iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000009204.1	ENSONIT00000011582.1	ENSONIP00000011573.1
ENSONIG00000009204.1	ENSONIT00000011583.1	ENSONIP00000011574.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-136	454.7	575	907

Active Site

Position(s)	Description	Evidence
876	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 575  AQDLRRRLWIIFPGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 662
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l+l+dle++dpe+y+sl++ik+n   diee+gl++ fsv++eilge++++eLkpgG +i+Vt+eNkeeY++lv+e
   Q: 663  GFSLPFYKRILNKPLTLHDLESIDPEFYNSLMWIKDN---DIEECGLEMFFSVDKEILGEISTHELKPGGGDIQVTEENKEEYIRLVAE 748
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid+ d++++t y++ y ++s++i wFw+ ++e+++e+r ++LqFv
   Q: 749  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLVDWQRNTIYRH-YARSSKQIVWFWQLVKEMDNEKRMRLLQFV 836
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf++l+     ++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 837  TGTCRLPVGGFNDLMgsngAQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLMFAIEETEGFGQ 907
           *******************9*************************************************96 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MASGATKSGT SNGYPIRAQL QIIVLSAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCTNT 60
HSPKWKQPLT VIVTPFSKLV FRVWSHQTLK SDLLLGMATL DVSETLKSND MKISEVVQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCACTCCA CCTTGTTTCG ATCACGTGAC ATGAGCTTAC GAAGATGGTG GAAGTTTCTT 60
CTTCCTTGAA GTGAAACCCC CACCAGAAAC CCAAACATCC TGGTGAGCGA AGGCTGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0048920--P:posterior lateral line neuromast primordium migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bgr-012148	Blumeria graminis	46.40	1.00e-148	520.00
IUUC-Bci-013785	Botrytis cinerea	45.89	4.00e-150	525.00
IUUC-Cho-024695	Choloepus hoffmanni	69.97	0.00e+00	1262.00
IUUC-Dre-028451	Danio rerio	75.90	0.00e+00	1382.00
IUUC-Ggo-044535	Gorilla gorilla	70.41	0.00e+00	1277.00
IUUC-Hsa-046564	Homo sapiens	72.72	0.00e+00	1314.00
IUUC-Kpa-049273	Komagataella pastoris	46.03	6.00e-162	564.00
IUUC-Loc-052647	Lepisosteus oculatus	74.60	0.00e+00	1412.00
IUUC-Mmr-061135	Microcebus murinus	72.83	0.00e+00	1318.00
IUUC-Ptr-090819	Pan troglodytes	72.06	0.00e+00	1275.00
IUUC-Psi-093319	Pelodiscus sinensis	69.74	0.00e+00	1246.00
IUUC-Pfo-097346	Poecilia formosa	90.54	0.00e+00	1187.00
IUUC-Pab-097580	Pongo abelii	62.89	0.00e+00	1094.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	47.45	6.00e-151	528.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.83	6.00e-151	528.00
IUUC-Sre-114929	Sporisorium reilianum	46.96	7.00e-155	541.00
IUUC-Tru-118442	Takifugu rubripes	91.37	0.00e+00	1179.00
IUUC-Tsy-119198	Tarsius syrichta	67.22	0.00e+00	1141.00
IUUC-Tre-122203	Trichoderma reesei	46.53	3.00e-151	529.00
IUUC-Tvi-122595	Trichoderma virens	46.49	2.00e-151	529.00
IUUC-Xtr-132885	Xenopus tropicalis	71.98	0.00e+00	1321.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence