iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pma-094612

Ensembl Protein ID

ENSPMAP00000007887.1

UniProt Accession

S4RRQ1; S4RRQ1_PETMA

Protein Name

Presenilin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000007147.1	ENSPMAT00000007922.1	ENSPMAP00000007887.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	2.00e-07	30.2	261	289

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++v+++ +++
   Q: 261  VETAQERNEPIFPALIYSSTMVWMVGMAD 289
           89**********************99987 PP

Organism

Petromyzon marinus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MSEAVGGQEG VGIAAAQDGL PQVTTTTRQR GERREDGDGS GSGRERSHSE PHTDEESEEE 60
ELSLKYGAKH VIMLFVPVTL CMLVVVATIK SVTFYTEKNG QLIYTPFTED TDTVGQRVLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCAGCAGCT GCGGAGCCGG CGAAGTTCGG CAGTGGATGA GCGTTTCTGA GAAGAGAGGA 60
GGAGGCTGCG GTGAAGAGAG CTTTCTCATG GAGGCCGTGG TTTCCAGCGA GCGCCGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0022008--P:neurogenesis
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	58.75	3.00e-14	72.40
IUUC-Aml-002356	Ailuropoda melanoleuca	68.60	4.00e-116	409.00
IUUC-Atr-003039	Amborella trichopoda	28.88	5.00e-22	97.40
IUUC-Apl-003959	Anas platyrhynchos	70.20	3.00e-132	463.00
IUUC-Aca-005160	Anolis carolinensis	68.13	2.00e-140	491.00
IUUC-Aly-005455	Arabidopsis lyrata	29.77	1.00e-18	86.30
IUUC-Ath-006730	Arabidopsis thaliana	31.16	2.00e-19	88.60
IUUC-Ame-010686	Astyanax mexicanus	76.32	2.00e-138	483.00
IUUC-Bta-013097	Bos taurus	74.93	2.00e-137	480.00
IUUC-Bdi-014196	Brachypodium distachyon	29.41	2.00e-19	89.40
IUUC-Bol-015841	Brassica oleracea	61.25	3.00e-16	77.80
IUUC-Bra-017580	Brassica rapa	61.25	4.00e-16	77.80
IUUC-Cel-018553	Caenorhabditis elegans	51.87	7.00e-93	332.00
IUUC-Cja-018824	Callithrix jacchus	65.05	3.00e-134	469.00
IUUC-Cfa-020253	Canis familiaris	66.37	1.00e-138	484.00
IUUC-Cpo-021401	Cavia porcellus	67.25	1.00e-138	484.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.26	6.00e-29	120.00
IUUC-Csa-023369	Chlorocebus sabaeus	66.37	2.00e-138	483.00
IUUC-Cho-024735	Choloepus hoffmanni	63.38	8.00e-117	412.00
IUUC-Cin-025780	Ciona intestinalis	61.85	4.00e-117	412.00
IUUC-Csv-025967	Ciona savignyi	61.99	4.00e-119	419.00
IUUC-Dre-028526	Danio rerio	76.32	7.00e-141	492.00
IUUC-Dno-029758	Dasypus novemcinctus	70.66	1.00e-126	444.00
IUUC-Dor-031127	Dipodomys ordii	67.11	4.00e-135	473.00
IUUC-Dme-031929	Drosophila melanogaster	55.56	2.00e-105	374.00
IUUC-Ete-033081	Echinops telfairi	60.54	3.00e-67	247.00
IUUC-Eca-034387	Equus caballus	75.46	1.00e-138	484.00
IUUC-Eeu-035134	Erinaceus europaeus	67.42	4.00e-93	333.00
IUUC-Fca-035396	Felis catus	76.90	7.00e-144	502.00
IUUC-Fal-037457	Ficedula albicollis	70.59	1.00e-135	474.00
IUUC-Gmo-038550	Gadus morhua	70.68	5.00e-123	432.00
IUUC-Gga-040706	Gallus gallus	69.11	3.00e-135	473.00
IUUC-Gac-042511	Gasterosteus aculeatus	73.25	1.00e-124	438.00
IUUC-Gma-043822	Glycine max	35.26	3.00e-23	101.00
IUUC-Ggo-045338	Gorilla gorilla	65.49	3.00e-138	483.00
IUUC-Hsa-046455	Homo sapiens	65.49	3.00e-138	483.00
IUUC-Hvu-047141	Hordeum vulgare	60.00	4.00e-15	74.70
IUUC-Itr-048731	Ictidomys tridecemlineatus	67.26	2.00e-138	484.00
IUUC-Lch-049638	Latimeria chalumnae	65.46	6.00e-134	469.00
IUUC-Lpe-051132	Leersia perrieri	30.96	1.00e-17	82.80
IUUC-Loc-052427	Lepisosteus oculatus	72.60	5.00e-147	512.00
IUUC-Laf-053758	Loxodonta africana	69.69	3.00e-143	499.00
IUUC-Mcc-054755	Macaca mulatta	75.20	8.00e-138	482.00
IUUC-Meu-056004	Macropus eugenii	71.83	1.00e-92	332.00
IUUC-Mtr-058392	Medicago truncatula	34.53	4.00e-30	124.00
IUUC-Mga-059466	Meleagris gallopavo	72.19	7.00e-132	462.00
IUUC-Mmr-060890	Microcebus murinus	64.84	2.00e-137	481.00
IUUC-Mdo-062197	Monodelphis domestica	77.89	5.00e-141	492.00
IUUC-Mmu-063823	Mus musculus	74.14	2.00e-137	481.00
IUUC-Mac-064858	Musa acuminata	39.66	2.00e-20	91.30
IUUC-Mpu-066181	Mustela putorius furo	66.37	5.00e-138	482.00
IUUC-Mlu-067079	Myotis lucifugus	70.45	9.00e-135	471.00
IUUC-Nle-070180	Nomascus leucogenys	64.73	5.00e-128	449.00
IUUC-Opr-070344	Ochotona princeps	76.82	2.00e-139	487.00
IUUC-Ont-071846	Oreochromis niloticus	71.18	8.00e-126	442.00
IUUC-Oan-073378	Ornithorhynchus anatinus	67.09	2.00e-125	440.00
IUUC-Ocu-074652	Oryctolagus cuniculus	75.46	1.00e-136	478.00
IUUC-Oba-075256	Oryza barthii	62.50	2.00e-15	75.10
IUUC-Obr-076302	Oryza brachyantha	30.61	5.00e-16	77.80
IUUC-Ogl-077097	Oryza glaberrima	29.57	3.00e-17	81.30
IUUC-Ogu-078570	Oryza glumaepatula	29.57	3.00e-17	81.30
IUUC-Oin-079244	Oryza indica	30.00	2.00e-17	82.00
IUUC-Olo-080484	Oryza longistaminata	62.50	1.00e-15	75.50
IUUC-Ome-081814	Oryza meridionalis	30.17	8.00e-17	80.10
IUUC-Oni-082057	Oryza nivara	30.00	2.00e-17	82.00
IUUC-Opu-084176	Oryza punctata	30.90	5.00e-17	80.50
IUUC-Oru-084618	Oryza rufipogon	30.00	2.00e-17	81.60
IUUC-Osa-085602	Oryza sativa	30.00	2.00e-17	81.60
IUUC-Ola-086707	Oryzias latipes	82.51	1.00e-96	344.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.39	5.00e-45	173.00
IUUC-Oga-088560	Otolemur garnettii	74.93	2.00e-135	473.00
IUUC-Oar-089200	Ovis aries	74.93	1.00e-137	481.00
IUUC-Ptr-090569	Pan troglodytes	65.49	2.00e-138	484.00
IUUC-Pan-091742	Papio anubis	75.20	6.00e-138	482.00
IUUC-Psi-093505	Pelodiscus sinensis	71.65	5.00e-131	459.00
IUUC-Ppa-095431	Physcomitrella patens	31.94	2.00e-25	108.00
IUUC-Pfo-097396	Poecilia formosa	69.75	4.00e-132	463.00
IUUC-Pab-098531	Pongo abelii	66.37	2.00e-138	483.00
IUUC-Pop-099661	Populus trichocarpa	32.90	3.00e-36	144.00
IUUC-Pca-101029	Procavia capensis	69.64	1.00e-118	418.00
IUUC-Ppe-101495	Prunus persica	29.04	9.00e-24	103.00
IUUC-Pva-102934	Pteropus vampyrus	65.05	1.00e-134	471.00
IUUC-Rno-106052	Rattus norvegicus	75.46	2.00e-141	493.00
IUUC-Sha-106876	Sarcophilus harrisii	76.30	6.00e-140	489.00
IUUC-Smo-109325	Selaginella moellendorffii	35.39	6.00e-35	139.00
IUUC-Sit-110624	Setaria italica	60.00	8.00e-15	73.60
IUUC-Sly-110865	Solanum lycopersicum	56.90	6.00e-08	47.80
IUUC-Stu-112433	Solanum tuberosum	34.06	7.00e-32	129.00
IUUC-Sar-113169	Sorex araneus	65.45	1.00e-99	355.00
IUUC-Sbi-114305	Sorghum bicolor	60.00	9.00e-15	73.60
IUUC-Ssc-115380	Sus scrofa	65.49	1.00e-141	494.00
IUUC-Tgu-117280	Taeniopygia guttata	70.23	8.00e-136	475.00
IUUC-Tru-117732	Takifugu rubripes	69.17	3.00e-127	447.00
IUUC-Tsy-119624	Tarsius syrichta	61.66	5.00e-123	432.00
IUUC-Tni-119852	Tetraodon nigroviridis	64.66	3.00e-118	417.00
IUUC-Tca-121865	Theobroma cacao	34.71	2.00e-21	95.10
IUUC-Tae-125925	Triticum aestivum	60.00	4.00e-15	74.30
IUUC-Tur-126237	Triticum urartu	60.00	4.00e-15	73.90
IUUC-Tbe-127632	Tupaia belangeri	81.40	3.00e-114	403.00
IUUC-Ttr-129008	Tursiops truncatus	64.84	2.00e-135	474.00
IUUC-Vpa-130625	Vicugna pacos	57.83	2.00e-97	347.00
IUUC-Vvi-131312	Vitis vinifera	35.88	1.00e-20	92.80
IUUC-Xtr-132756	Xenopus tropicalis	69.43	3.00e-146	509.00
IUUC-Xma-133377	Xiphophorus maculatus	70.08	3.00e-128	450.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence