iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000021564.3	ENSMMUT00000045460.2	ENSMMUP00000038490.2
ENSMMUG00000021564.3	ENSMMUT00000045458.2	ENSMMUP00000038487.2
ENSMMUG00000021564.3	ENSMMUT00000030348.3	ENSMMUP00000028400.3
ENSMMUG00000021564.3	ENSMMUT00000058692.1	ENSMMUP00000047813.1
ENSMMUG00000021564.3	ENSMMUT00000070818.1	ENSMMUP00000049221.1
ENSMMUG00000021564.3	ENSMMUT00000059345.1	ENSMMUP00000054232.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.40e-14	54.4	660	725

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk++     v++elpn+  w+CpkC+++
   Q: 660  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKIKesegvVNDELPNC--WECPKCNHA 725
           79*********9977765156789*********************************..*******85 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAGPQMGGSA EDHPSRKRHA AEKQKKETII YTKCYEFESA TQRPIDRQRY DENEDLSDVE 60
EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCAGTG TGAGCCCTGG CAGCGGCACA TACACGCTTT GTGATCCTGG GTGAGTGGCT 60
TTGCTTTTCT TAGTCCTAAT TTCCTCCTTT GCAAGATAGG AACGAACAAC ACGATTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	96.01	0.00e+00	2276.00
IUUC-Apl-003787	Anas platyrhynchos	83.92	0.00e+00	1924.00
IUUC-Aca-004247	Anolis carolinensis	78.63	0.00e+00	1812.00
IUUC-Ame-011463	Astyanax mexicanus	75.00	5.00e-168	585.00
IUUC-Bta-013531	Bos taurus	96.46	0.00e+00	2313.00
IUUC-Cel-018303	Caenorhabditis elegans	44.55	4.00e-82	300.00
IUUC-Cja-018876	Callithrix jacchus	93.31	0.00e+00	2248.00
IUUC-Cfa-020857	Canis familiaris	96.61	0.00e+00	2311.00
IUUC-Cpo-021967	Cavia porcellus	93.13	0.00e+00	2120.00
IUUC-Csa-023210	Chlorocebus sabaeus	99.77	0.00e+00	2305.00
IUUC-Dre-028272	Danio rerio	64.26	0.00e+00	1523.00
IUUC-Dno-030034	Dasypus novemcinctus	94.53	0.00e+00	2223.00
IUUC-Dor-030736	Dipodomys ordii	86.15	0.00e+00	993.00
IUUC-Eca-034255	Equus caballus	97.27	0.00e+00	2232.00
IUUC-Eeu-035038	Erinaceus europaeus	97.36	0.00e+00	1182.00
IUUC-Fca-035786	Felis catus	96.25	0.00e+00	2279.00
IUUC-Fal-037589	Ficedula albicollis	83.54	0.00e+00	2033.00
IUUC-Gga-041103	Gallus gallus	86.58	0.00e+00	1145.00
IUUC-Gac-041304	Gasterosteus aculeatus	61.45	0.00e+00	1508.00
IUUC-Ggo-044522	Gorilla gorilla	99.41	0.00e+00	1766.00
IUUC-Hsa-045877	Homo sapiens	99.10	0.00e+00	2400.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	96.71	0.00e+00	1321.00
IUUC-Lch-049950	Latimeria chalumnae	77.73	0.00e+00	1896.00
IUUC-Loc-051972	Lepisosteus oculatus	71.70	0.00e+00	1095.00
IUUC-Laf-053623	Loxodonta africana	96.45	0.00e+00	2195.00
IUUC-Meu-056259	Macropus eugenii	86.17	0.00e+00	2081.00
IUUC-Mga-059671	Meleagris gallopavo	84.39	0.00e+00	1982.00
IUUC-Mmr-061003	Microcebus murinus	96.30	0.00e+00	2291.00
IUUC-Mmu-063584	Mus musculus	93.61	0.00e+00	2228.00
IUUC-Mpu-066056	Mustela putorius furo	96.46	0.00e+00	2280.00
IUUC-Mlu-067850	Myotis lucifugus	95.76	0.00e+00	2273.00
IUUC-Nle-069837	Nomascus leucogenys	96.29	0.00e+00	2075.00
IUUC-Opr-070943	Ochotona princeps	91.47	0.00e+00	2159.00
IUUC-Ont-071663	Oreochromis niloticus	65.53	0.00e+00	1587.00
IUUC-Oan-072934	Ornithorhynchus anatinus	75.47	0.00e+00	1252.00
IUUC-Ocu-074706	Oryctolagus cuniculus	96.38	0.00e+00	2306.00
IUUC-Ola-086543	Oryzias latipes	63.83	0.00e+00	1556.00
IUUC-Oga-088671	Otolemur garnettii	83.92	0.00e+00	1003.00
IUUC-Oar-089560	Ovis aries	91.66	0.00e+00	2211.00
IUUC-Ptr-090875	Pan troglodytes	99.10	0.00e+00	2429.00
IUUC-Pan-091788	Papio anubis	96.34	0.00e+00	2336.00
IUUC-Psi-093382	Pelodiscus sinensis	83.85	0.00e+00	2026.00
IUUC-Pfo-096272	Poecilia formosa	63.51	0.00e+00	1493.00
IUUC-Pab-097907	Pongo abelii	94.54	0.00e+00	2245.00
IUUC-Pca-100628	Procavia capensis	85.62	0.00e+00	1870.00
IUUC-Pva-102956	Pteropus vampyrus	94.94	0.00e+00	1184.00
IUUC-Rno-105722	Rattus norvegicus	94.99	0.00e+00	1816.00
IUUC-Sha-106626	Sarcophilus harrisii	80.91	0.00e+00	1841.00
IUUC-Ssc-115918	Sus scrofa	95.63	0.00e+00	1762.00
IUUC-Tru-118638	Takifugu rubripes	69.38	0.00e+00	989.00
IUUC-Tbe-127654	Tupaia belangeri	80.00	0.00e+00	1682.00
IUUC-Ttr-128821	Tursiops truncatus	88.27	0.00e+00	2096.00
IUUC-Xtr-131823	Xenopus tropicalis	74.77	0.00e+00	1758.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence