iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003226

Ensembl Protein ID

ENSAPLP00000001332.1

UniProt Accession

U3I262; U3I262_ANAPL

Genbank Protein ID

ENSAPLP00000001332

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01120600

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000001449.1	ENSAPLT00000001904.1	ENSAPLP00000001332.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.00e-110	366.7	734	1064

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l+e++++  ++ ++n++n  ++kge+++++  ++++lw+++ k++sp++++ +++k++ +f g
   Q: 734  TGLRNLGNTCYMNSILQCLCNAPHLAEYFNRnLYQDDINRSNFLGHKGEVAEEFGVIMKALWTGQYKYISPKDFKITIGKINDQFAG 820
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+qqD+qE+l fl+d+l+e+l+k +n ++ +ee++d  +l+d      a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e 
   Q: 821  YSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENND--HLDDLraaelAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEA 905
           *********************885555544444444..5555556677*************************************** PP
   S: 169  fldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
           f++lslp+ + +++   +lq+cL+ f+kee+l+++n++yc++ck ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+f
   Q: 906  FMYLSLPLASTSKC---TLQECLRLFSKEEKLTDNNRFYCSHCKTRRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDF 987
           *************9...******************************************************996.55.6******** PP
   S: 256  ple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           ple Ldls++++ p+++    k+Y+L++v +H+G+l++GHY+ay+kn +++ W++fdD++V+e++ ++v++   s aY+lfY 
   Q: 988  PLEtLDLSQYVIGPKNN---LKRYNLFSVSNHYGGLDGGHYTAYCKNASKQrWFKFDDHEVSEISSSSVKS---SAAYILFYS 1064
           *************9988...69*************************88778*******************...********7 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MPAVASVPKE LYLCTSLKDL NKKTEIKPEK TSTKSYVQSA LKIFKAAEES RLDRDEEKAY 60
ILYMKYVTVY NFIKKRPDFK QQQDYFHSIL GPTNLKKAVE EAERLSDSLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTGCTG TAGCGTCTGT ACCTAAGGAG CTCTATCTCT GTACTTCACT GAAAGATCTC 60
AACAAGAAGA CAGAAATAAA ACCTGAAAAG ACCAGTACAA AGAGGTGTAT ATTTTCATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	77.27	0.00e+00	910.00
IUUC-Aca-004936	Anolis carolinensis	67.09	0.00e+00	1285.00
IUUC-Ago-007959	Ashbya gossypii	35.81	1.00e-55	211.00
IUUC-Acl-008102	Aspergillus clavatus	32.05	9.00e-52	198.00
IUUC-Afl-008604	Aspergillus flavus	31.16	2.00e-50	194.00
IUUC-Afu-009001	Aspergillus fumigatus	32.05	7.00e-51	196.00
IUUC-Ani-009291	Aspergillus nidulans	31.16	6.00e-51	196.00
IUUC-Ang-009844	Aspergillus niger	32.13	2.00e-50	193.00
IUUC-Aor-010098	Aspergillus oryzae	31.16	6.00e-50	192.00
IUUC-Ate-010585	Aspergillus terreus	31.34	3.00e-50	193.00
IUUC-Ame-010960	Astyanax mexicanus	78.33	2.00e-86	310.00
IUUC-Bta-013008	Bos taurus	90.06	0.00e+00	889.00
IUUC-Bol-015281	Brassica oleracea	38.81	2.00e-48	186.00
IUUC-Bra-017228	Brassica rapa	39.70	3.00e-50	192.00
IUUC-Cel-018482	Caenorhabditis elegans	34.40	5.00e-53	202.00
IUUC-Cja-019173	Callithrix jacchus	77.60	0.00e+00	907.00
IUUC-Cfa-021243	Canis familiaris	77.67	0.00e+00	905.00
IUUC-Cpo-021522	Cavia porcellus	66.29	0.00e+00	1382.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	6.00e-82	296.00
IUUC-Csa-023616	Chlorocebus sabaeus	77.24	0.00e+00	904.00
IUUC-Cho-024381	Choloepus hoffmanni	80.41	0.00e+00	745.00
IUUC-Cin-025287	Ciona intestinalis	49.62	5.00e-97	348.00
IUUC-Csv-026253	Ciona savignyi	49.12	4.00e-87	316.00
IUUC-Cne-026821	Cryptococcus neoformans	40.72	5.00e-75	276.00
IUUC-Dre-028440	Danio rerio	71.34	0.00e+00	726.00
IUUC-Dno-029039	Dasypus novemcinctus	77.60	0.00e+00	924.00
IUUC-Dor-031043	Dipodomys ordii	90.52	4.00e-125	442.00
IUUC-Dse-031463	Dothistroma septosporum	27.78	3.00e-41	164.00
IUUC-Dme-032089	Drosophila melanogaster	46.52	4.00e-84	305.00
IUUC-Ete-033040	Echinops telfairi	73.36	0.00e+00	724.00
IUUC-Eca-033449	Equus caballus	76.79	0.00e+00	909.00
IUUC-Eeu-034693	Erinaceus europaeus	90.52	4.00e-123	435.00
IUUC-Fca-035794	Felis catus	91.16	0.00e+00	856.00
IUUC-Fal-037322	Ficedula albicollis	83.58	0.00e+00	987.00
IUUC-Gmo-038584	Gadus morhua	67.88	0.00e+00	657.00
IUUC-Gga-041188	Gallus gallus	85.83	0.00e+00	985.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.45	0.00e+00	735.00
IUUC-Ggo-045565	Gorilla gorilla	77.56	0.00e+00	912.00
IUUC-Hsa-046438	Homo sapiens	77.56	0.00e+00	911.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	90.26	0.00e+00	899.00
IUUC-Kpa-049321	Komagataella pastoris	33.42	5.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	85.69	0.00e+00	856.00
IUUC-Loc-052769	Lepisosteus oculatus	75.34	0.00e+00	772.00
IUUC-Lma-053021	Leptosphaeria maculans	32.75	9.00e-54	205.00
IUUC-Laf-053432	Loxodonta africana	71.47	0.00e+00	1453.00
IUUC-Mcc-055823	Macaca mulatta	77.40	0.00e+00	909.00
IUUC-Meu-056099	Macropus eugenii	94.80	3.00e-160	558.00
IUUC-Mla-059089	Melampsora laricipopulina	41.10	3.00e-72	266.00
IUUC-Mga-059739	Meleagris gallopavo	86.33	0.00e+00	985.00
IUUC-Mvi-060559	Microbotryum violaceum	42.04	8.00e-78	285.00
IUUC-Mmr-061158	Microcebus murinus	76.46	0.00e+00	905.00
IUUC-Mdo-061801	Monodelphis domestica	80.07	0.00e+00	912.00
IUUC-Mmu-063665	Mus musculus	68.77	0.00e+00	1387.00
IUUC-Mpu-066738	Mustela putorius furo	77.27	0.00e+00	909.00
IUUC-Mlu-067307	Myotis lucifugus	76.14	0.00e+00	921.00
IUUC-Nfi-068410	Neosartorya fischeri	32.13	3.00e-51	196.00
IUUC-Nle-069314	Nomascus leucogenys	77.24	0.00e+00	908.00
IUUC-Opr-070378	Ochotona princeps	66.40	2.00e-132	466.00
IUUC-Ont-071545	Oreochromis niloticus	76.63	0.00e+00	758.00
IUUC-Oan-073537	Ornithorhynchus anatinus	76.73	0.00e+00	895.00
IUUC-Ocu-074193	Oryctolagus cuniculus	90.26	0.00e+00	897.00
IUUC-Ola-086622	Oryzias latipes	58.31	0.00e+00	1088.00
IUUC-Oga-088271	Otolemur garnettii	77.72	0.00e+00	923.00
IUUC-Oar-090431	Ovis aries	75.81	0.00e+00	890.00
IUUC-Ptr-091339	Pan troglodytes	68.55	0.00e+00	1471.00
IUUC-Pan-092266	Papio anubis	88.55	5.00e-171	592.00
IUUC-Psi-093187	Pelodiscus sinensis	69.39	4.00e-164	571.00
IUUC-Pma-094626	Petromyzon marinus	57.48	2.00e-141	495.00
IUUC-Pno-094986	Phaeosphaeria nodorum	30.92	1.00e-38	154.00
IUUC-Pfo-096463	Poecilia formosa	76.22	0.00e+00	752.00
IUUC-Pab-097645	Pongo abelii	77.87	0.00e+00	908.00
IUUC-Pca-100205	Procavia capensis	40.74	3.00e-58	219.00
IUUC-Pva-103222	Pteropus vampyrus	87.94	0.00e+00	700.00
IUUC-Pgr-103408	Puccinia graminis	36.59	3.00e-54	207.00
IUUC-Ptt-103699	Puccinia triticina	46.50	3.00e-67	250.00
IUUC-Pte-104348	Pyrenophora teres	30.07	2.00e-41	164.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.39	2.00e-52	201.00
IUUC-Rno-105510	Rattus norvegicus	89.57	0.00e+00	895.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.26	1.00e-51	197.00
IUUC-Sha-106879	Sarcophilus harrisii	79.62	0.00e+00	904.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	1.00e-49	190.00
IUUC-Sar-113019	Sorex araneus	71.92	0.00e+00	833.00
IUUC-Sre-115031	Sporisorium reilianum	37.33	1.00e-68	254.00
IUUC-Ssc-116334	Sus scrofa	76.05	0.00e+00	893.00
IUUC-Tgu-117062	Taeniopygia guttata	84.24	0.00e+00	997.00
IUUC-Tru-117908	Takifugu rubripes	75.66	0.00e+00	748.00
IUUC-Tsy-118867	Tarsius syrichta	70.57	0.00e+00	796.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.80	0.00e+00	729.00
IUUC-Tme-127144	Tuber melanosporum	40.11	8.00e-79	288.00
IUUC-Tbe-127877	Tupaia belangeri	90.85	1.00e-77	285.00
IUUC-Ttr-128580	Tursiops truncatus	75.77	0.00e+00	893.00
IUUC-Uma-129340	Ustilago maydis	37.85	2.00e-72	267.00
IUUC-Vpa-130541	Vicugna pacos	75.40	0.00e+00	870.00
IUUC-Xtr-132161	Xenopus tropicalis	58.66	0.00e+00	1166.00
IUUC-Xma-134271	Xiphophorus maculatus	75.61	0.00e+00	746.00
IUUC-Yli-134561	Yarrowia lipolytica	36.63	7.00e-61	228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence