iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117461

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

ABQF01124031

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000004876.1	ENSTGUT00000005093.1	ENSTGUP00000005043.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-44	147.3	145	181
UBD/Beta-Prp	6.40e-66	222.4	9	229

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gHt+ v+cl+f +d + ++s++dD+t+k+WDl+ g+l
   Q: 145  GHTEAVRCLRFsPDgKWVASAADDHTVKLWDLTAGKL 181
           8***********999******************9986 PP

UBD/Beta-Prp

   S: 41   tgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqc 128
           t ++l+++  h++ v++v + + +  +l+tg++D  +++w++s++ c+++l+gh+  + sl+++p+ + +v+Gs+   irvwdle  ++
   Q: 9    TAWKLQEIMAHSSNVSSVVLGKGSGrMLATGGDDCRVNIWSVSKPNCIMSLTGHTTPIESLQVNPNEKLIVAGSRSGSIRVWDLEAAKV 97
           4455789999******9999766555*************************************************************** PP
   S: 129  leetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrt 217
           l+ tl gh++ ++++++hp+g+ ++sGslD+ ++lWd++++ ++ t++g ht++v++l f+++gk ++s+++d tvklwdl +g+ + +
   Q: 98   LR-TLPGHKANICSLHFHPFGSFVASGSLDTNIKLWDVRRKGCIFTFKG-HTEAVRCLRFSPDGKWVASAADDHTVKLWDLTAGKLMFE 184
           **.*********************************************9.*************************************** PP
   S: 218  lnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
           ++ght +v++v+f+pn+ +l+sgssD+++r+Wdl++ +++++++ 
   Q: 185  FTGHTGPVNVVEFHPNEYLLASGSSDRTVRFWDLEKFQVVSCIEE 229
           **************************************9999876 PP

Organism

Taeniopygia guttata

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

MAVAVTTKTA WKLQEIMAHS SNVSSVVLGK GSGRMLATGG DDCRVNIWSV SKPNCIMSLT 60
GHTTPIESLQ VNPNEKLIVA GSRSGSIRVW DLEAAKVLRT LPGHKANICS LHFHPFGSFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGGCGGG GGTCCCGCTC CGGTACTGCC GGGCCCCGCC GCCACCAGCC TCCAGGCGAT 60
CGCCCTCGCC CCGGCCAGCG CTCCCGTCCC GTGATGTTCG TCAGCGGTGA GGCCTCGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000873	Aegilops tauschii	47.42	1.00e-84	307.00
IUUC-Aml-002187	Ailuropoda melanoleuca	72.96	0.00e+00	914.00
IUUC-Atr-002899	Amborella trichopoda	54.45	5.00e-103	368.00
IUUC-Apl-003305	Anas platyrhynchos	85.03	0.00e+00	1107.00
IUUC-Aca-004635	Anolis carolinensis	79.79	0.00e+00	977.00
IUUC-Aly-005711	Arabidopsis lyrata	52.82	5.00e-104	371.00
IUUC-Ath-007606	Arabidopsis thaliana	52.82	7.00e-104	371.00
IUUC-Ame-010870	Astyanax mexicanus	57.80	7.00e-98	349.00
IUUC-Bta-012527	Bos taurus	77.78	0.00e+00	993.00
IUUC-Bdi-014652	Brachypodium distachyon	52.15	8.00e-104	371.00
IUUC-Bol-015242	Brassica oleracea	51.50	1.00e-102	367.00
IUUC-Bra-017390	Brassica rapa	51.83	4.00e-103	369.00
IUUC-Cja-019706	Callithrix jacchus	75.94	0.00e+00	929.00
IUUC-Cfa-020139	Canis familiaris	63.36	0.00e+00	629.00
IUUC-Cpo-021710	Cavia porcellus	77.66	0.00e+00	979.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	43.46	3.00e-72	266.00
IUUC-Csa-023546	Chlorocebus sabaeus	76.28	0.00e+00	907.00
IUUC-Cin-025156	Ciona intestinalis	41.31	1.00e-151	529.00
IUUC-Csv-025962	Ciona savignyi	48.14	6.00e-89	320.00
IUUC-Dre-028215	Danio rerio	61.84	0.00e+00	836.00
IUUC-Dno-029314	Dasypus novemcinctus	77.40	0.00e+00	941.00
IUUC-Dor-030482	Dipodomys ordii	77.48	0.00e+00	1001.00
IUUC-Dme-032188	Drosophila melanogaster	34.63	1.00e-59	224.00
IUUC-Eca-034143	Equus caballus	77.36	0.00e+00	981.00
IUUC-Fca-035924	Felis catus	76.43	0.00e+00	964.00
IUUC-Fal-037387	Ficedula albicollis	95.64	0.00e+00	1238.00
IUUC-Gmo-038692	Gadus morhua	57.98	0.00e+00	746.00
IUUC-Gga-040597	Gallus gallus	84.81	0.00e+00	1123.00
IUUC-Gac-042004	Gasterosteus aculeatus	61.46	0.00e+00	827.00
IUUC-Gma-044134	Glycine max	53.16	2.00e-102	366.00
IUUC-Ggo-044761	Gorilla gorilla	76.13	0.00e+00	925.00
IUUC-Hsa-045698	Homo sapiens	76.43	0.00e+00	944.00
IUUC-Hvu-047649	Hordeum vulgare	51.49	4.00e-103	369.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	77.48	0.00e+00	956.00
IUUC-Lch-049674	Latimeria chalumnae	66.33	0.00e+00	928.00
IUUC-Lpe-051554	Leersia perrieri	52.81	1.00e-105	377.00
IUUC-Loc-052623	Lepisosteus oculatus	65.61	0.00e+00	882.00
IUUC-Laf-054587	Loxodonta africana	77.96	0.00e+00	989.00
IUUC-Mcc-055851	Macaca mulatta	76.13	0.00e+00	925.00
IUUC-Meu-056704	Macropus eugenii	79.25	0.00e+00	1054.00
IUUC-Mtr-058053	Medicago truncatula	52.82	3.00e-105	375.00
IUUC-Mga-059608	Meleagris gallopavo	84.83	0.00e+00	1110.00
IUUC-Mmr-061154	Microcebus murinus	75.07	0.00e+00	946.00
IUUC-Mdo-062365	Monodelphis domestica	75.79	0.00e+00	999.00
IUUC-Mmu-063754	Mus musculus	78.26	0.00e+00	966.00
IUUC-Mac-064667	Musa acuminata	50.64	8.00e-101	360.00
IUUC-Mpu-066245	Mustela putorius furo	76.28	0.00e+00	933.00
IUUC-Mlu-067692	Myotis lucifugus	77.79	0.00e+00	969.00
IUUC-Nle-070051	Nomascus leucogenys	75.67	0.00e+00	917.00
IUUC-Opr-070855	Ochotona princeps	77.36	0.00e+00	967.00
IUUC-Ont-071883	Oreochromis niloticus	57.80	0.00e+00	815.00
IUUC-Oan-073293	Ornithorhynchus anatinus	78.14	0.00e+00	916.00
IUUC-Ocu-074644	Oryctolagus cuniculus	78.56	0.00e+00	982.00
IUUC-Oba-075448	Oryza barthii	53.47	2.00e-106	380.00
IUUC-Obr-076385	Oryza brachyantha	52.48	2.00e-105	377.00
IUUC-Ogl-077427	Oryza glaberrima	53.47	8.00e-107	381.00
IUUC-Ogu-079022	Oryza glumaepatula	48.87	3.00e-96	345.00
IUUC-Oin-079811	Oryza indica	51.11	1.00e-103	370.00
IUUC-Olo-080245	Oryza longistaminata	51.11	1.00e-103	370.00
IUUC-Ome-081239	Oryza meridionalis	53.58	6.00e-103	368.00
IUUC-Oni-082640	Oryza nivara	53.47	2.00e-106	380.00
IUUC-Opu-083748	Oryza punctata	53.14	4.00e-106	379.00
IUUC-Oru-084609	Oryza rufipogon	53.47	2.00e-106	380.00
IUUC-Osa-086267	Oryza sativa	48.87	2.00e-96	346.00
IUUC-Ola-087483	Oryzias latipes	55.09	0.00e+00	632.00
IUUC-Oga-087964	Otolemur garnettii	77.81	0.00e+00	992.00
IUUC-Oar-089483	Ovis aries	76.46	0.00e+00	945.00
IUUC-Ptr-091387	Pan troglodytes	76.58	0.00e+00	946.00
IUUC-Pan-092623	Papio anubis	76.13	0.00e+00	925.00
IUUC-Psi-093830	Pelodiscus sinensis	85.41	0.00e+00	1093.00
IUUC-Pma-094135	Petromyzon marinus	41.35	7.00e-38	149.00
IUUC-Ppa-095379	Physcomitrella patens	55.14	3.00e-98	352.00
IUUC-Pfo-096755	Poecilia formosa	58.00	0.00e+00	812.00
IUUC-Pab-097564	Pongo abelii	73.40	0.00e+00	802.00
IUUC-Pop-099149	Populus trichocarpa	54.15	2.00e-107	382.00
IUUC-Pca-100357	Procavia capensis	82.86	5.00e-109	387.00
IUUC-Ppe-101237	Prunus persica	53.49	2.00e-105	376.00
IUUC-Pva-102397	Pteropus vampyrus	73.87	0.00e+00	907.00
IUUC-Rno-105349	Rattus norvegicus	78.38	0.00e+00	1004.00
IUUC-Smo-109558	Selaginella moellendorffii	34.51	4.00e-107	381.00
IUUC-Sit-110360	Setaria italica	53.47	3.00e-106	379.00
IUUC-Sly-111307	Solanum lycopersicum	53.67	3.00e-102	365.00
IUUC-Stu-112462	Solanum tuberosum	52.74	5.00e-98	351.00
IUUC-Sar-112953	Sorex araneus	68.42	4.00e-90	325.00
IUUC-Sbi-114389	Sorghum bicolor	45.21	5.00e-95	342.00
IUUC-Ssc-115949	Sus scrofa	77.14	0.00e+00	727.00
IUUC-Tru-117865	Takifugu rubripes	59.13	0.00e+00	812.00
IUUC-Tsy-119036	Tarsius syrichta	63.49	2.00e-62	233.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.90	0.00e+00	785.00
IUUC-Tca-121185	Theobroma cacao	53.16	1.00e-104	374.00
IUUC-Tae-125307	Triticum aestivum	52.15	6.00e-104	371.00
IUUC-Tur-126181	Triticum urartu	44.25	3.00e-93	336.00
IUUC-Tbe-127518	Tupaia belangeri	66.59	3.00e-154	538.00
IUUC-Ttr-128172	Tursiops truncatus	77.03	0.00e+00	959.00
IUUC-Vvi-131489	Vitis vinifera	54.49	4.00e-107	382.00
IUUC-Xtr-132915	Xenopus tropicalis	69.76	0.00e+00	920.00
IUUC-Xma-134133	Xiphophorus maculatus	57.43	0.00e+00	799.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence