iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.70e-10	40.4	46	108

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.......elegkrGlfPenFvek 61
           +++ +l+dyea + ++L++++Gd+++v+  ++  egW+ + +         ++ +G +P+n+v++
   Q: 46   QYFVALFDYEARTAEDLSFHAGDKLQVL--DTSHEGWWLARHlekkgpgLGQQLQGYIPSNYVAE 108
           6889************************..88999***99889999998888889*******975 PP

Organism

Rattus norvegicus

Functional Description
(View)

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).

Protein Sequence
(Fasta)

MGSVCMRLWA YLQPFLPCWS QEADKSVVIE NPGAYCPPEA NRSQGQYFVA LFDYEARTAE 60
DLSFHAGDKL QVLDTSHEGW WLARHLEKKG PGLGQQLQGY IPSNYVAEDR SLQAEPWFFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCTGCAGG TTTGAAGCTG GGTGAGAGCA GCTGCAGCAG GCCAGGCTGG GAGCTTTCGC 60
CTGGAGTTAG TCTCTCCGTA ACTTTTTCCT GGGACAGAGG GAGAGGTGGC TGTTCTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

rno:79209

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	26.72	9.00e-23	102.00
IUUC-Apl-003394	Anas platyrhynchos	67.50	0.00e+00	721.00
IUUC-Aca-004553	Anolis carolinensis	68.18	0.00e+00	731.00
IUUC-Cja-019885	Callithrix jacchus	90.10	0.00e+00	959.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	30.64	4.00e-23	102.00
IUUC-Cin-025605	Ciona intestinalis	55.46	3.00e-152	531.00
IUUC-Dre-028274	Danio rerio	63.83	6.00e-176	610.00
IUUC-Dno-029689	Dasypus novemcinctus	87.62	0.00e+00	929.00
IUUC-Dme-031976	Drosophila melanogaster	62.04	6.00e-173	600.00
IUUC-Eeu-034770	Erinaceus europaeus	72.87	0.00e+00	661.00
IUUC-Fal-036892	Ficedula albicollis	73.29	0.00e+00	699.00
IUUC-Gga-041072	Gallus gallus	68.32	0.00e+00	707.00
IUUC-Hvu-047855	Hordeum vulgare	27.86	1.00e-23	105.00
IUUC-Loc-052913	Lepisosteus oculatus	64.67	4.00e-180	624.00
IUUC-Mga-059456	Meleagris gallopavo	68.15	0.00e+00	704.00
IUUC-Mmr-061480	Microcebus murinus	87.53	0.00e+00	903.00
IUUC-Mlu-067167	Myotis lucifugus	82.02	0.00e+00	864.00
IUUC-Nle-069786	Nomascus leucogenys	89.11	0.00e+00	951.00
IUUC-Ont-072417	Oreochromis niloticus	61.06	0.00e+00	634.00
IUUC-Ogl-077331	Oryza glaberrima	30.05	6.00e-24	106.00
IUUC-Ogu-078962	Oryza glumaepatula	30.05	7.00e-24	105.00
IUUC-Oin-079172	Oryza indica	30.05	6.00e-24	106.00
IUUC-Olo-080286	Oryza longistaminata	30.05	6.00e-24	106.00
IUUC-Ome-081400	Oryza meridionalis	30.05	6.00e-24	106.00
IUUC-Oni-082734	Oryza nivara	30.05	1.00e-23	105.00
IUUC-Opu-083538	Oryza punctata	30.54	1.00e-23	105.00
IUUC-Oru-084741	Oryza rufipogon	30.05	5.00e-24	106.00
IUUC-Osa-085779	Oryza sativa	30.05	6.00e-24	106.00
IUUC-Ola-086419	Oryzias latipes	60.16	0.00e+00	627.00
IUUC-Pan-092732	Papio anubis	89.31	0.00e+00	949.00
IUUC-Psi-093899	Pelodiscus sinensis	70.90	0.00e+00	747.00
IUUC-Pma-094230	Petromyzon marinus	62.61	4.00e-172	597.00
IUUC-Pfo-096035	Poecilia formosa	59.96	4.00e-173	600.00
IUUC-Pva-103122	Pteropus vampyrus	67.26	0.00e+00	673.00
IUUC-Sit-109712	Setaria italica	26.54	4.00e-23	103.00
IUUC-Tgu-116491	Taeniopygia guttata	73.99	0.00e+00	704.00
IUUC-Tru-117795	Takifugu rubripes	54.82	5.00e-163	567.00
IUUC-Tni-120512	Tetraodon nigroviridis	60.19	0.00e+00	630.00
IUUC-Tae-123192	Triticum aestivum	26.72	5.00e-23	103.00
IUUC-Ttr-128817	Tursiops truncatus	90.51	0.00e+00	949.00
IUUC-Vpa-130389	Vicugna pacos	81.42	0.00e+00	840.00
IUUC-Xtr-132360	Xenopus tropicalis	58.49	0.00e+00	647.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence