iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116849

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01055525

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000003489.1	ENSTGUT00000003693.1	ENSTGUP00000003653.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.60e-100	334.4	732	1055

Active Site

Position(s)	Description	Evidence
1024	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 732  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTF-----EDSDLFHLIGVVCGLAIYNFTIVDL 813
           78999***********************************************98877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           p++ ++yk+ll+kk sl+dl+e+ p++ + +++++++ e+diee+ ++l+f+++ e++g+t+ +eL+p+G++ipV ++N++++v+++
   Q: 814  PFPLALYKKLLNKKPSLDDLKELIPDVGRGMQQLLDYPEDDIEEA-FCLNFTITVENFGTTEIKELVPKGADIPVVKQNRQDFVDAY 899
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ + af+eGf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +d+p+i+ Fwev++e+s e++k+f
   Q: 900  VDYIFNRSVASLYSAFHEGFHKVCGGKVLQLFQPSELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELSLEKKKQF 986
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G++ lk    vi+   + +d lP ++TCfn+L+LP+Y+ ke+lk+kL+ Ai++ +gF+l
   Q: 987  LLFLTGSDRIPILGMKCLK---LVIQPtGGGEDYLPVAHTCFNLLDLPKYTDKETLKSKLIQAIDHYEGFSL 1055
           *******************...6666658899**************************************97 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FLNKRVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK ARKRPEHVGA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL ATDGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGTGCT GGGGCAACGC ATCTTTTGGA CAGCTTGGAT TGGGTGGAAT TGATGAAGAG 60
ATTGTTTTAG AACCCAGAAA AAGTGACTTT TTCCTAAATA AAAGGGTCAG AGATGTAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	83.25	0.00e+00	1707.00
IUUC-Apl-003295	Anas platyrhynchos	90.64	0.00e+00	1916.00
IUUC-Aca-004336	Anolis carolinensis	81.79	0.00e+00	1743.00
IUUC-Ame-010768	Astyanax mexicanus	69.97	0.00e+00	1492.00
IUUC-Bta-013279	Bos taurus	83.44	0.00e+00	1709.00
IUUC-Cja-019023	Callithrix jacchus	83.07	0.00e+00	1695.00
IUUC-Cfa-021074	Canis familiaris	83.25	0.00e+00	1708.00
IUUC-Cpo-021461	Cavia porcellus	81.68	0.00e+00	1672.00
IUUC-Csa-024261	Chlorocebus sabaeus	83.63	0.00e+00	1709.00
IUUC-Cho-024513	Choloepus hoffmanni	68.21	0.00e+00	1333.00
IUUC-Cin-025232	Ciona intestinalis	41.82	0.00e+00	784.00
IUUC-Dre-028829	Danio rerio	70.19	0.00e+00	1436.00
IUUC-Dno-029445	Dasypus novemcinctus	79.71	0.00e+00	1350.00
IUUC-Dor-030158	Dipodomys ordii	78.05	0.00e+00	697.00
IUUC-Dme-032103	Drosophila melanogaster	44.66	0.00e+00	852.00
IUUC-Ete-033072	Echinops telfairi	71.30	0.00e+00	1436.00
IUUC-Eca-033317	Equus caballus	82.31	0.00e+00	1683.00
IUUC-Fca-035682	Felis catus	82.69	0.00e+00	1687.00
IUUC-Fal-036969	Ficedula albicollis	93.28	0.00e+00	1971.00
IUUC-Gmo-038671	Gadus morhua	68.88	0.00e+00	1462.00
IUUC-Gga-041174	Gallus gallus	90.54	0.00e+00	1912.00
IUUC-Gac-042600	Gasterosteus aculeatus	69.21	0.00e+00	1418.00
IUUC-Ggo-044589	Gorilla gorilla	83.25	0.00e+00	1722.00
IUUC-Hsa-046772	Homo sapiens	83.25	0.00e+00	1721.00
IUUC-Lch-050147	Latimeria chalumnae	76.42	0.00e+00	1335.00
IUUC-Loc-052684	Lepisosteus oculatus	75.21	0.00e+00	1574.00
IUUC-Laf-053844	Loxodonta africana	82.69	0.00e+00	1697.00
IUUC-Mcc-055531	Macaca mulatta	81.68	0.00e+00	1693.00
IUUC-Mga-060151	Meleagris gallopavo	89.46	0.00e+00	1581.00
IUUC-Mmr-060954	Microcebus murinus	83.54	0.00e+00	1708.00
IUUC-Mdo-062246	Monodelphis domestica	80.35	0.00e+00	1538.00
IUUC-Mmu-063369	Mus musculus	81.74	0.00e+00	1708.00
IUUC-Mpu-065936	Mustela putorius furo	82.69	0.00e+00	1560.00
IUUC-Mlu-067326	Myotis lucifugus	82.69	0.00e+00	1668.00
IUUC-Nle-069453	Nomascus leucogenys	82.59	0.00e+00	1680.00
IUUC-Ont-071720	Oreochromis niloticus	70.10	0.00e+00	1442.00
IUUC-Oan-073464	Ornithorhynchus anatinus	82.08	0.00e+00	1569.00
IUUC-Ocu-074207	Oryctolagus cuniculus	80.34	0.00e+00	1540.00
IUUC-Ola-086762	Oryzias latipes	69.03	0.00e+00	1390.00
IUUC-Oga-088435	Otolemur garnettii	83.35	0.00e+00	1704.00
IUUC-Oar-089233	Ovis aries	83.54	0.00e+00	1711.00
IUUC-Ptr-091368	Pan troglodytes	83.44	0.00e+00	1725.00
IUUC-Pan-092300	Papio anubis	83.63	0.00e+00	1709.00
IUUC-Psi-093406	Pelodiscus sinensis	86.38	0.00e+00	1847.00
IUUC-Pma-094113	Petromyzon marinus	66.51	0.00e+00	1049.00
IUUC-Pfo-097021	Poecilia formosa	68.43	0.00e+00	1479.00
IUUC-Pab-098327	Pongo abelii	83.35	0.00e+00	1721.00
IUUC-Pca-101075	Procavia capensis	72.26	2.00e-176	612.00
IUUC-Pva-102909	Pteropus vampyrus	73.42	0.00e+00	1424.00
IUUC-Rno-105457	Rattus norvegicus	82.50	0.00e+00	1729.00
IUUC-Sha-106632	Sarcophilus harrisii	81.93	0.00e+00	1707.00
IUUC-Sar-113679	Sorex araneus	71.21	0.00e+00	894.00
IUUC-Tru-118206	Takifugu rubripes	68.48	0.00e+00	1372.00
IUUC-Tsy-119521	Tarsius syrichta	72.28	0.00e+00	1392.00
IUUC-Tni-120233	Tetraodon nigroviridis	68.24	0.00e+00	1367.00
IUUC-Tbe-127941	Tupaia belangeri	69.69	0.00e+00	1171.00
IUUC-Vpa-130448	Vicugna pacos	83.25	0.00e+00	1704.00
IUUC-Xtr-132719	Xenopus tropicalis	66.29	0.00e+00	1275.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence