118712	Takifugu rubripes	53.79	2.00e-143	501.00
IUUC-Tni-119856	Tetraodon nigroviridis	54.48	8.00e-145	505.00
IUUC-Xtr-132763	Xenopus tropicalis	53.24	3.00e-139	486.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence