iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053553

Ensembl Protein ID

ENSLAFP00000011859.3

UniProt Accession

G3TCQ2; G3TCQ2_LOXAF

Protein Name

Uncharacterized protein

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014161.3	ENSLAFT00000014163.3	ENSLAFP00000011859.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	5.10e-14	53.0	149	206

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 4    eyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL 62
            +rl+++t ++r+r+lLd+++v+ ++l++fll++++el+++ a + ++++++ + ++ L
   Q: 149  GIRLPIFTSSQRARRLLDLATVKTNGLAAFLLQHVQELPVPSALPFEDAACK-KYMSKL 206
           58*************************************************9.666655 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

LSSSGCEMCT QEGFQAKRSQ LVGLLVSGSL EGFEGVLDWL LSWEVLSWED YESLSVLGQP 60
LSHLARRLLD TVWNKGAWGC EQLMAAVQEA QADSRPLELR GLWDPHSRCP ARDLQSHRPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCCTCCT CAGGTTGTGA AATGTGCACG CAGGAGGGTT TCCAGGCCAA GAGGAGCCAG 60
CTGGTGGGGC TGCTGGTCTC GGGGTCCCTG GAGGGCTTTG AGGGTGTCCT GGACTGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	81.27	0.00e+00	1467.00
IUUC-Ame-011021	Astyanax mexicanus	46.55	0.00e+00	872.00
IUUC-Bta-013241	Bos taurus	80.95	0.00e+00	1604.00
IUUC-Cja-019633	Callithrix jacchus	80.25	0.00e+00	1204.00
IUUC-Cfa-020039	Canis familiaris	81.93	0.00e+00	1578.00
IUUC-Cpo-022337	Cavia porcellus	78.34	0.00e+00	1492.00
IUUC-Csa-023906	Chlorocebus sabaeus	83.17	0.00e+00	1624.00
IUUC-Dre-027568	Danio rerio	47.30	0.00e+00	821.00
IUUC-Dno-029098	Dasypus novemcinctus	82.89	0.00e+00	1504.00
IUUC-Dor-031102	Dipodomys ordii	73.36	0.00e+00	688.00
IUUC-Ete-032943	Echinops telfairi	81.55	0.00e+00	1161.00
IUUC-Eca-034310	Equus caballus	85.20	0.00e+00	1622.00
IUUC-Eeu-034589	Erinaceus europaeus	75.65	1.00e-161	563.00
IUUC-Fca-036252	Felis catus	80.70	0.00e+00	809.00
IUUC-Gac-041442	Gasterosteus aculeatus	44.93	0.00e+00	794.00
IUUC-Ggo-044861	Gorilla gorilla	83.99	0.00e+00	1585.00
IUUC-Hsa-046093	Homo sapiens	83.50	0.00e+00	1579.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	80.36	0.00e+00	1450.00
IUUC-Lch-049454	Latimeria chalumnae	54.92	0.00e+00	944.00
IUUC-Mcc-055772	Macaca mulatta	83.30	0.00e+00	1600.00
IUUC-Meu-056785	Macropus eugenii	71.63	7.00e-120	424.00
IUUC-Mmr-060596	Microcebus murinus	82.53	0.00e+00	1542.00
IUUC-Mdo-062983	Monodelphis domestica	69.53	0.00e+00	1140.00
IUUC-Mmu-063951	Mus musculus	75.94	0.00e+00	1480.00
IUUC-Mpu-066412	Mustela putorius furo	81.64	0.00e+00	1588.00
IUUC-Mlu-067601	Myotis lucifugus	80.83	0.00e+00	1432.00
IUUC-Nle-069913	Nomascus leucogenys	83.78	0.00e+00	1329.00
IUUC-Opr-070999	Ochotona princeps	81.15	0.00e+00	951.00
IUUC-Ont-072512	Oreochromis niloticus	45.68	0.00e+00	857.00
IUUC-Oan-073564	Ornithorhynchus anatinus	62.95	0.00e+00	1108.00
IUUC-Ocu-074837	Oryctolagus cuniculus	83.89	0.00e+00	1583.00
IUUC-Ola-086555	Oryzias latipes	45.14	0.00e+00	796.00
IUUC-Oga-088909	Otolemur garnettii	82.35	0.00e+00	1562.00
IUUC-Oar-089315	Ovis aries	80.28	0.00e+00	1541.00
IUUC-Ptr-090542	Pan troglodytes	83.89	0.00e+00	1583.00
IUUC-Pan-092545	Papio anubis	83.37	0.00e+00	1593.00
IUUC-Pma-094167	Petromyzon marinus	32.81	8.00e-63	234.00
IUUC-Ppa-095344	Physcomitrella patens	25.46	4.00e-05	43.90
IUUC-Pfo-096976	Poecilia formosa	45.29	0.00e+00	842.00
IUUC-Pab-098481	Pongo abelii	83.50	0.00e+00	1570.00
IUUC-Pca-100135	Procavia capensis	83.55	0.00e+00	1439.00
IUUC-Pva-102127	Pteropus vampyrus	80.49	0.00e+00	1425.00
IUUC-Rno-105783	Rattus norvegicus	77.37	0.00e+00	1466.00
IUUC-Sar-113448	Sorex araneus	75.61	0.00e+00	937.00
IUUC-Tru-118708	Takifugu rubripes	44.56	0.00e+00	788.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.75	5.00e-33	134.00
IUUC-Tbe-127661	Tupaia belangeri	82.23	0.00e+00	804.00
IUUC-Ttr-128318	Tursiops truncatus	76.57	0.00e+00	1394.00
IUUC-Vpa-130502	Vicugna pacos	75.26	2.00e-160	560.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence