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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046081
Ensembl Protein ID ENSP00000437550.1
UniProt Accession O95835; Q6PKD0; LATS1_HUMAN
Genbank Protein ID AAD16882.1; AAD50272.1; AAH02767.1
Protein Name Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase
Genbank Nucleotide ID AF104413; AF164041; BC002767
Gene Name LATS1; WARTS
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131023.12 ENST00000543571.5 ENSP00000437550.1
ENSG00000131023.12 ENST00000441107.5 ENSP00000403815.1
ENSG00000131023.12 ENST00000392273.7 ENSP00000444678.1
ENSG00000131023.12 ENST00000458696.2 ENSP00000441265.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 21233212; 24107629; 25026211; 26598551
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 2.10e-07 32.5 102 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++l+ l++ GFd++ ++qaL+ + n ++eaA+e++ 
   Q: 102  NPQMLQDLQAAGFDEDMVIQALQKTnNRSIEAAIEFIS 139
           789*********************99*********975 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).
 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).
Protein Sequence
(Fasta)
MKRSEKPEGY RQMRPKTFPA SNYTVSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMSTE 60
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETNSSRSTSE VNPQMLQDLQ AAGFDEDMVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046081|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGACGCTCA CGAACGATCA GAGCTGCGGG CGACGCAACG AAGCCCGGAG GCCGCAGGCT 60
GCGCGCTCCC TCGCAGCAGC CGGGCGGGCA AAAGCCCCCA GTCCTCGGCC CCCGCGCAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046081|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor
Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS51285--AGC_KINASE_CTER
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0030331--F:estrogen receptor binding
GO:0000287--F:magnesium ion binding
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051301--P:cell division
GO:0051220--P:cytoplasmic sequestering of protein
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0030216--P:keratinocyte differentiation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0043065--P:positive regulation of apoptotic process
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0006468--P:protein phosphorylation
GO:0030833--P:regulation of actin filament polymerization
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0046620--P:regulation of organ growth
GO:0043254--P:regulation of protein complex assembly
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000819--P:sister chromatid segregation
KEGG hsa:9113
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001895 Ailuropoda melanoleuca 96.20 0.00e+00 1998.00
IUUC-Apl-003278 Anas platyrhynchos 83.93 0.00e+00 1810.00
IUUC-Aca-005319 Anolis carolinensis 82.04 0.00e+00 1740.00
IUUC-Ame-011324 Astyanax mexicanus 84.91 0.00e+00 942.00
IUUC-Bta-013438 Bos taurus 94.96 0.00e+00 1942.00
IUUC-Cel-018517 Caenorhabditis elegans 50.32 3.00e-129 456.00
IUUC-Cja-019072 Callithrix jacchus 98.05 0.00e+00 2079.00
IUUC-Cfa-021267 Canis familiaris 96.28 0.00e+00 2015.00
IUUC-Cpo-021496 Cavia porcellus 91.08 0.00e+00 1674.00
IUUC-Csa-023255 Chlorocebus sabaeus 98.67 0.00e+00 2080.00
IUUC-Cho-024461 Choloepus hoffmanni 98.40 0.00e+00 788.00
IUUC-Cin-025264 Ciona intestinalis 63.68 5.00e-141 494.00
IUUC-Dre-028034 Danio rerio 82.14 0.00e+00 928.00
IUUC-Dno-029888 Dasypus novemcinctus 92.75 0.00e+00 1998.00
IUUC-Dor-030144 Dipodomys ordii 85.59 0.00e+00 1690.00
IUUC-Dme-031656 Drosophila melanogaster 73.66 0.00e+00 659.00
IUUC-Ete-032813 Echinops telfairi 94.55 0.00e+00 1230.00
IUUC-Eca-033781 Equus caballus 96.02 0.00e+00 1974.00
IUUC-Eeu-035007 Erinaceus europaeus 92.75 0.00e+00 1989.00
IUUC-Fca-036142 Felis catus 91.77 0.00e+00 1895.00
IUUC-Fal-036626 Ficedula albicollis 83.32 0.00e+00 1809.00
IUUC-Gmo-038688 Gadus morhua 85.75 0.00e+00 781.00
IUUC-Gga-040553 Gallus gallus 84.27 0.00e+00 1815.00
IUUC-Gac-042031 Gasterosteus aculeatus 64.08 0.00e+00 1270.00
IUUC-Ggo-045242 Gorilla gorilla 99.56 0.00e+00 2093.00
IUUC-Itr-048668 Ictidomys tridecemlineatus 95.97 0.00e+00 1727.00
IUUC-Lch-049425 Latimeria chalumnae 78.33 0.00e+00 1706.00
IUUC-Loc-052418 Lepisosteus oculatus 67.10 0.00e+00 1368.00
IUUC-Laf-053710 Loxodonta africana 93.90 0.00e+00 1969.00
IUUC-Mcc-055079 Macaca mulatta 98.85 0.00e+00 2078.00
IUUC-Mga-059713 Meleagris gallopavo 83.60 0.00e+00 1813.00
IUUC-Mmr-061728 Microcebus murinus 96.99 0.00e+00 2033.00
IUUC-Mdo-061942 Monodelphis domestica 87.43 0.00e+00 1834.00
IUUC-Mmu-063504 Mus musculus 93.10 0.00e+00 1914.00
IUUC-Mpu-066034 Mustela putorius furo 95.75 0.00e+00 2008.00
IUUC-Mlu-067986 Myotis lucifugus 94.34 0.00e+00 1975.00
IUUC-Nle-069202 Nomascus leucogenys 99.20 0.00e+00 2088.00
IUUC-Opr-070801 Ochotona princeps 95.35 0.00e+00 1291.00
IUUC-Ont-072487 Oreochromis niloticus 60.83 0.00e+00 1239.00
IUUC-Oan-073128 Ornithorhynchus anatinus 86.87 0.00e+00 1594.00
IUUC-Ocu-073998 Oryctolagus cuniculus 96.30 0.00e+00 1442.00
IUUC-Ola-086858 Oryzias latipes 60.14 0.00e+00 1192.00
IUUC-Oga-088874 Otolemur garnettii 94.62 0.00e+00 1948.00
IUUC-Oar-089236 Ovis aries 94.87 0.00e+00 1943.00
IUUC-Ptr-091425 Pan troglodytes 99.65 0.00e+00 2096.00
IUUC-Pan-091851 Papio anubis 98.94 0.00e+00 2080.00
IUUC-Psi-093825 Pelodiscus sinensis 85.17 0.00e+00 1513.00
IUUC-Pfo-096326 Poecilia formosa 61.43 0.00e+00 1190.00
IUUC-Pab-097815 Pongo abelii 99.56 0.00e+00 2094.00
IUUC-Pva-102836 Pteropus vampyrus 94.60 0.00e+00 1892.00
IUUC-Ptt-103762 Puccinia triticina 38.90 1.00e-93 337.00
IUUC-Rno-106053 Rattus norvegicus 93.54 0.00e+00 1972.00
IUUC-Sha-106843 Sarcophilus harrisii 88.55 0.00e+00 1871.00
IUUC-Sar-113649 Sorex araneus 93.29 0.00e+00 1558.00
IUUC-Ssc-115486 Sus scrofa 97.38 0.00e+00 862.00
IUUC-Tgu-116903 Taeniopygia guttata 83.32 0.00e+00 1788.00
IUUC-Tru-118760 Takifugu rubripes 64.25 0.00e+00 1290.00
IUUC-Tsy-119361 Tarsius syrichta 95.86 0.00e+00 1722.00
IUUC-Tni-120058 Tetraodon nigroviridis 58.90 0.00e+00 1156.00
IUUC-Tbe-127681 Tupaia belangeri 95.87 0.00e+00 1600.00
IUUC-Ttr-128652 Tursiops truncatus 95.53 0.00e+00 1685.00
IUUC-Vpa-130538 Vicugna pacos 95.04 0.00e+00 1979.00
IUUC-Xtr-132895 Xenopus tropicalis 71.75 0.00e+00 1249.00
Created Date 25-Jun-2017

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