iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033313

UUCD1 version

UUC-EqC-00469

Ensembl Protein ID

ENSECAP00000007045.1

UniProt Accession

F6XJT5; F6XJT5_HORSE

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000008529.1	ENSECAT00000009281.1	ENSECAP00000007045.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.00e-133	443.1	589	920

Active Site

Position(s)	Description	Evidence
889	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 676
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk+gG+ni Vt++Nk+eY+ l++e
   Q: 677  GFSLPFYKRMLNKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKSGGSNILVTEDNKDEYIGLMTE 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d+++++ y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 763  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNAVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk...prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGf+ +    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  TGTCRLPLGGFELMGdngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 920
           ************9999****************************************************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MATASPRSDT GNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATID LKQALLIHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTCGCTA GACTATGAGC GCCTTGGAAG AAGGAATCGT GTCTTACTCA TCTTTATATC 60
CTCAGTGTCT AGTACAGTTC CTGGTACATA GTAAGTGATT CCCTTTTTTT TTAATTAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	92.52	0.00e+00	1702.00
IUUC-Apl-003310	Anas platyrhynchos	83.30	0.00e+00	1524.00
IUUC-Aca-005388	Anolis carolinensis	79.91	0.00e+00	1431.00
IUUC-Bta-012857	Bos taurus	91.87	0.00e+00	1664.00
IUUC-Cja-019448	Callithrix jacchus	92.73	0.00e+00	1718.00
IUUC-Cfa-020728	Canis familiaris	93.38	0.00e+00	1702.00
IUUC-Cpo-021635	Cavia porcellus	88.23	0.00e+00	1627.00
IUUC-Csa-023805	Chlorocebus sabaeus	94.39	0.00e+00	1271.00
IUUC-Cho-024943	Choloepus hoffmanni	82.35	0.00e+00	1143.00
IUUC-Cin-025212	Ciona intestinalis	73.53	0.00e+00	902.00
IUUC-Csv-026256	Ciona savignyi	72.32	0.00e+00	894.00
IUUC-Dre-028245	Danio rerio	70.51	0.00e+00	1206.00
IUUC-Dno-029618	Dasypus novemcinctus	92.95	0.00e+00	1712.00
IUUC-Dor-030665	Dipodomys ordii	76.19	0.00e+00	1129.00
IUUC-Dme-032041	Drosophila melanogaster	70.81	0.00e+00	893.00
IUUC-Ete-032779	Echinops telfairi	94.19	0.00e+00	1102.00
IUUC-Eeu-035259	Erinaceus europaeus	84.16	0.00e+00	1516.00
IUUC-Fca-035420	Felis catus	91.97	0.00e+00	1696.00
IUUC-Fal-037335	Ficedula albicollis	81.57	0.00e+00	1498.00
IUUC-Gmo-039172	Gadus morhua	86.62	0.00e+00	1045.00
IUUC-Gga-040246	Gallus gallus	82.38	0.00e+00	1508.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.13	0.00e+00	1156.00
IUUC-Ggo-045001	Gorilla gorilla	91.62	0.00e+00	1500.00
IUUC-Hsa-046544	Homo sapiens	92.19	0.00e+00	1706.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	90.91	0.00e+00	1637.00
IUUC-Lch-050398	Latimeria chalumnae	77.00	0.00e+00	1374.00
IUUC-Loc-052116	Lepisosteus oculatus	93.68	0.00e+00	1170.00
IUUC-Laf-053551	Loxodonta africana	91.98	0.00e+00	1672.00
IUUC-Mga-059986	Meleagris gallopavo	82.61	0.00e+00	1524.00
IUUC-Mmr-060945	Microcebus murinus	90.03	0.00e+00	1644.00
IUUC-Mdo-063024	Monodelphis domestica	82.11	0.00e+00	1465.00
IUUC-Mmu-063202	Mus musculus	88.07	0.00e+00	1580.00
IUUC-Mpu-065773	Mustela putorius furo	93.07	0.00e+00	1694.00
IUUC-Mlu-067373	Myotis lucifugus	96.46	0.00e+00	642.00
IUUC-Nle-069188	Nomascus leucogenys	92.62	0.00e+00	1713.00
IUUC-Opr-070965	Ochotona princeps	87.53	0.00e+00	1595.00
IUUC-Ont-072226	Oreochromis niloticus	91.36	0.00e+00	1162.00
IUUC-Oan-073497	Ornithorhynchus anatinus	86.02	0.00e+00	1533.00
IUUC-Ocu-073891	Oryctolagus cuniculus	88.08	0.00e+00	1568.00
IUUC-Ola-087438	Oryzias latipes	91.19	0.00e+00	1154.00
IUUC-Oga-087922	Otolemur garnettii	91.56	0.00e+00	1665.00
IUUC-Oar-089317	Ovis aries	90.80	0.00e+00	1647.00
IUUC-Ptr-090484	Pan troglodytes	92.19	0.00e+00	1705.00
IUUC-Pan-092117	Papio anubis	92.41	0.00e+00	1709.00
IUUC-Psi-093338	Pelodiscus sinensis	84.18	0.00e+00	1538.00
IUUC-Pma-094279	Petromyzon marinus	72.59	0.00e+00	835.00
IUUC-Pfo-096171	Poecilia formosa	91.53	0.00e+00	1159.00
IUUC-Pab-098654	Pongo abelii	91.79	0.00e+00	1230.00
IUUC-Pca-100501	Procavia capensis	72.52	0.00e+00	891.00
IUUC-Pva-102811	Pteropus vampyrus	80.37	0.00e+00	1417.00
IUUC-Rno-106125	Rattus norvegicus	87.96	0.00e+00	1598.00
IUUC-Sha-107243	Sarcophilus harrisii	84.70	0.00e+00	1536.00
IUUC-Ssc-115368	Sus scrofa	92.54	0.00e+00	1675.00
IUUC-Tgu-117079	Taeniopygia guttata	81.66	0.00e+00	1486.00
IUUC-Tru-118062	Takifugu rubripes	70.90	0.00e+00	1337.00
IUUC-Tsy-119507	Tarsius syrichta	87.64	0.00e+00	1587.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.94	0.00e+00	1150.00
IUUC-Ttr-129260	Tursiops truncatus	82.32	0.00e+00	1444.00
IUUC-Vpa-130390	Vicugna pacos	81.73	0.00e+00	904.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence