iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132763

Ensembl Protein ID

ENSXETP00000045692.3

UniProt Accession

F6UTP2; F6UTP2_XENTR

Genbank Protein ID

ENSXETP00000045692

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01070898

Gene Name

csk

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021139.3	ENSXETT00000045692.3	ENSXETP00000045692.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.50e-11	42.4	13	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++ yd++++ + +L + kG+v++++   ++d +W k+ k+  g+ G++P+n+v+k
   Q: 13   ECIANYDFQGKAEQDLHFSKGEVLTIV-AVTKDPNWYKA-KNKVGRVGFIPANYVQK 67
           68999**********************.***********.6**************87 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSVVQAPWQA GTECIANYDF QGKAEQDLHF SKGEVLTIVA VTKDPNWYKA KNKVGRVGFI 60
PANYVQKREG VKSGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

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Nucleotide Sequence
(Fasta)

GCATGCCCAA TTCCGCGGGT GGACCTGGCA CCGTTTCCTC TGTCAGGGCC GCGTTTGAGA 60
AGACAGTGAG CGGAGGCCTT CCCAAAATAA CCGAAGCGAA CCGGGACGTA GTGCGCCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0034332--P:adherens junction organization
GO:0030154--P:cell differentiation
GO:0007417--P:central nervous system development
GO:0060027--P:convergent extension involved in gastrulation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0001817--P:regulation of cytokine production
GO:0060368--P:regulation of Fc receptor mediated stimulatory signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004391	Anolis carolinensis	83.59	0.00e+00	795.00
IUUC-Cin-025513	Ciona intestinalis	53.24	7.00e-139	486.00
IUUC-Csv-025899	Ciona savignyi	50.31	1.00e-130	459.00
IUUC-Fal-037215	Ficedula albicollis	85.37	0.00e+00	803.00
IUUC-Gmo-039103	Gadus morhua	80.22	0.00e+00	761.00
IUUC-Gga-040506	Gallus gallus	84.70	0.00e+00	799.00
IUUC-Loc-052586	Lepisosteus oculatus	82.71	0.00e+00	795.00
IUUC-Meu-056387	Macropus eugenii	85.78	0.00e+00	807.00
IUUC-Mga-060040	Meleagris gallopavo	83.45	0.00e+00	778.00
IUUC-Mdo-061871	Monodelphis domestica	85.11	0.00e+00	801.00
IUUC-Ont-072457	Oreochromis niloticus	80.22	0.00e+00	757.00
IUUC-Ola-087366	Oryzias latipes	82.22	0.00e+00	757.00
IUUC-Oga-087928	Otolemur garnettii	84.00	0.00e+00	797.00
IUUC-Pfo-096126	Poecilia formosa	79.51	0.00e+00	758.00
IUUC-Sha-106987	Sarcophilus harrisii	85.56	0.00e+00	807.00
IUUC-Tru-118712	Takifugu rubripes	77.32	0.00e+00	733.00
IUUC-Tni-119856	Tetraodon nigroviridis	77.75	0.00e+00	737.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence