iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ata-000686

Ensembl Protein ID

EMT19309

UniProt Accession

R7WFS4; R7WFS4_AEGTA

Genbank Protein ID

EMT19309.1

Protein Name

Presenilin

Genbank Nucleotide ID

KD529733

Gene Name

F775_12510

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
F775_12510	EMT19309	EMT19309

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	29.89	1.00e-29	129.00	IUUC-Cel-018553
UBD/Alpha-Helix/CUE	33.55	3.00e-21	102.00	IUUC-Dre-028689
UBD/Alpha-Helix/CUE	33.66	3.00e-21	102.00	IUUC-Hsa-046822

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aegilops tauschii

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MDPVADAPDP PGSAATVLDT LGEEVLAVMS PVSICMALVV LLITLLAPPS SSPSAPPPVT 60
AATLVYLESP SDSPAQKLVG ALLDAAVFVA LVAVVTFILV ALYYYRCTGF LKNYMRFSAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCCCG TCGCCGACGC GCCGGACCCG CCCGGCTCCG CCGCCACCGT CCTCGACACC 60
CTGGGCGAGG AGGTGCTCGC GGTCATGTCC CCGGTCTCCA TCTGCATGGC CCTCGTCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR005174--DUF295
IPR001810--F-box_dom
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF03478--DUF295
PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

KEGG

ats:F775_12510

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	34.18	7.00e-31	127.00
IUUC-Atr-003039	Amborella trichopoda	53.64	6.00e-104	370.00
IUUC-Apl-003727	Anas platyrhynchos	31.14	3.00e-31	128.00
IUUC-Aca-004582	Anolis carolinensis	31.49	5.00e-32	131.00
IUUC-Aly-005455	Arabidopsis lyrata	58.33	9.00e-57	213.00
IUUC-Ath-006730	Arabidopsis thaliana	57.89	2.00e-57	215.00
IUUC-Ame-010686	Astyanax mexicanus	31.06	1.00e-28	120.00
IUUC-Bta-013026	Bos taurus	31.28	8.00e-32	130.00
IUUC-Bdi-014196	Brachypodium distachyon	83.18	1.00e-152	532.00
IUUC-Bol-015841	Brassica oleracea	49.57	2.00e-88	318.00
IUUC-Bra-017580	Brassica rapa	58.22	2.00e-43	169.00
IUUC-Cel-018553	Caenorhabditis elegans	30.86	1.00e-41	162.00
IUUC-Cja-019994	Callithrix jacchus	30.18	4.00e-29	121.00
IUUC-Cfa-020074	Canis familiaris	32.42	4.00e-32	131.00
IUUC-Cpo-022237	Cavia porcellus	32.04	2.00e-32	132.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	45.18	2.00e-44	172.00
IUUC-Csa-023537	Chlorocebus sabaeus	30.34	4.00e-30	125.00
IUUC-Cho-024735	Choloepus hoffmanni	32.40	2.00e-26	112.00
IUUC-Cin-025780	Ciona intestinalis	31.65	5.00e-39	154.00
IUUC-Csv-025967	Ciona savignyi	32.05	1.00e-24	106.00
IUUC-Dre-028689	Danio rerio	28.37	3.00e-20	92.40
IUUC-Dno-029758	Dasypus novemcinctus	31.14	4.00e-31	128.00
IUUC-Dor-030609	Dipodomys ordii	53.09	3.00e-18	85.90
IUUC-Dme-031929	Drosophila melanogaster	36.65	1.00e-28	120.00
IUUC-Ete-032487	Echinops telfairi	59.26	5.00e-12	65.10
IUUC-Eca-034387	Equus caballus	32.66	3.00e-27	115.00
IUUC-Eeu-035134	Erinaceus europaeus	33.95	9.00e-30	123.00
IUUC-Fca-036243	Felis catus	31.95	2.00e-32	132.00
IUUC-Fal-036600	Ficedula albicollis	30.21	4.00e-33	135.00
IUUC-Gmo-039665	Gadus morhua	32.94	1.00e-19	90.50
IUUC-Ggr-039835	Gaeumannomyces graminis	37.78	6.40e-01	28.50
IUUC-Gga-040993	Gallus gallus	31.12	2.00e-33	135.00
IUUC-Gac-042511	Gasterosteus aculeatus	30.43	5.00e-25	108.00
IUUC-Gma-043822	Glycine max	63.76	1.00e-43	169.00
IUUC-Ggo-045338	Gorilla gorilla	32.14	3.00e-28	119.00
IUUC-Hsa-046822	Homo sapiens	30.34	4.00e-30	125.00
IUUC-Hvu-047141	Hordeum vulgare	97.34	0.00e+00	639.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	33.52	7.00e-33	133.00
IUUC-Lch-049638	Latimeria chalumnae	31.67	3.00e-25	108.00
IUUC-Lpe-051132	Leersia perrieri	74.89	2.00e-123	434.00
IUUC-Loc-052427	Lepisosteus oculatus	30.34	2.00e-35	142.00
IUUC-Laf-053979	Loxodonta africana	32.35	6.00e-30	124.00
IUUC-Mcc-055682	Macaca mulatta	30.34	4.00e-30	125.00
IUUC-Meu-056004	Macropus eugenii	29.41	3.00e-20	92.40
IUUC-Mtr-058392	Medicago truncatula	52.82	7.00e-95	340.00
IUUC-Mga-059466	Meleagris gallopavo	31.58	1.00e-33	136.00
IUUC-Mmr-060890	Microcebus murinus	32.14	2.00e-28	119.00
IUUC-Mdo-062122	Monodelphis domestica	30.41	6.00e-29	121.00
IUUC-Mmu-063176	Mus musculus	31.22	3.00e-21	95.90
IUUC-Mac-064858	Musa acuminata	92.41	3.00e-38	151.00
IUUC-Mpu-065927	Mustela putorius furo	30.41	8.00e-30	124.00
IUUC-Mlu-067079	Myotis lucifugus	31.49	9.00e-35	140.00
IUUC-Nle-070180	Nomascus leucogenys	30.34	4.00e-30	125.00
IUUC-Opr-070344	Ochotona princeps	32.03	6.00e-27	114.00
IUUC-Ont-071846	Oreochromis niloticus	29.72	7.00e-28	117.00
IUUC-Oan-072783	Ornithorhynchus anatinus	35.29	5.00e-30	124.00
IUUC-Ocu-074527	Oryctolagus cuniculus	31.58	3.00e-33	135.00
IUUC-Oba-075256	Oryza barthii	74.20	2.00e-109	388.00
IUUC-Obr-076302	Oryza brachyantha	77.83	3.00e-129	454.00
IUUC-Ogl-077097	Oryza glaberrima	74.50	8.00e-125	439.00
IUUC-Ogu-078570	Oryza glumaepatula	76.02	1.00e-119	422.00
IUUC-Oin-079244	Oryza indica	74.27	2.00e-124	438.00
IUUC-Olo-080484	Oryza longistaminata	75.97	9.00e-79	285.00
IUUC-Ome-081814	Oryza meridionalis	78.40	1.00e-130	459.00
IUUC-Oni-082057	Oryza nivara	76.02	9.00e-120	422.00
IUUC-Opu-084176	Oryza punctata	78.63	3.00e-123	434.00
IUUC-Oru-084618	Oryza rufipogon	76.02	5.00e-120	423.00
IUUC-Osa-085602	Oryza sativa	75.95	2.00e-121	428.00
IUUC-Ola-086707	Oryzias latipes	31.51	4.00e-26	110.00
IUUC-Olu-087811	Ostreococcus lucimarinus	42.72	7.00e-41	160.00
IUUC-Oga-088560	Otolemur garnettii	31.79	9.00e-29	120.00
IUUC-Oar-090348	Ovis aries	30.18	3.00e-31	129.00
IUUC-Ptr-091060	Pan troglodytes	30.34	4.00e-30	125.00
IUUC-Pan-091742	Papio anubis	32.14	2.00e-28	119.00
IUUC-Psi-093505	Pelodiscus sinensis	30.11	3.00e-32	132.00
IUUC-Pma-094612	Petromyzon marinus	29.21	9.00e-24	103.00
IUUC-Ppa-095431	Physcomitrella patens	44.40	6.00e-85	307.00
IUUC-Pfo-097396	Poecilia formosa	30.02	3.00e-36	145.00
IUUC-Pab-098591	Pongo abelii	30.34	3.00e-30	125.00
IUUC-Pop-099661	Populus trichocarpa	53.54	4.00e-49	187.00
IUUC-Pca-101029	Procavia capensis	33.12	2.00e-25	109.00
IUUC-Ppe-101495	Prunus persica	51.36	5.00e-103	367.00
IUUC-Pva-102934	Pteropus vampyrus	30.83	7.00e-26	110.00
IUUC-Rno-105861	Rattus norvegicus	31.67	3.00e-21	95.50
IUUC-Sha-107045	Sarcophilus harrisii	29.72	6.00e-29	121.00
IUUC-Smo-109325	Selaginella moellendorffii	48.90	8.00e-37	147.00
IUUC-Sit-110624	Setaria italica	75.06	4.00e-122	430.00
IUUC-Sly-110865	Solanum lycopersicum	88.52	2.00e-28	116.00
IUUC-Stu-112433	Solanum tuberosum	55.63	1.00e-97	348.00
IUUC-Sar-113169	Sorex araneus	42.06	1.00e-19	90.10
IUUC-Sbi-114305	Sorghum bicolor	74.23	9.00e-126	442.00
IUUC-Ssc-115766	Sus scrofa	29.95	8.00e-29	120.00
IUUC-Tgu-116469	Taeniopygia guttata	32.29	3.00e-30	124.00
IUUC-Tru-117732	Takifugu rubripes	30.34	4.00e-32	131.00
IUUC-Tsy-119303	Tarsius syrichta	43.04	2.00e-05	43.50
IUUC-Tni-119852	Tetraodon nigroviridis	29.69	2.00e-30	125.00
IUUC-Tca-121865	Theobroma cacao	66.84	6.00e-58	217.00
IUUC-Tae-123984	Triticum aestivum	98.00	0.00e+00	635.00
IUUC-Tur-126237	Triticum urartu	97.70	3.00e-158	550.00
IUUC-Tbe-127632	Tupaia belangeri	32.14	4.00e-28	118.00
IUUC-Ttr-128793	Tursiops truncatus	34.37	4.00e-28	118.00
IUUC-Vpa-130625	Vicugna pacos	40.95	1.00e-18	87.00
IUUC-Vvi-131312	Vitis vinifera	51.66	8.00e-94	336.00
IUUC-Xtr-131790	Xenopus tropicalis	32.13	3.00e-23	102.00
IUUC-Xma-133377	Xiphophorus maculatus	30.77	7.00e-21	94.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence