iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000049531.2	ENSRNOT00000085038.1	ENSRNOP00000069554.1
ENSRNOG00000049531.2	ENSRNOT00000074772.2	ENSRNOP00000067744.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-115	384.7	536	1253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 536  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTG 622
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 623  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 707
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 708  FLYLPVPLPQKQKVLPIyyfarephskpikflvsvskenssasevleslsqsvhvkpeslrlaeviknrfhrvflpshsldavsptd 794
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 795  vllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqsedeklkrctrcyrvgycnqfcqkthwpdhkglcrpenigypf 881
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 882  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstssleagdserepiqpselqlvtpvaegdtgahrm 968
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 969  wppadrgpvpstsgissemlasgpmegcsllagervsrpeaavpgyqhsresvsahtpqffiykidassreqrledkgdtplelgdd 1055
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1056 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1142
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.....ekgk.....W 306
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++      +  +     W
   Q: 1143 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLpsdrsS--QrsdvgW 1224
           ************8886.**********9**********99888..9**************************665541..155677* PP
   S: 307  llfdDskVtevkeeevleetgstaYvlfYkrr 338
            lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1225 RLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1253
           ******************...********996 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSAGTSATGP RRGPPGLEEA TSKKKQKDRA NQESKDGDPR RVSMPRKEPT KDELLLDWRQ 60
SSDEVVVKLR VGTGPICLEE VDAAFTDTDC VVRLPDGRQW GGVFFAEIQS SCTKVQTRKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGCCGTATC TAGAAGTCGA AACAAAACAA GCGGCTGAAG CGGCGGCGGC GGAGCCGGGA 60
CGGGGGAGGG GCGCGCCGGA ACCGGAACCG ACCCGACGCC GGAACCGGAA TCGAGAGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	88.66	0.00e+00	2228.00
IUUC-Apl-003368	Anas platyrhynchos	70.14	0.00e+00	1660.00
IUUC-Aca-004267	Anolis carolinensis	67.38	0.00e+00	1669.00
IUUC-Ame-010970	Astyanax mexicanus	69.55	0.00e+00	1320.00
IUUC-Bta-012905	Bos taurus	87.69	0.00e+00	2225.00
IUUC-Cja-018789	Callithrix jacchus	86.81	0.00e+00	2344.00
IUUC-Cfa-021004	Canis familiaris	91.44	0.00e+00	2172.00
IUUC-Cpo-021529	Cavia porcellus	88.57	0.00e+00	2325.00
IUUC-Csa-024035	Chlorocebus sabaeus	90.13	0.00e+00	2266.00
IUUC-Cho-025036	Choloepus hoffmanni	84.41	0.00e+00	1226.00
IUUC-Cin-025451	Ciona intestinalis	43.41	3.00e-86	313.00
IUUC-Csv-025931	Ciona savignyi	36.73	1.00e-111	397.00
IUUC-Dre-028556	Danio rerio	68.83	0.00e+00	1305.00
IUUC-Dno-029240	Dasypus novemcinctus	86.09	0.00e+00	2135.00
IUUC-Dor-030495	Dipodomys ordii	93.25	0.00e+00	1245.00
IUUC-Ete-032741	Echinops telfairi	90.83	0.00e+00	1816.00
IUUC-Eca-033661	Equus caballus	92.26	0.00e+00	2387.00
IUUC-Eeu-034648	Erinaceus europaeus	90.61	0.00e+00	803.00
IUUC-Fca-035646	Felis catus	87.12	0.00e+00	2184.00
IUUC-Fal-037094	Ficedula albicollis	68.05	0.00e+00	1776.00
IUUC-Gmo-038869	Gadus morhua	70.80	0.00e+00	826.00
IUUC-Gga-041170	Gallus gallus	65.70	0.00e+00	1719.00
IUUC-Gac-041901	Gasterosteus aculeatus	65.76	0.00e+00	1294.00
IUUC-Ggo-044708	Gorilla gorilla	86.96	0.00e+00	2347.00
IUUC-Hsa-046791	Homo sapiens	92.74	0.00e+00	2018.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	86.91	0.00e+00	2303.00
IUUC-Lch-050456	Latimeria chalumnae	52.17	0.00e+00	1195.00
IUUC-Loc-052861	Lepisosteus oculatus	61.58	0.00e+00	1120.00
IUUC-Laf-053788	Loxodonta africana	89.50	0.00e+00	2278.00
IUUC-Mcc-055693	Macaca mulatta	85.70	0.00e+00	2239.00
IUUC-Meu-055921	Macropus eugenii	78.72	0.00e+00	1508.00
IUUC-Mga-059879	Meleagris gallopavo	68.45	0.00e+00	1707.00
IUUC-Mmr-060802	Microcebus murinus	89.19	0.00e+00	2382.00
IUUC-Mdo-061856	Monodelphis domestica	82.52	0.00e+00	1617.00
IUUC-Mmu-063874	Mus musculus	95.37	0.00e+00	2494.00
IUUC-Mpu-066166	Mustela putorius furo	89.66	0.00e+00	2144.00
IUUC-Nle-070161	Nomascus leucogenys	87.32	0.00e+00	2388.00
IUUC-Opr-071015	Ochotona princeps	92.06	0.00e+00	1899.00
IUUC-Ont-072308	Oreochromis niloticus	68.94	0.00e+00	1349.00
IUUC-Oan-072723	Ornithorhynchus anatinus	65.26	0.00e+00	1635.00
IUUC-Ocu-073938	Oryctolagus cuniculus	87.29	0.00e+00	2198.00
IUUC-Ola-086375	Oryzias latipes	70.26	0.00e+00	1322.00
IUUC-Oga-088297	Otolemur garnettii	87.65	0.00e+00	2304.00
IUUC-Oar-089675	Ovis aries	81.87	0.00e+00	1986.00
IUUC-Ptr-091621	Pan troglodytes	92.65	0.00e+00	2016.00
IUUC-Pan-092118	Papio anubis	86.49	0.00e+00	2257.00
IUUC-Pma-094154	Petromyzon marinus	51.31	2.00e-113	403.00
IUUC-Pfo-097246	Poecilia formosa	59.78	0.00e+00	1383.00
IUUC-Pab-098551	Pongo abelii	91.94	0.00e+00	1999.00
IUUC-Pca-100158	Procavia capensis	86.24	0.00e+00	2242.00
IUUC-Pva-103160	Pteropus vampyrus	91.40	0.00e+00	2322.00
IUUC-Sha-107057	Sarcophilus harrisii	76.05	0.00e+00	1758.00
IUUC-Sar-113011	Sorex araneus	88.17	0.00e+00	1457.00
IUUC-Ssc-115761	Sus scrofa	86.62	0.00e+00	2236.00
IUUC-Tgu-116956	Taeniopygia guttata	63.19	0.00e+00	821.00
IUUC-Tru-118739	Takifugu rubripes	68.55	0.00e+00	1330.00
IUUC-Tsy-118827	Tarsius syrichta	84.35	0.00e+00	1246.00
IUUC-Tni-119921	Tetraodon nigroviridis	60.14	0.00e+00	1393.00
IUUC-Tbe-128017	Tupaia belangeri	90.41	0.00e+00	1951.00
IUUC-Ttr-128869	Tursiops truncatus	90.73	0.00e+00	2325.00
IUUC-Vpa-130427	Vicugna pacos	92.31	0.00e+00	892.00
IUUC-Xtr-132734	Xenopus tropicalis	60.56	0.00e+00	1524.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence