iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000009551.1	ENSSHAT00000011184.1	ENSSHAP00000011090.1
ENSSHAG00000009551.1	ENSSHAT00000011185.1	ENSSHAP00000011091.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-49	167.9	4245	4573

Active Site

Position(s)	Description	Evidence
4542	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4245 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaarssLHTNMFRFLGVLLGIAIRTGSPL 4331
           4566*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eYv+
   Q: 4332 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRAEYVR 4413
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedl..kketkykggytedspaiqwFwevleefssee 260
           l ++yr+ + +k+++ +++   + + p  +l lF+   + +l+     ++v+++  + + ++  g+ +ds+     +   + ++s  
   Q: 4414 LAINYRFGNFVKKEILSISLNSYIIHPHMVLGLFDGVSFHVLLKAL--WSVPKVliRPQKNF--GILSDSRSP---LVSNCLLTSSP 4493
           *******************99999*******************999..66666511455566..666666653...23457799999 PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirk.....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++ f +F++ ++   ++ +   k r+f ir+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4494 KRLFSRFLSVRNDSLHKKIHVYKFRFFYIRQvldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4573
           9*********9999999999999***********988888***********************************99875 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

KGVEGLARVG SRAALSFAFA FLRRAWRSGE DADLCSELLQ ESLDALRALP EASLFDESTV 60
SSVWLEVVER ATKFLRSVVT GDVHGTASTK GPGNIPLQDQ HLALAILLEL AVQRGTLSQM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGGTGTAG AAGGACTTGC AAGAGTTGGA TCCAGAGCAG CCCTTTCATT TGCTTTTGCA 60
TTCCTACGCA GAGCTTGGCG GTCAGGTAAA GTTGAGCTAC ATTTTTTAGT TTCCAAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	84.69	0.00e+00	6141.00
IUUC-Atr-003065	Amborella trichopoda	35.59	1.00e-51	198.00
IUUC-Apl-003983	Anas platyrhynchos	82.63	0.00e+00	7151.00
IUUC-Aca-004300	Anolis carolinensis	83.62	0.00e+00	7137.00
IUUC-Aly-006441	Arabidopsis lyrata	34.15	3.00e-45	177.00
IUUC-Ame-010621	Astyanax mexicanus	81.64	0.00e+00	5737.00
IUUC-Bta-013067	Bos taurus	79.85	0.00e+00	6829.00
IUUC-Bdi-014093	Brachypodium distachyon	33.76	8.00e-50	192.00
IUUC-Bol-015203	Brassica oleracea	34.27	1.00e-52	201.00
IUUC-Bra-016737	Brassica rapa	34.27	5.00e-48	186.00
IUUC-Cja-019687	Callithrix jacchus	81.24	0.00e+00	6866.00
IUUC-Cfa-020672	Canis familiaris	80.35	0.00e+00	6902.00
IUUC-Cpo-021819	Cavia porcellus	79.27	0.00e+00	6685.00
IUUC-Csa-023817	Chlorocebus sabaeus	80.28	0.00e+00	6838.00
IUUC-Cho-024387	Choloepus hoffmanni	90.47	0.00e+00	1797.00
IUUC-Cin-025709	Ciona intestinalis	52.20	0.00e+00	2043.00
IUUC-Csv-026336	Ciona savignyi	34.68	0.00e+00	1412.00
IUUC-Dre-027717	Danio rerio	79.81	0.00e+00	3477.00
IUUC-Dno-029296	Dasypus novemcinctus	80.73	0.00e+00	6985.00
IUUC-Dor-030979	Dipodomys ordii	82.74	0.00e+00	1556.00
IUUC-Dme-032171	Drosophila melanogaster	55.71	0.00e+00	1359.00
IUUC-Ete-032687	Echinops telfairi	65.33	0.00e+00	1912.00
IUUC-Eca-034046	Equus caballus	79.99	0.00e+00	6832.00
IUUC-Eeu-034859	Erinaceus europaeus	88.44	0.00e+00	1805.00
IUUC-Fca-036262	Felis catus	80.49	0.00e+00	6885.00
IUUC-Fal-037562	Ficedula albicollis	83.39	0.00e+00	7169.00
IUUC-Gmo-039054	Gadus morhua	87.44	0.00e+00	1094.00
IUUC-Gga-040359	Gallus gallus	83.74	0.00e+00	7219.00
IUUC-Gac-041879	Gasterosteus aculeatus	83.33	0.00e+00	834.00
IUUC-Ggo-044692	Gorilla gorilla	88.87	0.00e+00	3903.00
IUUC-Hsa-045995	Homo sapiens	80.49	0.00e+00	6883.00
IUUC-Hvu-047529	Hordeum vulgare	35.65	1.00e-49	192.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	80.29	0.00e+00	2024.00
IUUC-Lch-049808	Latimeria chalumnae	82.01	0.00e+00	3054.00
IUUC-Lpe-051482	Leersia perrieri	34.46	6.00e-47	182.00
IUUC-Loc-052685	Lepisosteus oculatus	78.89	0.00e+00	6612.00
IUUC-Laf-053372	Loxodonta africana	81.62	0.00e+00	6943.00
IUUC-Mcc-054693	Macaca mulatta	80.38	0.00e+00	6876.00
IUUC-Meu-056660	Macropus eugenii	89.65	0.00e+00	1724.00
IUUC-Mga-059371	Meleagris gallopavo	86.11	0.00e+00	6593.00
IUUC-Mmr-060787	Microcebus murinus	80.45	0.00e+00	6912.00
IUUC-Mdo-062518	Monodelphis domestica	83.57	0.00e+00	7039.00
IUUC-Mmu-063690	Mus musculus	79.90	0.00e+00	6804.00
IUUC-Mpu-066478	Mustela putorius furo	80.04	0.00e+00	6822.00
IUUC-Mlu-067596	Myotis lucifugus	82.65	0.00e+00	3927.00
IUUC-Nle-069445	Nomascus leucogenys	75.78	0.00e+00	1701.00
IUUC-Opr-070990	Ochotona princeps	79.16	0.00e+00	2615.00
IUUC-Ont-072285	Oreochromis niloticus	77.69	0.00e+00	6424.00
IUUC-Oan-072721	Ornithorhynchus anatinus	85.29	0.00e+00	3151.00
IUUC-Ocu-074273	Oryctolagus cuniculus	81.66	0.00e+00	6964.00
IUUC-Oba-075573	Oryza barthii	33.68	1.00e-45	178.00
IUUC-Obr-076107	Oryza brachyantha	33.77	3.00e-50	193.00
IUUC-Ogl-077193	Oryza glaberrima	33.68	1.00e-45	178.00
IUUC-Ogu-078817	Oryza glumaepatula	33.68	1.00e-45	178.00
IUUC-Oin-079609	Oryza indica	32.75	2.00e-49	191.00
IUUC-Olo-080629	Oryza longistaminata	33.68	1.00e-45	178.00
IUUC-Ome-081686	Oryza meridionalis	33.68	3.00e-46	180.00
IUUC-Opu-084137	Oryza punctata	33.94	2.00e-46	181.00
IUUC-Oru-085013	Oryza rufipogon	33.68	1.00e-45	178.00
IUUC-Osa-085597	Oryza sativa	33.68	1.00e-45	178.00
IUUC-Ola-087346	Oryzias latipes	79.97	0.00e+00	989.00
IUUC-Oga-088742	Otolemur garnettii	81.04	0.00e+00	6874.00
IUUC-Oar-090093	Ovis aries	79.86	0.00e+00	6815.00
IUUC-Ptr-091034	Pan troglodytes	80.07	0.00e+00	4927.00
IUUC-Pan-092783	Papio anubis	79.26	0.00e+00	6771.00
IUUC-Psi-094027	Pelodiscus sinensis	83.34	0.00e+00	7107.00
IUUC-Pfo-096208	Poecilia formosa	79.34	0.00e+00	4472.00
IUUC-Pab-097681	Pongo abelii	78.98	0.00e+00	2155.00
IUUC-Pop-099121	Populus trichocarpa	34.93	2.00e-51	197.00
IUUC-Pca-100705	Procavia capensis	92.58	0.00e+00	1146.00
IUUC-Pva-103147	Pteropus vampyrus	70.70	0.00e+00	1995.00
IUUC-Rno-105458	Rattus norvegicus	79.84	0.00e+00	6790.00
IUUC-Smo-108827	Selaginella moellendorffii	34.39	3.00e-50	193.00
IUUC-Sit-109917	Setaria italica	36.47	1.00e-48	188.00
IUUC-Sly-110961	Solanum lycopersicum	35.33	1.00e-53	205.00
IUUC-Stu-112166	Solanum tuberosum	32.47	1.00e-45	178.00
IUUC-Sar-113532	Sorex araneus	80.67	0.00e+00	1700.00
IUUC-Sbi-114352	Sorghum bicolor	32.39	6.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	75.84	0.00e+00	2430.00
IUUC-Tgu-116789	Taeniopygia guttata	83.27	0.00e+00	7195.00
IUUC-Tru-118129	Takifugu rubripes	80.48	0.00e+00	5659.00
IUUC-Tsy-119302	Tarsius syrichta	79.80	0.00e+00	1177.00
IUUC-Tni-120374	Tetraodon nigroviridis	79.77	0.00e+00	5534.00
IUUC-Tca-121094	Theobroma cacao	35.59	9.00e-55	208.00
IUUC-Tae-124157	Triticum aestivum	32.29	6.00e-50	192.00
IUUC-Tur-126300	Triticum urartu	35.65	4.00e-50	193.00
IUUC-Tbe-128137	Tupaia belangeri	77.81	0.00e+00	1007.00
IUUC-Ttr-128273	Tursiops truncatus	79.89	0.00e+00	2421.00
IUUC-Vpa-130471	Vicugna pacos	78.07	0.00e+00	1348.00
IUUC-Xtr-132185	Xenopus tropicalis	78.71	0.00e+00	6655.00
IUUC-Xma-133233	Xiphophorus maculatus	80.49	0.00e+00	5618.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence