iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17532487
E3 activity/N-recognin/UBR-box	UBR	17532487

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.20e-05	21.5	1311	1361
E3 activity/N-recognin/UBR-box	2.60e-25	87.2	97	171

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 9    kdgplvlpCgHvfhadCl..qkw..............pglknssskefrCPlCr 46
           +++p++  CgH  h++Cl  + +              p+++   s+ ++CP+C+
   Q: 1311 SCEPVLRACGHGSHTKCLsgH-MksirgiqnqttkniPLSY--GSGLIYCPVCN 1361
           33588888*********9742.3466888888888778888..999999****7 PP

E3 activity/N-recognin/UBR-box

   S: 2    lCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHey..klkksggggfCdCGdteAwedgs...kCkkll 71
           +C+r+++++etiy+C+tCs+++ +++C+ Cf+k++H++H+y  k++++++g++C+CGd++A++d+s   kCk++l
   Q: 97   ACTRLCFPSETIYYCFTCSTNPLYEICELCFDKEKHVNHSYvaKVVMRPEGRICHCGDPFAFNDPSdafKCKNEL 171
           8****************************************99**********************99999*9986 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E3 ubiquitin-protein ligase which probably functions outside the N-end rule pathway, since it lacks the residues essential for the degradation of N-end rule substrates. Mediates RPN4 ubiquitination and subsequent degradation.

Protein Sequence
(Fasta)

MEDSDLSITN IRDFLTELPK LAKCEYSETT SYLLWKTLNL RLKHSDNDIN WRSLVSILNS 60
EAWENEKYRD ILNGRKWRTL EFENDHHSVG NMHIGTACTR LCFPSETIYY CFTCSTNPLY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGATT CTGACCTGTC TATAACCAAT ATAAGAGATT TTCTTACCGA GCTCCCCAAA 60
CTCGCGAAAT GCGAATATAG CGAAACCACT AGTTATTTAC TATGGAAAAC CTTAAATCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990304--C:MUB1-RAD6-UBR2 ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

sce:YLR024C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	23.31	2.00e-11	63.90
IUUC-Aml-001876	Ailuropoda melanoleuca	24.30	6.00e-15	75.50
IUUC-Ago-007752	Ashbya gossypii	40.06	0.00e+00	1296.00
IUUC-Bdi-014635	Brachypodium distachyon	22.43	1.00e-12	67.80
IUUC-Csv-026033	Ciona savignyi	31.08	2.00e-07	45.80
IUUC-Cne-026823	Cryptococcus neoformans	30.13	1.00e-10	60.80
IUUC-Eeu-034783	Erinaceus europaeus	30.99	2.00e-09	56.60
IUUC-Gmo-039363	Gadus morhua	21.12	2.00e-13	70.50
IUUC-Gma-043622	Glycine max	23.15	5.00e-11	62.40
IUUC-Hvu-047707	Hordeum vulgare	22.26	5.00e-11	62.00
IUUC-Mtr-058538	Medicago truncatula	23.71	3.00e-11	63.50
IUUC-Mla-058963	Melampsora laricipopulina	21.91	9.00e-30	124.00
IUUC-Mac-064773	Musa acuminata	34.40	1.00e-10	61.60
IUUC-Oba-075295	Oryza barthii	34.29	3.00e-08	53.10
IUUC-Obr-076117	Oryza brachyantha	23.46	5.00e-14	72.80
IUUC-Ogl-077571	Oryza glaberrima	33.68	5.00e-11	62.80
IUUC-Ogu-078497	Oryza glumaepatula	34.29	3.00e-08	53.10
IUUC-Oin-079343	Oryza indica	34.29	3.00e-08	53.10
IUUC-Olo-081056	Oryza longistaminata	34.29	3.00e-08	53.50
IUUC-Oni-083099	Oryza nivara	34.29	3.00e-08	53.10
IUUC-Opu-083202	Oryza punctata	23.08	5.00e-13	69.30
IUUC-Oru-084471	Oryza rufipogon	34.29	3.00e-08	53.10
IUUC-Osa-085336	Oryza sativa	33.68	2.00e-11	62.80
IUUC-Pma-094152	Petromyzon marinus	27.84	1.00e-08	53.10
IUUC-Ppa-095715	Physcomitrella patens	28.31	2.00e-12	67.80
IUUC-Pop-099496	Populus trichocarpa	28.42	1.00e-09	57.80
IUUC-Pca-101009	Procavia capensis	22.93	2.00e-10	60.10
IUUC-Ppe-101802	Prunus persica	22.16	2.00e-10	60.50
IUUC-Pva-102538	Pteropus vampyrus	24.74	1.00e-13	70.90
IUUC-Pgr-103372	Puccinia graminis	22.54	2.00e-29	124.00
IUUC-Ptt-103878	Puccinia triticina	25.35	1.00e-31	130.00
IUUC-Ssl-108501	Sclerotinia sclerotiorum	34.88	1.40e-01	30.00
IUUC-Smo-108719	Selaginella moellendorffii	23.29	1.00e-14	74.30
IUUC-Sit-110716	Setaria italica	24.06	4.00e-13	69.70
IUUC-Sar-113332	Sorex araneus	24.17	4.00e-17	82.40
IUUC-Sbi-114577	Sorghum bicolor	22.43	3.00e-13	70.10
IUUC-Sre-115045	Sporisorium reilianum	22.45	6.00e-25	108.00
IUUC-Tae-125358	Triticum aestivum	23.31	3.00e-11	63.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence