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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032041
UUCD1 version UUC-DrM-00047
Ensembl Protein ID FBpp0077495
UniProt Accession Q9Y0H4; A4UZZ3; Q0E8U5; Q8T0C8; SUDX_DROME
Genbank Protein ID AAD38975.1; AAF51311.1; AAN10440.1; AAX33538.1; AAL39551.1
Protein Name E3 ubiquitin-protein ligase Su(dx); HECT-type E3 ubiquitin transferase Su(dx); Protein suppressor of deltex
Genbank Nucleotide ID AF152865; AE014134; AE014134; BT021390; AY069406
Gene Name Su(dx); CG4244
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003557 FBtr0077822 FBpp0077495
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 18628966
Classification
Family E-value Score Start End
E3 activity/HECT 6.60e-132 440.0 618 947
Active Site
Position(s) Description Evidence
917 Glycyl thioester intermediate {ECO:0000305}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
           +l++rl++ f+gEegld+gGv+re+++lls+e+ np+++lf+y ++++++lq+np+s++ np+hl++F+f+Gr++++al++gr++   ++ +fyk++l
   Q: 618  ELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYV-NPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRML 714
           6899******************************************************9.89************************************ PP
   S: 102  gkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfne 199
           +kkl+++d+e++dpe+y+sl ++k+n   +i+e+gl+l fsv+ e+lg++ ++eLk++Ge+++Vt+eNkeeY+ l++e+r+++gi++q++ f eGfne
   Q: 715  NKKLTIKDIETIDPEFYNSLIWVKDN---NIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNE 809
           ************************99...9******************************************************************** PP
   S: 200  viplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkda 293
           v+ple+l++F+e+elel++cG++++dved++++t y++ y+++s+++ wFw++++e ++e+r+++LqFvTg++r+P+gGfael+    p++f+i+k +
   Q: 810  VVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMgsngPQRFCIEKVG 906
           ************************************99.*********************************************************** PP
   S: 294  sddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           ++++lP+s+TCfn+L+LP+Y+s+++l ekL++Aieet+gF 
   Q: 907  KETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFC 947
           ****************************************6 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.
Protein Sequence
(Fasta)
MADGNGLPAG AASGGMEAGQ TVNGAGSASP TPTSSSGAGA SGSANQGYHQ LSVTIEEASL 60
RNNGFLKPNP YVELLIDSKS KRKTDLVKNS YLPKWNEEFT VLITPNSTLH FKVLDHSSFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032041|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTATCGAAA AACATCGTCC AAAGTTGCAG CTCTAGAAAT TGCTGCTTGC AAGCGAAGCA 60
AAATAACAAA TAAACAATTA GTGCAGCGAT ATCAACTGCT CGCGATTACG TGGACCAAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032041|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0005112--F:Notch binding
GO:0019904--F:protein domain specific binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016348--P:imaginal disc-derived leg joint morphogenesis
GO:0008587--P:imaginal disc-derived wing margin morphogenesis
GO:0008586--P:imaginal disc-derived wing vein morphogenesis
GO:0019915--P:lipid storage
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
GO:0035209--P:pupal development
GO:0031623--P:receptor internalization
GO:0032880--P:regulation of protein localization
GO:0048190--P:wing disc dorsal/ventral pattern formation
KEGG dme:Dmel_CG4244
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001213 Ailuropoda melanoleuca 53.80 0.00e+00 927.00
IUUC-Apl-003310 Anas platyrhynchos 71.72 0.00e+00 894.00
IUUC-Aca-005388 Anolis carolinensis 69.90 0.00e+00 887.00
IUUC-Ago-007742 Ashbya gossypii 45.09 3.00e-150 525.00
IUUC-Acl-008273 Aspergillus clavatus 46.83 8.00e-151 526.00
IUUC-Afl-008713 Aspergillus flavus 45.67 2.00e-146 512.00
IUUC-Afu-009103 Aspergillus fumigatus 47.17 5.00e-152 530.00
IUUC-Ani-009259 Aspergillus nidulans 45.20 6.00e-147 513.00
IUUC-Ang-009738 Aspergillus niger 44.37 3.00e-146 511.00
IUUC-Ate-010529 Aspergillus terreus 46.41 2.00e-149 522.00
IUUC-Ame-010601 Astyanax mexicanus 65.05 0.00e+00 830.00
IUUC-Bgr-012148 Blumeria graminis 44.48 9.00e-142 496.00
IUUC-Bta-012857 Bos taurus 70.29 0.00e+00 897.00
IUUC-Cel-018299 Caenorhabditis elegans 67.85 0.00e+00 843.00
IUUC-Cja-019448 Callithrix jacchus 71.52 0.00e+00 899.00
IUUC-Cfa-020728 Canis familiaris 70.13 0.00e+00 899.00
IUUC-Cpo-021988 Cavia porcellus 68.76 0.00e+00 892.00
IUUC-Csa-023805 Chlorocebus sabaeus 71.29 0.00e+00 885.00
IUUC-Cho-024695 Choloepus hoffmanni 63.99 0.00e+00 835.00
IUUC-Cin-025212 Ciona intestinalis 69.04 0.00e+00 860.00
IUUC-Csv-026256 Ciona savignyi 69.07 0.00e+00 845.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 44.62 2.00e-143 502.00
IUUC-Cne-026849 Cryptococcus neoformans 46.09 2.00e-150 525.00
IUUC-Dre-028245 Danio rerio 70.45 0.00e+00 907.00
IUUC-Dno-029618 Dasypus novemcinctus 71.36 0.00e+00 897.00
IUUC-Dor-030176 Dipodomys ordii 69.91 0.00e+00 871.00
IUUC-Dse-031241 Dothistroma septosporum 46.79 4.00e-149 521.00
IUUC-Ete-032779 Echinops telfairi 68.49 0.00e+00 824.00
IUUC-Eca-033313 Equus caballus 70.98 0.00e+00 889.00
IUUC-Eeu-035259 Erinaceus europaeus 63.56 0.00e+00 754.00
IUUC-Fca-035420 Felis catus 70.29 0.00e+00 900.00
IUUC-Fal-037335 Ficedula albicollis 53.97 0.00e+00 948.00
IUUC-Fox-037774 Fusarium oxysporum 45.49 7.00e-145 506.00
IUUC-Fso-038393 Fusarium solani 45.03 5.00e-142 497.00
IUUC-Gmo-038842 Gadus morhua 67.52 0.00e+00 819.00
IUUC-Ggr-040107 Gaeumannomyces graminis 44.54 1.00e-143 503.00
IUUC-Gga-040246 Gallus gallus 71.57 0.00e+00 898.00
IUUC-Gac-042211 Gasterosteus aculeatus 71.24 0.00e+00 914.00
IUUC-Ggo-045001 Gorilla gorilla 71.19 0.00e+00 896.00
IUUC-Hsa-046544 Homo sapiens 71.19 0.00e+00 897.00
IUUC-Itr-048860 Ictidomys tridecemlineatus 71.36 0.00e+00 897.00
IUUC-Kpa-049273 Komagataella pastoris 46.63 9.00e-155 540.00
IUUC-Lch-050398 Latimeria chalumnae 71.29 0.00e+00 902.00
IUUC-Loc-052116 Lepisosteus oculatus 71.03 0.00e+00 920.00
IUUC-Laf-053551 Loxodonta africana 69.72 0.00e+00 889.00
IUUC-Mcc-055655 Macaca mulatta 69.57 0.00e+00 878.00
IUUC-Meu-055953 Macropus eugenii 60.58 0.00e+00 737.00
IUUC-Mor-057097 Magnaporthe oryzae 44.65 2.00e-143 502.00
IUUC-Mla-058996 Melampsora laricipopulina 51.33 5.00e-145 507.00
IUUC-Mga-059986 Meleagris gallopavo 54.28 0.00e+00 950.00
IUUC-Mmr-060896 Microcebus murinus 70.26 0.00e+00 883.00
IUUC-Mdo-062536 Monodelphis domestica 69.49 0.00e+00 881.00
IUUC-Mmu-063202 Mus musculus 71.36 0.00e+00 894.00
IUUC-Mpu-065773 Mustela putorius furo 70.06 0.00e+00 898.00
IUUC-Mlu-067623 Myotis lucifugus 67.69 0.00e+00 835.00
IUUC-Nfi-068427 Neosartorya fischeri 47.17 8.00e-152 530.00
IUUC-Ncr-068918 Neurospora crassa 43.61 4.00e-143 501.00
IUUC-Nle-069188 Nomascus leucogenys 71.52 0.00e+00 899.00
IUUC-Opr-070965 Ochotona princeps 70.52 0.00e+00 877.00
IUUC-Ont-072226 Oreochromis niloticus 71.74 0.00e+00 922.00
IUUC-Oan-073497 Ornithorhynchus anatinus 71.33 0.00e+00 892.00
IUUC-Ocu-074271 Oryctolagus cuniculus 69.40 0.00e+00 877.00
IUUC-Ola-087438 Oryzias latipes 70.69 0.00e+00 915.00
IUUC-Oga-087922 Otolemur garnettii 70.06 0.00e+00 895.00
IUUC-Oar-089429 Ovis aries 70.13 0.00e+00 893.00
IUUC-Ptr-090484 Pan troglodytes 71.19 0.00e+00 897.00
IUUC-Pan-092117 Papio anubis 71.52 0.00e+00 899.00
IUUC-Psi-093338 Pelodiscus sinensis 54.19 0.00e+00 952.00
IUUC-Pma-094279 Petromyzon marinus 62.14 0.00e+00 710.00
IUUC-Pno-095118 Phaeosphaeria nodorum 45.95 2.00e-149 522.00
IUUC-Pfo-096171 Poecilia formosa 71.17 0.00e+00 921.00
IUUC-Pab-098654 Pongo abelii 70.02 0.00e+00 869.00
IUUC-Pca-100596 Procavia capensis 74.06 0.00e+00 775.00
IUUC-Pva-102811 Pteropus vampyrus 70.15 0.00e+00 890.00
IUUC-Pgr-103620 Puccinia graminis 50.72 5.00e-142 497.00
IUUC-Pte-104016 Pyrenophora teres 46.53 9.00e-150 523.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 46.53 9.00e-150 523.00
IUUC-Rno-106125 Rattus norvegicus 71.36 0.00e+00 894.00
IUUC-Sce-106289 Saccharomyces cerevisiae 45.73 8.00e-152 530.00
IUUC-Sha-107243 Sarcophilus harrisii 69.49 0.00e+00 881.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 48.95 7.00e-149 520.00
IUUC-Spo-108171 Schizosaccharomyces pombe 47.41 2.00e-154 539.00
IUUC-Sar-113761 Sorex araneus 65.19 0.00e+00 820.00
IUUC-Sre-114929 Sporisorium reilianum 44.83 6.00e-148 517.00
IUUC-Ssc-115368 Sus scrofa 70.06 0.00e+00 892.00
IUUC-Tgu-117079 Taeniopygia guttata 71.24 0.00e+00 894.00
IUUC-Tru-118062 Takifugu rubripes 69.67 0.00e+00 920.00
IUUC-Tsy-119507 Tarsius syrichta 51.45 0.00e+00 872.00
IUUC-Tni-120151 Tetraodon nigroviridis 70.03 0.00e+00 905.00
IUUC-Tvi-122595 Trichoderma virens 44.16 6.00e-141 494.00
IUUC-Tbe-127793 Tupaia belangeri 64.09 0.00e+00 774.00
IUUC-Ttr-128275 Tursiops truncatus 69.91 0.00e+00 878.00
IUUC-Vda-129753 Verticillium dahliae 44.39 1.00e-142 499.00
IUUC-Vpa-130103 Vicugna pacos 51.78 0.00e+00 671.00
IUUC-Xtr-132866 Xenopus tropicalis 67.33 0.00e+00 859.00
IUUC-Xma-133778 Xiphophorus maculatus 71.17 0.00e+00 920.00
Created Date 25-Jun-2017

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