iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049903

Ensembl Protein ID

ENSLACP00000007910.2

UniProt Accession

H3AE39; H3AE39_LATCH

Genbank Protein ID

ENSLACP00000007910

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01009516

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000007000.2	ENSLACT00000007976.2	ENSLACP00000007910.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.30e-13	48.9	3412	3443
E3 activity/HECT	1.70e-91	307.4	4501	4835

Active Site

Position(s)	Description	Evidence
4804	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H+++vt++ + s  +ll++ ++Dgt++vW+++
   Q: 3412 HQNKVTACGWcSKkGLLATTGNDGTVRVWNVT 3443
           99********9778****************97 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     eh+  F+flG+l+g+a+++++
   Q: 4501 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLFNPsacidEHIMQFKFLGILMGVAIRTKK 4587
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +lsledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4588 PLDLHLAPMVWKQLCCIPLSLEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGSSIPLTFSNRK 4674
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG++++ip  l+sl+t+++le+++cG++ei+v+ lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4675 EYVERAIEYRLHE-MDRQVAAVREGMSWIIPVPLMSLLTAKQLEQMVCGMAEISVDVLKKVVRYRE-VDEQHQLVQWFWQTLEEFSN 4759
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Ys++  + e+L+yAi++++++++
   Q: 4760 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSNQPLMAERLRYAINNCRSIDM 4835
           *****************6.899999.679999956666***********************************99987 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MAVMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAILYTK LVNNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQEHYLD ALLNSQLALA KMVCSDSPFA AALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTTGTTGT CAATAAACAC AGTTGACGTC AGACTGACGT GCCGCCGCCC CGCTCTGTTT 60
GTAGGGGGGG GGGGGAGACG AAATGGCTAG TCTGATGTTT CCCTGTTACA GGGAGACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	87.16	0.00e+00	7868.00
IUUC-Atr-003065	Amborella trichopoda	34.97	1.00e-49	191.00
IUUC-Apl-003461	Anas platyrhynchos	87.98	0.00e+00	7949.00
IUUC-Aca-004452	Anolis carolinensis	82.16	0.00e+00	7151.00
IUUC-Aly-006545	Arabidopsis lyrata	36.95	1.00e-49	191.00
IUUC-Ame-011268	Astyanax mexicanus	61.04	0.00e+00	2241.00
IUUC-Bta-013213	Bos taurus	87.50	0.00e+00	7854.00
IUUC-Bdi-014791	Brachypodium distachyon	35.57	6.00e-53	201.00
IUUC-Bol-015203	Brassica oleracea	35.65	2.00e-51	197.00
IUUC-Bra-017584	Brassica rapa	34.62	1.00e-49	191.00
IUUC-Cja-019298	Callithrix jacchus	87.11	0.00e+00	7868.00
IUUC-Cfa-021213	Canis familiaris	87.12	0.00e+00	7934.00
IUUC-Cpo-021674	Cavia porcellus	86.11	0.00e+00	5312.00
IUUC-Csa-023341	Chlorocebus sabaeus	87.19	0.00e+00	7865.00
IUUC-Cho-024567	Choloepus hoffmanni	85.31	0.00e+00	1576.00
IUUC-Dre-028289	Danio rerio	80.28	0.00e+00	7214.00
IUUC-Dno-029988	Dasypus novemcinctus	86.69	0.00e+00	7822.00
IUUC-Dor-030636	Dipodomys ordii	87.40	0.00e+00	2010.00
IUUC-Ete-032598	Echinops telfairi	81.61	0.00e+00	1336.00
IUUC-Eca-033754	Equus caballus	87.29	0.00e+00	7866.00
IUUC-Eeu-034702	Erinaceus europaeus	82.57	0.00e+00	1326.00
IUUC-Fca-035900	Felis catus	87.36	0.00e+00	7898.00
IUUC-Fal-037034	Ficedula albicollis	86.08	0.00e+00	6822.00
IUUC-Gmo-039260	Gadus morhua	77.03	0.00e+00	1280.00
IUUC-Gga-040321	Gallus gallus	87.96	0.00e+00	7992.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.41	0.00e+00	2231.00
IUUC-Gma-043808	Glycine max	34.73	4.00e-48	186.00
IUUC-Ggo-045134	Gorilla gorilla	81.88	0.00e+00	4174.00
IUUC-Hsa-046516	Homo sapiens	87.17	0.00e+00	7856.00
IUUC-Hvu-047529	Hordeum vulgare	34.29	9.00e-51	195.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	89.75	0.00e+00	2390.00
IUUC-Loc-052149	Lepisosteus oculatus	86.57	0.00e+00	7730.00
IUUC-Laf-053426	Loxodonta africana	87.17	0.00e+00	7911.00
IUUC-Mcc-055826	Macaca mulatta	87.19	0.00e+00	7881.00
IUUC-Meu-056521	Macropus eugenii	81.19	0.00e+00	1907.00
IUUC-Mtr-058277	Medicago truncatula	34.95	2.00e-52	199.00
IUUC-Mga-059567	Meleagris gallopavo	92.78	0.00e+00	2027.00
IUUC-Mmr-061512	Microcebus murinus	86.70	0.00e+00	7773.00
IUUC-Mdo-062177	Monodelphis domestica	85.55	0.00e+00	7702.00
IUUC-Mmu-064373	Mus musculus	87.21	0.00e+00	7849.00
IUUC-Mpu-066148	Mustela putorius furo	87.13	0.00e+00	7891.00
IUUC-Mlu-067680	Myotis lucifugus	86.90	0.00e+00	7804.00
IUUC-Nle-069633	Nomascus leucogenys	87.01	0.00e+00	7806.00
IUUC-Opr-070609	Ochotona princeps	80.08	0.00e+00	1224.00
IUUC-Ont-071249	Oreochromis niloticus	82.51	0.00e+00	7512.00
IUUC-Oan-073157	Ornithorhynchus anatinus	87.47	0.00e+00	7825.00
IUUC-Ocu-074841	Oryctolagus cuniculus	87.27	0.00e+00	7928.00
IUUC-Obr-076115	Oryza brachyantha	36.13	3.00e-48	186.00
IUUC-Olo-080768	Oryza longistaminata	35.65	7.00e-54	204.00
IUUC-Ola-086889	Oryzias latipes	81.04	0.00e+00	7341.00
IUUC-Oga-088459	Otolemur garnettii	86.21	0.00e+00	7773.00
IUUC-Oar-089888	Ovis aries	87.39	0.00e+00	7828.00
IUUC-Ptr-091114	Pan troglodytes	87.11	0.00e+00	7873.00
IUUC-Pan-092442	Papio anubis	87.07	0.00e+00	7858.00
IUUC-Psi-093833	Pelodiscus sinensis	87.65	0.00e+00	5195.00
IUUC-Pma-094275	Petromyzon marinus	78.63	0.00e+00	1738.00
IUUC-Ppa-095790	Physcomitrella patens	35.80	3.00e-55	209.00
IUUC-Pfo-097262	Poecilia formosa	81.27	0.00e+00	7205.00
IUUC-Pab-097760	Pongo abelii	86.82	0.00e+00	4452.00
IUUC-Pop-099121	Populus trichocarpa	35.60	3.00e-53	203.00
IUUC-Pca-100465	Procavia capensis	86.56	0.00e+00	4120.00
IUUC-Ppe-101345	Prunus persica	34.78	2.00e-53	204.00
IUUC-Pva-102950	Pteropus vampyrus	86.74	0.00e+00	3729.00
IUUC-Rno-104892	Rattus norvegicus	87.09	0.00e+00	7779.00
IUUC-Sha-106633	Sarcophilus harrisii	86.70	0.00e+00	7712.00
IUUC-Smo-108827	Selaginella moellendorffii	35.48	6.00e-53	202.00
IUUC-Sit-110415	Setaria italica	37.32	6.00e-54	204.00
IUUC-Sly-111155	Solanum lycopersicum	37.68	1.00e-55	211.00
IUUC-Stu-112166	Solanum tuberosum	32.74	3.00e-50	193.00
IUUC-Sar-113251	Sorex araneus	79.73	0.00e+00	2254.00
IUUC-Ssc-116391	Sus scrofa	87.33	0.00e+00	7886.00
IUUC-Tgu-116554	Taeniopygia guttata	87.27	0.00e+00	7913.00
IUUC-Tru-118695	Takifugu rubripes	82.12	0.00e+00	7470.00
IUUC-Tsy-119647	Tarsius syrichta	79.05	0.00e+00	4866.00
IUUC-Tni-120707	Tetraodon nigroviridis	81.82	0.00e+00	7411.00
IUUC-Tca-121094	Theobroma cacao	35.07	2.00e-51	197.00
IUUC-Tae-124157	Triticum aestivum	32.55	9.00e-46	179.00
IUUC-Tur-126300	Triticum urartu	34.29	3.00e-51	197.00
IUUC-Tbe-127346	Tupaia belangeri	80.33	0.00e+00	2341.00
IUUC-Ttr-128542	Tursiops truncatus	81.88	0.00e+00	5151.00
IUUC-Vpa-130611	Vicugna pacos	87.37	0.00e+00	3608.00
IUUC-Xtr-131933	Xenopus tropicalis	83.73	0.00e+00	7495.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence