iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.70e-28	95.4	100	131
UBD/Beta-Prp	2.30e-48	164.9	11	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH  sv+ l+f ++  ++vsGs+D t+++WD+
   Q: 100  GHMKSVRTLDFnPSgEYVVSGSNDTTVRLWDV 131
           8999********666****************8 PP

UBD/Beta-Prp

   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           ++ +k+h+++v+sl++ ++g +lv+G++dr +++w + +++c+   l+gh++++ cv++  ++n + s+ + +++r Wdl+++k+  tl g h +sv+
   Q: 11   IYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFM-SLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNG-HMKSVR 106
           56677888888888888888888888888888888888888888.8888888888888888888888888888888888888888888887.888888 PP
   S: 185  slsfdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
            l+f+++g+++vsgs+d+tv+lwd+q +++c++ ++gh + v+sv+fsp++ +++s++ +gsi iWd+r+++ 
   Q: 107  TLDFNPSGEYVVSGSNDTTVRLWDVQnENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQ 179
           8888888888888888888888888877778888888888888888888888888888888888888877654 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

MALPRKLISK IYDIKAHDSR VTSLDLGETG RVLVTGGEDR NVNLWAIGQN ECFMSLTGHN 60
RSIDCVRFAY KDNFVYSADD IGIIRRWDLN SQKIYSTLNG HMKSVRTLDF NPSGEYVVSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCATTTAG TCTATTTAAA TATTTAATTT AATACTTTTG TAAACCGTTT TACAGCTTCA 60
GGGCTGTAAA TAATTTAGTA AAATATCAAT TAATTTTTTT TCACATTATC TGTTATTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0046843--P:dorsal appendage formation
GO:0051013--P:microtubule severing
GO:0007017--P:microtubule-based process
GO:0007067--P:mitotic nuclear division

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	35.44	5.00e-53	202.00
IUUC-Aml-002187	Ailuropoda melanoleuca	40.78	9.00e-60	224.00
IUUC-Atr-002899	Amborella trichopoda	37.19	5.00e-59	221.00
IUUC-Apl-003305	Anas platyrhynchos	38.61	2.00e-62	233.00
IUUC-Aca-004635	Anolis carolinensis	39.53	7.00e-56	211.00
IUUC-Aly-006226	Arabidopsis lyrata	37.75	7.00e-59	221.00
IUUC-Ath-007323	Arabidopsis thaliana	37.75	1.00e-58	221.00
IUUC-Bta-012527	Bos taurus	40.45	5.00e-63	234.00
IUUC-Bdi-014652	Brachypodium distachyon	38.06	8.00e-60	224.00
IUUC-Bol-015242	Brassica oleracea	36.93	7.00e-58	218.00
IUUC-Bra-017390	Brassica rapa	37.09	9.00e-58	218.00
IUUC-Cja-019706	Callithrix jacchus	39.81	2.00e-62	233.00
IUUC-Cfa-020139	Canis familiaris	42.98	3.00e-50	192.00
IUUC-Cpo-021710	Cavia porcellus	39.48	3.00e-62	232.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	32.48	3.00e-46	179.00
IUUC-Csa-023546	Chlorocebus sabaeus	40.69	2.00e-61	229.00
IUUC-Cin-025156	Ciona intestinalis	36.64	1.00e-52	200.00
IUUC-Csv-025962	Ciona savignyi	36.99	8.00e-51	192.00
IUUC-Dre-028215	Danio rerio	40.45	4.00e-67	248.00
IUUC-Dno-029314	Dasypus novemcinctus	39.81	6.00e-62	231.00
IUUC-Dor-030482	Dipodomys ordii	39.81	8.00e-63	234.00
IUUC-Eca-034143	Equus caballus	39.81	5.00e-60	224.00
IUUC-Fca-035924	Felis catus	40.13	8.00e-63	234.00
IUUC-Fal-037387	Ficedula albicollis	38.76	6.00e-62	231.00
IUUC-Gmo-038692	Gadus morhua	38.53	3.00e-67	248.00
IUUC-Gga-040597	Gallus gallus	38.92	4.00e-62	231.00
IUUC-Gac-042004	Gasterosteus aculeatus	37.75	3.00e-63	235.00
IUUC-Gma-044134	Glycine max	35.90	6.00e-56	211.00
IUUC-Ggo-044761	Gorilla gorilla	39.81	5.00e-62	231.00
IUUC-Hsa-045698	Homo sapiens	39.81	2.00e-62	232.00
IUUC-Hvu-047649	Hordeum vulgare	36.28	5.00e-61	228.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	39.81	1.00e-62	233.00
IUUC-Lch-049674	Latimeria chalumnae	40.86	1.00e-63	237.00
IUUC-Lpe-051554	Leersia perrieri	38.87	3.00e-61	229.00
IUUC-Loc-052623	Lepisosteus oculatus	42.29	7.00e-66	244.00
IUUC-Laf-054587	Loxodonta africana	40.13	2.00e-62	233.00
IUUC-Mcc-055851	Macaca mulatta	39.81	5.00e-62	231.00
IUUC-Meu-056704	Macropus eugenii	40.13	3.00e-64	238.00
IUUC-Mtr-058053	Medicago truncatula	36.47	5.00e-60	225.00
IUUC-Mga-059608	Meleagris gallopavo	37.27	5.00e-61	228.00
IUUC-Mmr-061154	Microcebus murinus	39.81	2.00e-62	233.00
IUUC-Mdo-062365	Monodelphis domestica	40.13	5.00e-64	238.00
IUUC-Mmu-063754	Mus musculus	39.81	1.00e-62	233.00
IUUC-Mac-065100	Musa acuminata	37.29	2.00e-58	219.00
IUUC-Mpu-066245	Mustela putorius furo	40.13	7.00e-63	234.00
IUUC-Mlu-067692	Myotis lucifugus	40.60	1.00e-62	233.00
IUUC-Nle-070051	Nomascus leucogenys	39.48	2.00e-61	229.00
IUUC-Opr-070855	Ochotona princeps	40.13	8.00e-63	234.00
IUUC-Ont-071883	Oreochromis niloticus	37.75	1.00e-64	240.00
IUUC-Oan-073293	Ornithorhynchus anatinus	41.72	2.00e-64	239.00
IUUC-Ocu-074644	Oryctolagus cuniculus	39.81	7.00e-63	234.00
IUUC-Oba-075448	Oryza barthii	36.78	6.00e-60	225.00
IUUC-Obr-076385	Oryza brachyantha	38.21	1.00e-59	224.00
IUUC-Ogl-077427	Oryza glaberrima	37.87	3.00e-59	223.00
IUUC-Ogu-078062	Oryza glumaepatula	36.84	2.00e-57	216.00
IUUC-Oin-079811	Oryza indica	38.31	1.00e-58	220.00
IUUC-Olo-080245	Oryza longistaminata	38.31	2.00e-58	220.00
IUUC-Ome-081239	Oryza meridionalis	37.67	1.00e-58	220.00
IUUC-Oni-082640	Oryza nivara	36.78	6.00e-60	225.00
IUUC-Opu-083748	Oryza punctata	38.21	1.00e-59	224.00
IUUC-Oru-084609	Oryza rufipogon	36.78	6.00e-60	225.00
IUUC-Osa-085801	Oryza sativa	36.43	1.00e-57	217.00
IUUC-Ola-087483	Oryzias latipes	39.80	2.00e-66	246.00
IUUC-Oga-087964	Otolemur garnettii	39.81	2.00e-62	233.00
IUUC-Oar-089483	Ovis aries	39.48	4.00e-60	225.00
IUUC-Ptr-091387	Pan troglodytes	39.81	2.00e-62	232.00
IUUC-Pan-092623	Papio anubis	39.81	5.00e-62	231.00
IUUC-Psi-093830	Pelodiscus sinensis	40.14	8.00e-61	227.00
IUUC-Ppa-095379	Physcomitrella patens	36.13	2.00e-54	206.00
IUUC-Pfo-096755	Poecilia formosa	39.74	1.00e-66	246.00
IUUC-Pab-097564	Pongo abelii	40.32	8.00e-62	230.00
IUUC-Pop-099149	Populus trichocarpa	37.76	3.00e-60	225.00
IUUC-Pca-100357	Procavia capensis	43.46	4.00e-46	178.00
IUUC-Ppe-101237	Prunus persica	37.70	1.00e-59	223.00
IUUC-Pva-102397	Pteropus vampyrus	37.42	3.00e-54	206.00
IUUC-Rno-105349	Rattus norvegicus	39.81	1.00e-62	233.00
IUUC-Smo-109409	Selaginella moellendorffii	37.29	1.00e-56	213.00
IUUC-Sit-110360	Setaria italica	38.71	1.00e-61	230.00
IUUC-Sly-111307	Solanum lycopersicum	36.54	1.00e-55	211.00
IUUC-Stu-112462	Solanum tuberosum	36.95	8.00e-55	207.00
IUUC-Sar-112953	Sorex araneus	33.05	9.00e-33	134.00
IUUC-Sbi-114389	Sorghum bicolor	36.08	5.00e-58	218.00
IUUC-Tgu-117461	Taeniopygia guttata	34.63	2.00e-62	232.00
IUUC-Tru-117865	Takifugu rubripes	36.50	4.00e-66	245.00
IUUC-Tsy-119036	Tarsius syrichta	46.46	3.00e-27	115.00
IUUC-Tni-120903	Tetraodon nigroviridis	36.20	6.00e-64	238.00
IUUC-Tca-121185	Theobroma cacao	37.38	5.00e-59	222.00
IUUC-Tae-125263	Triticum aestivum	36.28	4.00e-61	229.00
IUUC-Tur-126181	Triticum urartu	37.19	4.00e-58	219.00
IUUC-Ttr-128172	Tursiops truncatus	39.81	1.00e-62	233.00
IUUC-Vvi-131489	Vitis vinifera	37.21	4.00e-60	225.00
IUUC-Xtr-132915	Xenopus tropicalis	38.64	2.00e-57	216.00
IUUC-Xma-134133	Xiphophorus maculatus	39.74	1.00e-65	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence