iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003368

Ensembl Protein ID

ENSAPLP00000007325.1

UniProt Accession

U3IJA3; U3IJA3_ANAPL

Genbank Protein ID

ENSAPLP00000007325

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01120543

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000007654.1	ENSAPLT00000007985.1	ENSAPLP00000007325.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.00e-116	386.6	626	1361

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ ++++++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 626  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFESEINYNNPLGTGGRLAIGFAMLLRALWKGTHHAFQPSKLKAIVASKASQFTG 712
           7******************************99****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c +vs +++p
   Q: 713  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCSKVSITFDP 797
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 798  FLYLPVPLPQKQKVLTVyyfakephkkpikflvsiskenssamevldsvahsvrvkpenlrlaeviknrfhrmflpshcldtvcptd 884
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 885  lllcfevlspelakervvelqvqqrpqvpsvpvakcaacqkkqlseeeklrrctrcyrvgycnvacqkthwpdhkalcrpenigfpf 971
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 972  lisvpesrltyarlaqllegyarysvsvfqppfqlgrmspeqglqpllpdkpeplakssctaatsapelgdedrasgllqepplspa 1058
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1059 vpelhpelgdsstvrskvlparssllsldsgfsehvesqgdsccekepsyeralkpeaaipgyqhtpdslsaratqfyinkidaank 1145
           *************************************************************************************** PP
   S: 186  ...........................................................slqdcLesftkeeelegenkyycekckk 213
                                                                      +l++cL+ ftk+e l  e+++yc+kck+
   Q: 1146 eykledkgdapleltddcslalvwknnerlkefvlveskelecvedpgsaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQ 1232
           *************************************************************************************** PP
   S: 214  kqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayv 299
           ++ea+k+l+l++lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++ +q +   Y+L+av++H+G++ +GHY+ay+
   Q: 1233 HREASKQLMLWRLPNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRsLDLSKFCIGRKGEQ-QLPMYDLYAVINHYGGMIGGHYTAYA 1317
           *****************************8886.*********************88776.5************************* PP
   S: 300  knekgk........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +  ++k        W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1318 RLPNDKnsqrsdvgWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1361
           *9554455677888*******************...********996 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

PQRVAKIAGP GRKRRTPDPD SITDPGGPFV SSKRLKMSSS TNAPGQRRVS RGLDDATNKK 60
KQKDRANQES KEGESPRRDA FSAPWAWAPQ TGAEPAGGAV ASPSRRMGLS TTKHRALCVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCACAGAGAG TCGCCAAGAT AGCTGGGCCA GGAAGAAAAC GTCGCACCCC TGACCCAGAC 60
TCCATCACCG ACCCCGGCGG GCCGTTTGTG TCCTCCAAAC GGCTGAAGAT GTCCAGTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	66.83	0.00e+00	1746.00
IUUC-Aca-004267	Anolis carolinensis	77.26	0.00e+00	1883.00
IUUC-Ame-010970	Astyanax mexicanus	71.46	0.00e+00	1372.00
IUUC-Bta-012905	Bos taurus	67.84	0.00e+00	1732.00
IUUC-Cel-018257	Caenorhabditis elegans	44.30	1.00e-90	327.00
IUUC-Cja-018789	Callithrix jacchus	67.13	0.00e+00	1709.00
IUUC-Cfa-021004	Canis familiaris	66.97	0.00e+00	1725.00
IUUC-Cpo-021529	Cavia porcellus	65.90	0.00e+00	1660.00
IUUC-Csa-024035	Chlorocebus sabaeus	68.93	0.00e+00	1677.00
IUUC-Cho-025036	Choloepus hoffmanni	59.48	0.00e+00	875.00
IUUC-Cin-025451	Ciona intestinalis	42.22	2.00e-83	303.00
IUUC-Dre-028556	Danio rerio	70.69	0.00e+00	1360.00
IUUC-Dno-029240	Dasypus novemcinctus	67.86	0.00e+00	1502.00
IUUC-Dor-030495	Dipodomys ordii	75.20	0.00e+00	947.00
IUUC-Ete-032741	Echinops telfairi	75.15	0.00e+00	1474.00
IUUC-Eca-033661	Equus caballus	67.18	0.00e+00	1690.00
IUUC-Eeu-034648	Erinaceus europaeus	75.16	0.00e+00	651.00
IUUC-Fca-035646	Felis catus	66.93	0.00e+00	1714.00
IUUC-Fal-037094	Ficedula albicollis	89.44	0.00e+00	2234.00
IUUC-Gmo-038869	Gadus morhua	71.61	0.00e+00	864.00
IUUC-Gga-041170	Gallus gallus	89.89	0.00e+00	2218.00
IUUC-Gac-041901	Gasterosteus aculeatus	66.92	0.00e+00	1342.00
IUUC-Ggo-044708	Gorilla gorilla	66.67	0.00e+00	1708.00
IUUC-Hsa-046791	Homo sapiens	73.01	0.00e+00	1517.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	67.18	0.00e+00	1626.00
IUUC-Lch-050456	Latimeria chalumnae	54.03	0.00e+00	1233.00
IUUC-Loc-052861	Lepisosteus oculatus	64.75	0.00e+00	1211.00
IUUC-Laf-053788	Loxodonta africana	66.40	0.00e+00	1640.00
IUUC-Mcc-055693	Macaca mulatta	66.31	0.00e+00	1721.00
IUUC-Meu-055921	Macropus eugenii	79.79	0.00e+00	1346.00
IUUC-Mga-059879	Meleagris gallopavo	87.92	0.00e+00	2303.00
IUUC-Mmr-060802	Microcebus murinus	66.62	0.00e+00	1686.00
IUUC-Mdo-061856	Monodelphis domestica	78.93	0.00e+00	1502.00
IUUC-Mmu-063874	Mus musculus	70.43	0.00e+00	1673.00
IUUC-Mpu-066166	Mustela putorius furo	67.02	0.00e+00	1724.00
IUUC-Nle-070161	Nomascus leucogenys	67.27	0.00e+00	1737.00
IUUC-Opr-071015	Ochotona princeps	76.08	0.00e+00	1496.00
IUUC-Ont-072308	Oreochromis niloticus	70.88	0.00e+00	1408.00
IUUC-Oan-072723	Ornithorhynchus anatinus	68.90	0.00e+00	1584.00
IUUC-Ocu-073938	Oryctolagus cuniculus	67.09	0.00e+00	1736.00
IUUC-Ola-086375	Oryzias latipes	70.75	0.00e+00	1362.00
IUUC-Oga-088297	Otolemur garnettii	65.81	0.00e+00	1658.00
IUUC-Oar-089675	Ovis aries	63.61	0.00e+00	1563.00
IUUC-Ptr-091621	Pan troglodytes	73.30	0.00e+00	1512.00
IUUC-Pan-092118	Papio anubis	66.36	0.00e+00	1776.00
IUUC-Pma-094154	Petromyzon marinus	51.20	2.00e-112	399.00
IUUC-Pfo-097246	Poecilia formosa	61.22	0.00e+00	1469.00
IUUC-Pab-098551	Pongo abelii	72.62	0.00e+00	1498.00
IUUC-Pca-100158	Procavia capensis	63.94	0.00e+00	1590.00
IUUC-Pva-103160	Pteropus vampyrus	70.12	0.00e+00	1603.00
IUUC-Rno-105355	Rattus norvegicus	70.14	0.00e+00	1640.00
IUUC-Sha-107057	Sarcophilus harrisii	69.63	0.00e+00	1812.00
IUUC-Sar-113011	Sorex araneus	72.86	0.00e+00	1129.00
IUUC-Ssc-115761	Sus scrofa	67.42	0.00e+00	1750.00
IUUC-Tgu-116956	Taeniopygia guttata	76.12	0.00e+00	972.00
IUUC-Tru-118739	Takifugu rubripes	68.48	0.00e+00	1395.00
IUUC-Tsy-118827	Tarsius syrichta	61.69	0.00e+00	896.00
IUUC-Tni-119921	Tetraodon nigroviridis	67.25	0.00e+00	1329.00
IUUC-Tbe-128017	Tupaia belangeri	71.11	0.00e+00	1461.00
IUUC-Ttr-128869	Tursiops truncatus	70.38	0.00e+00	1615.00
IUUC-Uma-129498	Ustilago maydis	31.74	5.00e-95	342.00
IUUC-Vpa-130427	Vicugna pacos	72.13	0.00e+00	703.00
IUUC-Xtr-132734	Xenopus tropicalis	64.31	0.00e+00	1689.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence